CHEMBL333 IC50
BioactivityChEMBL CHEMBL333 IC50 bioactivity data
1411 compounds · Target: 72 kDa type IV collagenase ( CHEMBL333 ↗ ) · UniProt: P08253 ↗ · IC50
72 kDa type IV collagenase, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
5618 ↗ |
O=C(NO)[C@H]1CC2(CC2)CN[C@@H]1C(=O)N1CCN(c2ccccc2)CC1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
200.00 | IC50 | CHEMBL221857 | ChEMBL ↗ |
|
5736 ↗ |
O=C(NO)[C@H]1CC2(CC2)CN[C@@H]1C(=O)N1CCC(c2ccccc2)C1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
998.00 | IC50 | CHEMBL252246 | ChEMBL ↗ |
|
5926 ↗ |
CN1CC2(CC2)C[C@H](C(=O)NO)[C@H]1C(=O)N1CCN(c2ccccc2)CC1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
150.00 | IC50 | CHEMBL387202 | ChEMBL ↗ |
|
6299 ↗ |
O=C(CC1CN[C@H](C(=O)N2CCC(c3ccccc3)C2)[C@@H](C(=O)NO)C1)NCCCCCNC(=O)OCc1ccccc1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
1.28×103 | IC50 | CHEMBL445717 | ChEMBL ↗ |
|
6394 ↗ |
O=C(NO)[C@H]1CC(CC(=O)N2CCCC2)CN[C@@H]1C(=O)N1CCN(c2ccccc2)CC1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
8.00 | IC50 | CHEMBL495596 | ChEMBL ↗ |
|
6395 ↗ |
NCCCCCNC(=O)CC1CN[C@H](C(=O)N2CCC(c3ccccc3)C2)[C@@H](C(=O)NO)C1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
1.66×103 | IC50 | CHEMBL495797 | ChEMBL ↗ |
|
6396 ↗ |
CN1CC(CC(=O)N2CCCC2)C[C@H](C(=O)NO)[C@H]1C(=O)N1CCN(c2ccccc2)CC1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
92.00 | IC50 | CHEMBL496018 | ChEMBL ↗ |
|
6398 ↗ |
CN1CC(CC(=O)N2CCCCC2)C[C@H](C(=O)NO)[C@H]1C(=O)N1CCN(c2ccccc2)CC1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
81.00 | IC50 | CHEMBL496211 | ChEMBL ↗ |
|
6399 ↗ |
O=C(NO)[C@H]1CCCC[C@@H]1C(=O)N1CCN(c2ccccc2)CC1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
180.00 | IC50 | CHEMBL496212 | ChEMBL ↗ |
|
6400 ↗ |
O=C(NO)[C@H]1C[C@@H](CC(=O)N2CCCCC2)CC[C@@H]1C(=O)N1CCN(c2ccccc2)CC1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
100.00 | IC50 | CHEMBL496628 | ChEMBL ↗ |
|
6401 ↗ |
O=C(NO)[C@H]1C[C@H](CC(=O)N2CCCCC2)CC[C@@H]1C(=O)N1CCN(c2ccccc2)CC1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
1.09×103 | IC50 | CHEMBL496629 | ChEMBL ↗ |
|
6402 ↗ |
O=C(NO)[C@H]1CC(CC(=O)N2CCOCC2)CC[C@@H]1C(=O)N1CCN(c2ccccc2)CC1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
236.00 | IC50 | CHEMBL496825 | ChEMBL ↗ |
|
6404 ↗ |
O=C(NO)[C@H]1CC(CC(=O)N2CCCCC2)CC[C@@H]1C(=O)N1CCN(c2ccccc2)CC1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
321.00 | IC50 | CHEMBL497026 | ChEMBL ↗ |
|
6405 ↗ |
O=C(NO)[C@H]1CC(CC(=O)N2CC[C@@H](O)C2)CC[C@@H]1C(=O)N1CCN(c2ccccc2)CC1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
156.00 | IC50 | CHEMBL497032 | ChEMBL ↗ |
|
6406 ↗ |
CN1CCN(C(=O)CC2CC[C@H](C(=O)N3CCN(c4ccccc4)CC3)[C@@H](C(=O)NO)C2)CC1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
68.00 | IC50 | CHEMBL497222 | ChEMBL ↗ |
|
6472 ↗ |
O=C(NO)[C@H]1CC2(CC[C@@H]1C(=O)N1CCN(c3ccccc3)CC1)CC2
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
106.00 | IC50 | CHEMBL521719 | ChEMBL ↗ |
|
6474 ↗ |
O=C(NO)[C@H]1CC(CC(=O)N2CCCC2)CC[C@@H]1C(=O)N1CCN(c2ccccc2)CC1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
271.00 | IC50 | CHEMBL523076 | ChEMBL ↗ |
|
12724 ↗ |
Oc1cc(O)cc(/C=C/c2ccc(O)cc2O)c1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
27.60×103 | IC50 | CHEMBL43065 | ChEMBL ↗ |
|
13340 ↗ |
O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
6.68×103 | IC50 | CHEMBL50 | ChEMBL ↗ |
|
14375 ↗ |
O=C(/C=C/c1ccccc1)Nc1ccccc1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
8.95 | IC50 | CHEMBL1830129 | ChEMBL ↗ |
|
14376 ↗ |
Cc1cccc(NC(=O)/C=C/c2ccccc2)c1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
1.95×103 | IC50 | CHEMBL1830130 | ChEMBL ↗ |
|
14377 ↗ |
O=C(/C=C/c1ccccc1)Nc1cccc(Cl)c1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
1.65×103 | IC50 | CHEMBL1830131 | ChEMBL ↗ |
|
14386 ↗ |
O=C(/C=C/c1ccc(O)cc1)Nc1cccc(Cl)c1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
1.73×103 | IC50 | CHEMBL1830143 | ChEMBL ↗ |
|
17678 ↗ |
O=c1cc(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
3.61×103 | IC50 | CHEMBL151 | ChEMBL ↗ |
|
19476 ↗ |
O=C(/C=C/c1ccc(O)cc1)c1ccc(O)cc1O
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
10.00 | IC50 | CHEMBL129795 | ChEMBL ↗ |
|
20908 ↗ |
O=C(O)/C=C/c1ccc(O)c(O)c1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
24.26 | IC50 | CHEMBL145 | ChEMBL ↗ |
|
20991 ↗ |
O=C(/C=C/c1ccccc1)Nc1ccccc1Cl
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
9.99 | IC50 | CHEMBL1981977 | ChEMBL ↗ |
|
20993 ↗ |
O=C(/C=C/c1ccccc1)Nc1ccccc1F
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
9.66 | IC50 | CHEMBL1998736 | ChEMBL ↗ |
|
21235 ↗ |
O=C(/C=C/c1ccccc1)Nc1ccc(Cl)cc1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
9.72 | IC50 | CHEMBL2336335 | ChEMBL ↗ |
|
21236 ↗ |
COc1ccccc1NC(=O)/C=C/c1ccccc1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
6.32 | IC50 | CHEMBL2336355 | ChEMBL ↗ |
|
21237 ↗ |
COc1ccc(NC(=O)/C=C/c2ccccc2)cc1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
5.37 | IC50 | CHEMBL2336357 | ChEMBL ↗ |
|
21238 ↗ |
Cc1ccccc1NC(=O)/C=C/c1ccccc1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
6.41 | IC50 | CHEMBL2336358 | ChEMBL ↗ |
|
21239 ↗ |
Cc1ccc(NC(=O)/C=C/c2ccccc2)cc1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
5.46 | IC50 | CHEMBL2336359 | ChEMBL ↗ |
|
21240 ↗ |
O=C(/C=C/c1ccccc1)Nc1ccc(F)cc1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
9.17 | IC50 | CHEMBL2336361 | ChEMBL ↗ |
|
24232 ↗ |
O=C(/C=C/c1cccc(O)c1)Nc1cccc(Cl)c1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
1.94×103 | IC50 | CHEMBL1830141 | ChEMBL ↗ |
|
27116 ↗ |
O=P(O)(O)CP(=O)(O)O
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
49.00×103 | IC50 | CHEMBL180570 | ChEMBL ↗ |
|
27614 ↗ |
O=C(CNOCc1ccccc1)NO
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
94.00×103 | IC50 | CHEMBL226149 | ChEMBL ↗ |
|
27616 ↗ |
COc1ccc(S(=O)(=O)N(CC(=O)NO)OCc2ccccc2)cc1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
1.06×103 | IC50 | CHEMBL226438 | ChEMBL ↗ |
|
27617 ↗ |
COc1ccc(S(=O)(=O)N(CC(=O)NO)OC(C)C)cc1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
4.25×103 | IC50 | CHEMBL226439 | ChEMBL ↗ |
|
27618 ↗ |
CCCCCCCCCCCCCCON(CC(=O)NO)S(=O)(=O)c1ccc(OC)cc1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
30.00×103 | IC50 | CHEMBL227565 | ChEMBL ↗ |
|
27619 ↗ |
O=C(CNOCc1ccc(Cl)cc1)NO
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
137.00×103 | IC50 | CHEMBL227566 | ChEMBL ↗ |
|
27620 ↗ |
COc1ccc(S(=O)(=O)N(CC(=O)NO)OC2C3CC4CC(C3)CC2C4)cc1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
1.98×103 | IC50 | CHEMBL227567 | ChEMBL ↗ |
|
27621 ↗ |
COc1ccc(S(=O)(=O)N(CC(=O)NO)OCc2ccc(OCc3ccccc3)cc2)cc1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
2.10×103 | IC50 | CHEMBL228176 | ChEMBL ↗ |
|
27622 ↗ |
CC(NOCc1ccc(Cl)cc1)C(=O)NO
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
68.00×103 | IC50 | CHEMBL228229 | ChEMBL ↗ |
|
27623 ↗ |
CCCCC(NOCc1ccccc1)C(=O)NO
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
33.85×103 | IC50 | CHEMBL228230 | ChEMBL ↗ |
|
27624 ↗ |
CCC(C)C(NOCc1ccccc1)C(=O)NO
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
151.00×103 | IC50 | CHEMBL228231 | ChEMBL ↗ |
|
27784 ↗ |
COc1ccc(S(=O)(=O)N(CC(=O)NO)CC(=O)NCCc2ccc(S(N)(=O)=O)cc2)cc1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
25.30 | IC50 | CHEMBL234529 | ChEMBL ↗ |
|
27785 ↗ |
NS(=O)(=O)c1ccc(CCNC(=O)CN(CC(=O)NO)S(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
1.57 | IC50 | CHEMBL234530 | ChEMBL ↗ |
|
27786 ↗ |
NS(=O)(=O)c1ccc(CCNC(=O)CN(CC(=O)NO)S(=O)(=O)c2ccc(-c3ccccc3)cc2)cc1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
16.20 | IC50 | CHEMBL234735 | ChEMBL ↗ |
|
28850 ↗ |
O=C(NO)[C@H]1C[C@H](NS(=O)(=O)c2ccc(-c3ccccc3)cc2)CN1S(=O)(=O)c1ccc(Cl)c(Cl)c1
|
CHEMBL333 ↗
UniProt: P08253 ↗ |
360.00 | IC50 | CHEMBL3633819 | ChEMBL ↗ |