CHEMBL3267 IC50
BioactivityChEMBL CHEMBL3267 IC50 bioactivity data
1733 compounds · Target: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform ( CHEMBL3267 ↗ ) · UniProt: P48736 ↗ · IC50
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
1821 ↗ |
O=c1cc(N2CCOCC2)oc2c(-c3cccc4c3sc3ccccc34)cccc12
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
220.00 | IC50 | CHEMBL188678 | ChEMBL ↗ |
|
2382 ↗ |
CCC(=O)N1CCN(S(=O)(=O)c2cccc(Nc3ncc4c(n3)N(C)c3ccc(C)cc3C(=O)N4C)c2)CC1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
11.00 | IC50 | CHEMBL3942643 | ChEMBL ↗ |
|
2384 ↗ |
Cc1ccc2c(c1)C(=O)N(C)c1cnc(Nc3cccc(S(=O)(=O)N4CCC(O)CC4)c3)nc1N2C
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
6.50 | IC50 | CHEMBL3959351 | ChEMBL ↗ |
|
2394 ↗ |
C=CC(=O)N1CCN(S(=O)(=O)c2cccc(Nc3ncc4c(n3)N(C)c3ccc(C)cc3C(=O)N4C)c2)CC1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
2.80 | IC50 | CHEMBL3979343 | ChEMBL ↗ |
|
7350 ↗ |
CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(NCc3ccc(C(=O)NO)cn3)c2c(=O)n1-c1ccccc1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
135.00 | IC50 | CHEMBL4443548 | ChEMBL ↗ |
|
7361 ↗ |
CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(CCCCCC(=O)NO)c2c(=O)n1-c1ccccc1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
43.00 | IC50 | CHEMBL4451623 | ChEMBL ↗ |
|
7380 ↗ |
CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(NCc3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
103.00 | IC50 | CHEMBL4516095 | ChEMBL ↗ |
|
8674 ↗ |
COc1ccc(-c2nc(N3CCOCC3)c3nc(CN(C)c4ncc(C(=O)NO)cn4)n(C)c3n2)cn1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
255.00 | IC50 | CHEMBL3827281 | ChEMBL ↗ |
|
8677 ↗ |
CN(Cc1nc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc2n1C)c1ncc(C(=O)NO)cn1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
8.10 | IC50 | CHEMBL3827894 | ChEMBL ↗ |
|
8698 ↗ |
O=C(CCCCCCOc1ccc2cc1COC/C=C/COCc1cccc(c1)-c1ccnc(n1)N2)NO
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
10.00 | IC50 | CHEMBL3917405 | ChEMBL ↗ |
|
9110 ↗ |
CC[C@H](Nc1nc(N)nc(C(F)F)c1C#N)c1nc2cccc(NCc3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
222.00 | IC50 | CHEMBL4435002 | ChEMBL ↗ |
|
9147 ↗ |
CC[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(CCCCCC(=O)NO)c2c(=O)n1-c1ccccc1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
2.00 | IC50 | CHEMBL4443378 | ChEMBL ↗ |
|
9171 ↗ |
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CCc3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
2.00 | IC50 | CHEMBL4450613 | ChEMBL ↗ |
|
9183 ↗ |
CC[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(NCc3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
9.00 | IC50 | CHEMBL4455923 | ChEMBL ↗ |
|
9200 ↗ |
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(NCc3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
4.00 | IC50 | CHEMBL4460447 | ChEMBL ↗ |
|
9210 ↗ |
COc1ccc(-c2cc(OCCN(C)c3ncc(C(=O)NO)cn3)c3ncnc(C)c3c2)cn1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
467.00 | IC50 | CHEMBL4462577 | ChEMBL ↗ |
|
9213 ↗ |
CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(CNC(=O)c3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
234.00 | IC50 | CHEMBL4464003 | ChEMBL ↗ |
|
9215 ↗ |
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(NCc3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
45.00 | IC50 | CHEMBL4464812 | ChEMBL ↗ |
|
9275 ↗ |
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CNC(=O)c3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
10.00 | IC50 | CHEMBL4522666 | ChEMBL ↗ |
|
9278 ↗ |
CC[C@H](Nc1nc(N)ncc1C)c1nc2cccc(CCCCCC(=O)NO)c2c(=O)n1-c1ccccc1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
1.77×103 | IC50 | CHEMBL4525968 | ChEMBL ↗ |
|
9282 ↗ |
Cc1nc(N)nc(N[C@@H](C)c2nc3cccc(NCc4ccc(C(=O)NO)cc4)c3c(=O)n2-c2ccccc2)c1C#N
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
2.00 | IC50 | CHEMBL4526673 | ChEMBL ↗ |
|
9302 ↗ |
COc1ncc(-c2cc(OCCCCCCC(=O)NO)c3ncnc(C)c3c2)cc1F
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
67.00 | IC50 | CHEMBL4536105 | ChEMBL ↗ |
|
9314 ↗ |
CC[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(NCCCCC(=O)NO)c2c(=O)n1-c1ccccc1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
8.00 | IC50 | CHEMBL4544187 | ChEMBL ↗ |
|
9330 ↗ |
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CCCCCC(=O)NO)c2c(=O)n1-c1ccccc1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
3.00 | IC50 | CHEMBL4550648 | ChEMBL ↗ |
|
9381 ↗ |
CC[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(NCc3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
752.00 | IC50 | CHEMBL4578757 | ChEMBL ↗ |
|
9389 ↗ |
CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(CNc3ncc(C(=O)NO)cn3)c2c(=O)n1-c1ccccc1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
995.00 | IC50 | CHEMBL4581057 | ChEMBL ↗ |
|
9393 ↗ |
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CNc3ncc(C(=O)NO)cn3)c2c(=O)n1-c1ccccc1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
15.00 | IC50 | CHEMBL4583074 | ChEMBL ↗ |
|
9399 ↗ |
CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(NCc3ccc(C(=O)NO)c(C)c3)c2c(=O)n1-c1ccccc1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
203.00 | IC50 | CHEMBL4586038 | ChEMBL ↗ |
|
9467 ↗ |
Nc1ncc(-c2nc(N3CCOCC3)c3ccn(CCCCCCC(=O)NO)c3n2)cn1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
92.00 | IC50 | CHEMBL4744689 | ChEMBL ↗ |
|
9481 ↗ |
O=C(CCCCCCn1cnc2c(N3CCOCC3)nc(-c3cccc(CO)c3)nc21)NO
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
177.00 | IC50 | CHEMBL4749655 | ChEMBL ↗ |
|
9562 ↗ |
Nc1ccc(-c2nc(N3CCOCC3)c3ncn(CCCCCCC(=O)NO)c3n2)cn1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
793.00 | IC50 | CHEMBL4785064 | ChEMBL ↗ |
|
10208 ↗ |
N#Cc1c(N)nc(N)nc1N1CC2(CC2)C[C@H]1c1nc2cccc(Cl)c2c(=O)n1Cc1ccc(C(=O)NO)s1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
30.50 | IC50 | CHEMBL5218472 | ChEMBL ↗ |
|
13340 ↗ |
O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
13.79×103 | IC50 | CHEMBL50 | ChEMBL ↗ |
|
16114 ↗ |
O=C1NC(=O)/C(=C/c2ccc3nccnc3c2)S1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
8.50 | IC50 | CHEMBL568150 | ChEMBL ↗ |
|
16199 ↗ |
Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
3.20×103 | IC50 | CHEMBL1614712 | ChEMBL ↗ |
|
17017 ↗ |
Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
980.00 | IC50 | CHEMBL3787112 | ChEMBL ↗ |
|
17679 ↗ |
O=c1c(O)c(-c2cc(O)c(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
4.72×103 | IC50 | CHEMBL164 | ChEMBL ↗ |
|
20784 ↗ |
Nc1ncnc2c1c(-c1cnc3[nH]ccc3c1)nn2C1CCCC1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
1.10×103 | IC50 | CHEMBL1081312 | ChEMBL ↗ |
|
20857 ↗ |
CC(C)n1nc(-c2cccc(O)c2)c2c(N)ncnc21
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
1.50×103 | IC50 | CHEMBL1230790 | ChEMBL ↗ |
|
20859 ↗ |
COc1ccc(-c2nn(C3CCC3)c3ncnc(N)c23)cc1OC
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
72.00 | IC50 | CHEMBL1233881 | ChEMBL ↗ |
|
20860 ↗ |
CC(C)n1nc(-c2ccc3ncccc3c2)c2c(N)ncnc21
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
43.00 | IC50 | CHEMBL1233882 | ChEMBL ↗ |
|
20861 ↗ |
Cn1nc(-c2ccc3ccccc3c2)c2c(N)ncnc21
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
570.00 | IC50 | CHEMBL1234815 | ChEMBL ↗ |
|
21519 ↗ |
COc1cc(Nc2nccc(-c3ccc(Cl)cc3)n2)cc(OC)c1OC
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
65.00 | IC50 | CHEMBL3134612 | ChEMBL ↗ |
|
22941 ↗ |
CCS(=O)(=O)Nc1cc(-c2ccc3ncnc(Nc4cccc(C(=O)OC)c4)c3c2)cnc1OC
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
1.78×103 | IC50 | CHEMBL4206585 | ChEMBL ↗ |
|
22943 ↗ |
CCS(=O)(=O)Nc1cc(-c2ccc3ncnc(Nc4ccc(F)c(Cl)c4)c3c2)cnc1OC
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
3.56×103 | IC50 | CHEMBL4207750 | ChEMBL ↗ |
|
36770 ↗ |
C[C@@H](Oc1cc(-n2cnc3ccc(OC4CCN(C)CC4)cc32)sc1C(N)=O)c1ccccc1C(F)(F)F
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
390.00 | IC50 | CHEMBL1615278 | ChEMBL ↗ |
|
37048 ↗ |
O=c1cc(N2CCOCC2)oc2c(-c3ccc4c(c3)OCCO4)csc12
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
1.31×103 | IC50 | CHEMBL2322228 | ChEMBL ↗ |
|
37250 ↗ |
O=C1NC(=S)S/C1=C\c1ccc2ncccc2c1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
2.30 | IC50 | CHEMBL3774448 | ChEMBL ↗ |
|
37507 ↗ |
O=C(Nc1cc(-c2ccc(O)cc2)cc2[nH]ncc12)c1ccccn1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
5.01×103 | IC50 | CHEMBL4161596 | ChEMBL ↗ |
|
37510 ↗ |
O=C(Nc1cc(-c2cccc3[nH]ccc23)cc2[nH]ncc12)c1ccccn1
|
CHEMBL3267 ↗
UniProt: P48736 ↗ |
6.31×103 | IC50 | CHEMBL4165288 | ChEMBL ↗ |