CHEMBL3371 Ki
BioactivityChEMBL CHEMBL3371 Ki bioactivity data
2940 compounds · Target: 5-hydroxytryptamine receptor 6 ( CHEMBL3371 ↗ ) · UniProt: P50406 ↗ · Ki
5-hydroxytryptamine receptor 6, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
12122 ↗ |
O=S(=O)(c1ccccc1)n1ccc2c(OCCNCc3ccccc3)cccc21
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
2.60 | Ki | CHEMBL368698 | ChEMBL ↗ |
|
12287 ↗ |
O=S(=O)(c1ccccc1)n1ccc2c(N3CCN(CCCCCCNc4c5c(nc6ccccc46)CCCC5)CC3)cccc21
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
2.00 | Ki | CHEMBL3885186 | ChEMBL ↗ |
|
12876 ↗ |
CN(CCCN1CCN(c2cccc3c2ccn3Cc2ccccc2)CC1)Cc1ccccc1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
240.00 | Ki | CHEMBL4552323 | ChEMBL ↗ |
|
12928 ↗ |
Cc1c(OCc2ccccc2)cccc1N1CCN(CCCCCCNc2c3c(nc4c2CCCC4)CCCC3)CC1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
18.00 | Ki | CHEMBL4589118 | ChEMBL ↗ |
|
13237 ↗ |
CC(C)(C)OC(=O)N1CCCC(CNCCOc2cccc3c2CCN3S(=O)(=O)c2ccccc2)C1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
70.00 | Ki | CHEMBL4845699 | ChEMBL ↗ |
|
13241 ↗ |
CC(=O)Oc1ccc(CNCCOc2cccc3c2ccn3S(=O)(=O)c2ccccc2)cc1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
11.00 | Ki | CHEMBL4846931 | ChEMBL ↗ |
|
13248 ↗ |
Cc1cccc(CNCCOc2cccc3c2ccn3S(=O)(=O)c2ccccc2)c1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
15.00 | Ki | CHEMBL4849477 | ChEMBL ↗ |
|
13250 ↗ |
O=S(=O)(c1ccccc1)n1ccc2c(OCCNCc3cccc(Cl)c3)cccc21
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
5.00 | Ki | CHEMBL4849917 | ChEMBL ↗ |
|
13256 ↗ |
CC(C)(C)OC(=O)N1CCCC(CNCCOc2cccc3c2ccn3S(=O)(=O)c2ccccc2)C1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
26.00 | Ki | CHEMBL4852840 | ChEMBL ↗ |
|
13258 ↗ |
O=S(=O)(c1ccccc1)n1ccc2c(OCCNCC3CCCC3)cccc21
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
8.50 | Ki | CHEMBL4853545 | ChEMBL ↗ |
|
13260 ↗ |
O=S(=O)(c1ccccc1)n1ccc2c(OCCNCC3CCCCC3)cccc21
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
4.80 | Ki | CHEMBL4854460 | ChEMBL ↗ |
|
13273 ↗ |
CC(C)(C)OC(=O)N1CCCC(CNCCOc2cccc3c2ccn3Cc2ccccc2)C1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
369.00 | Ki | CHEMBL4859019 | ChEMBL ↗ |
|
13279 ↗ |
O=S(=O)(c1ccccc1)n1ccc2c(OCCNCc3ccccc3Cl)cccc21
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
30.00 | Ki | CHEMBL4863079 | ChEMBL ↗ |
|
13285 ↗ |
CC(C)(C)OC(=O)N1CCCC(CNCCOc2cccc3c2CCN3Cc2ccccc2)C1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
1.07×103 | Ki | CHEMBL4866550 | ChEMBL ↗ |
|
13292 ↗ |
CC(=O)Oc1cccc(CNCCOc2cccc3c2ccn3S(=O)(=O)c2ccccc2)c1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
6.50 | Ki | CHEMBL4867606 | ChEMBL ↗ |
|
13299 ↗ |
O=S(=O)(c1cccc2ccccc12)n1ccc2c(OCCNCc3ccccc3)cccc21
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
9.00 | Ki | CHEMBL4872486 | ChEMBL ↗ |
|
13725 ↗ |
C#CCN[C@@H]1CCc2ccccc21
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
1.40 | Ki | CHEMBL887 | ChEMBL ↗ |
|
14500 ↗ |
C/N=C1\NC(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
1.41×103 | Ki | CHEMBL2058415 | ChEMBL ↗ |
|
14503 ↗ |
C/N=C1\NC(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1C
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
2.31×103 | Ki | CHEMBL2058418 | ChEMBL ↗ |
|
14511 ↗ |
C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
7.52×103 | Ki | CHEMBL2058426 | ChEMBL ↗ |
|
14514 ↗ |
C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1C
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
7.30×103 | Ki | CHEMBL2058429 | ChEMBL ↗ |
|
14524 ↗ |
C/N=C1\NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
3.73×103 | Ki | CHEMBL2058703 | ChEMBL ↗ |
|
14525 ↗ |
C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
860.00 | Ki | CHEMBL2058704 | ChEMBL ↗ |
|
15838 ↗ |
C#CCN(C)Cc1ccc(OCCCCCN2CCN(c3cccc4c3ccn4S(=O)(=O)c3ccccc3)CC2)cc1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
38.00 | Ki | CHEMBL4741978 | ChEMBL ↗ |
|
15993 ↗ |
C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccccc23)N1C
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
1.72×103 | Ki | CHEMBL512332 | ChEMBL ↗ |
|
20110 ↗ |
CSc1nc2ccccn2c(=N)c1S(=O)(=O)c1ccccc1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
3.98 | Ki | CHEMBL355905 | ChEMBL ↗ |
|
24814 ↗ |
CN1C(=N)N(C)/C(=C/c2c[nH]c3ccccc23)C1=O
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
8.77×103 | Ki | CHEMBL404232 | ChEMBL ↗ |
|
24936 ↗ |
O=S(=O)(c1cccc(Cl)c1)n1ccc2c(N[C@H]3CCNC3)nc3ccccc3c21
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
3.00 | Ki | CHEMBL4125735 | ChEMBL ↗ |
|
25462 ↗ |
C#CCNC1CCc2c(OCCCCCN3CCN(c4cccc5c4ccn5Cc4cccc(Cl)c4)CC3)cccc21
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
223.00 | Ki | CHEMBL4754407 | ChEMBL ↗ |
|
25481 ↗ |
C#CCN(C)Cc1ccc(OCCCCCN2CCN(c3cccc4c3ccn4Cc3cccc(Cl)c3)CC2)cc1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
140.00 | Ki | CHEMBL4778708 | ChEMBL ↗ |
|
25485 ↗ |
C#CCNC1CCc2c(OCCCCCN3CCN(c4cccc5c4ccn5S(=O)(=O)c4ccccc4)CC3)cccc21
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
51.00 | Ki | CHEMBL4780498 | ChEMBL ↗ |
|
25504 ↗ |
C#CCN(C)Cc1ccc(OCCCCN2CCN(c3cccc4c3ccn4Cc3cccc(Cl)c3)CC2)cc1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
195.00 | Ki | CHEMBL4786924 | ChEMBL ↗ |
|
25522 ↗ |
C#CCNC1CCc2c(OCCCCN3CCN(c4cccc5c4ccn5Cc4cccc(Cl)c4)CC3)cccc21
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
113.00 | Ki | CHEMBL4794139 | ChEMBL ↗ |
|
25617 ↗ |
c1ccc(Cn2ccc3c(N4CCC5(COC5)C4)nc4ccccc4c32)cc1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
992.00 | Ki | CHEMBL5173511 | ChEMBL ↗ |
|
25618 ↗ |
COc1cccc(Cn2ccc3c(N4CCC(OC)CC4)nc4ccccc4c32)c1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
740.00 | Ki | CHEMBL5174789 | ChEMBL ↗ |
|
25619 ↗ |
Clc1cccc(Cn2ccc3c(N4CCC5(COC5)C4)nc4ccccc4c32)c1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
1.36×103 | Ki | CHEMBL5175763 | ChEMBL ↗ |
|
25621 ↗ |
COc1cccc(Cn2ccc3c(N4CCC(O)CC4)nc4ccccc4c32)c1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
1.34×103 | Ki | CHEMBL5177167 | ChEMBL ↗ |
|
25624 ↗ |
OC1CCN(c2nc3ccccc3c3c2ccn3Cc2cccc(Cl)c2)CC1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
1.71×103 | Ki | CHEMBL5178803 | ChEMBL ↗ |
|
25627 ↗ |
Clc1cccc(Cn2ccc3c(N4CC5(COC5)C4)nc4ccccc4c32)c1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
2.24×103 | Ki | CHEMBL5181534 | ChEMBL ↗ |
|
25632 ↗ |
O=S(=O)(c1cccc(Cl)c1)n1ccc2c(N[C@H]3CCOC3)nc3ccccc3c21
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
73.00 | Ki | CHEMBL5183690 | ChEMBL ↗ |
|
25634 ↗ |
Clc1cccc(Cn2ccc3c(NCC4CCOC4)nc4ccccc4c32)c1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
838.00 | Ki | CHEMBL5187034 | ChEMBL ↗ |
|
25636 ↗ |
CN(CCO)c1nc2ccccc2c2c1ccn2Cc1cccc(Cl)c1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
40.30×103 | Ki | CHEMBL5187539 | ChEMBL ↗ |
|
25638 ↗ |
COC1CCCN(c2nc3ccccc3c3c2ccn3Cc2cccc(Cl)c2)C1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
350.00 | Ki | CHEMBL5188859 | ChEMBL ↗ |
|
25648 ↗ |
Clc1cccc(Cn2ccc3c(N[C@H]4CCOC4)nc4ccccc4c32)c1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
1.74×103 | Ki | CHEMBL5193046 | ChEMBL ↗ |
|
25656 ↗ |
Clc1cccc(Cn2ccc3c(NCC4CCCO4)nc4ccccc4c32)c1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
696.00 | Ki | CHEMBL5197407 | ChEMBL ↗ |
|
25659 ↗ |
COc1cccc(Cn2ccc3c(NC4CCOCC4)nc4ccccc4c32)c1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
3.02×103 | Ki | CHEMBL5199814 | ChEMBL ↗ |
|
25660 ↗ |
FC1(F)CCN(c2nc3ccccc3c3c2ccn3Cc2cccc(Cl)c2)CC1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
3.83×103 | Ki | CHEMBL5200705 | ChEMBL ↗ |
|
25662 ↗ |
OC1CCCN(c2nc3ccccc3c3c2ccn3Cc2cccc(Cl)c2)C1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
1.23×103 | Ki | CHEMBL5201892 | ChEMBL ↗ |
|
25667 ↗ |
Clc1cccc(Cn2ccc3c(NC4CCOCC4)nc4ccccc4c32)c1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
33.06×103 | Ki | CHEMBL5206513 | ChEMBL ↗ |
|
25670 ↗ |
COC1CCN(c2nc3ccccc3c3c2ccn3Cc2cccc(Cl)c2)CC1
|
CHEMBL3371 ↗
UniProt: P50406 ↗ |
799.00 | Ki | CHEMBL5209131 | ChEMBL ↗ |