CHEMBL339 Ki
BioactivityChEMBL CHEMBL339 Ki bioactivity data
1040 compounds · Target: D(2) dopamine receptor ( CHEMBL339 ↗ ) · UniProt: P61169 ↗ · Ki
D(2) dopamine receptor, a molecular target studied in Rattus norvegicus.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
33643 ↗ |
COc1ccccc1N1CCN(CCNC(=O)c2ccncc2)CC1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
537.00 | Ki | CHEMBL104593 | ChEMBL ↗ |
|
33720 ↗ |
O=C1[C@@H]2[C@H]3CC[C@H](C3)[C@@H]2C(=O)N1C[C@@H]1CCCC[C@H]1CN1CCN(c2nsc3ccccc23)CC1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
1.68 | Ki | CHEMBL1237021 | ChEMBL ↗ |
|
33785 ↗ |
CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
220.00 | Ki | CHEMBL1258223 | ChEMBL ↗ |
|
33824 ↗ |
O[C@H]1[C@@H](NC[C@@H]2COc3ccccc3O2)CC[C@@H]1Oc1ccccc1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
1.12×103 | Ki | CHEMBL132378 | ChEMBL ↗ |
|
33826 ↗ |
O[C@@H]1[C@H](NC[C@@H]2COc3ccccc3O2)CC[C@H]1Oc1ccccc1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
6.17×103 | Ki | CHEMBL134428 | ChEMBL ↗ |
|
33827 ↗ |
O[C@@H]1[C@H](NC[C@H]2COc3ccccc3O2)CC[C@H]1Oc1ccccc1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
2.40×103 | Ki | CHEMBL135973 | ChEMBL ↗ |
|
33828 ↗ |
O[C@H]1[C@@H](NC[C@H]2COc3ccccc3O2)CC[C@@H]1Oc1ccccc1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
2.40×103 | Ki | CHEMBL135974 | ChEMBL ↗ |
|
33914 ↗ |
COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
227.00 | Ki | CHEMBL1729 | ChEMBL ↗ |
|
33962 ↗ |
O=C1c2ccccc2OCC1CN1CCC(Cc2ccccc2)CC1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
1.09×103 | Ki | CHEMBL178519 | ChEMBL ↗ |
|
33968 ↗ |
COc1cccc2c1CC(CN1CCC(Cc3ccccc3)CC1)CC2
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
866.00 | Ki | CHEMBL179371 | ChEMBL ↗ |
|
33969 ↗ |
c1ccc(CC2CCN(CC3COc4ccccc4C3)CC2)cc1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
2.49×103 | Ki | CHEMBL179373 | ChEMBL ↗ |
|
33971 ↗ |
c1ccc(CN2CCN(CC3CCc4ccccc4O3)CC2)cc1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
3.61 | Ki | CHEMBL179648 | ChEMBL ↗ |
|
33974 ↗ |
c1ccc(CC2CCN(CC3CCc4ccccc4C3)CC2)cc1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
1.15×103 | Ki | CHEMBL180327 | ChEMBL ↗ |
|
34162 ↗ |
COc1ccccc1N1CCN(CCCCN2C(=O)C[C@H](NC(=O)C3CCCC3)C2=O)CC1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
905.00 | Ki | CHEMBL207493 | ChEMBL ↗ |
|
34173 ↗ |
COc1ccccc1N1CCN(CCCCN2C(=O)C[C@H](NC(=O)C34CC5CC(CC(C5)C3)C4)C2=O)CC1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
1.77×103 | Ki | CHEMBL208905 | ChEMBL ↗ |
|
34176 ↗ |
COc1ccccc1N1CCN(CCCCN2C(=O)C[C@H](NC(=O)CC3CC4CCC3C4)C2=O)CC1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
880.00 | Ki | CHEMBL209007 | ChEMBL ↗ |
|
34198 ↗ |
O=c1ccc2ccc(OCCCCN3CCN(c4cccc5sccc45)CC3)cc2[nH]1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
3.80 | Ki | CHEMBL2105760 | ChEMBL ↗ |
|
34301 ↗ |
Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
3.98 | Ki | CHEMBL221692 | ChEMBL ↗ |
|
34323 ↗ |
CCCN(CCC)[C@H]1CCc2c(F)ccc(O)c2C1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
507.00 | Ki | CHEMBL22778 | ChEMBL ↗ |
|
34324 ↗ |
COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
2.80×103 | Ki | CHEMBL228082 | ChEMBL ↗ |
|
34348 ↗ |
C[C@H]1CN(c2cccc3cc(C#N)ccc23)CCN1CC[C@@H]1OCCc2cc(C(N)=O)ccc21
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
287.00 | Ki | CHEMBL233210 | ChEMBL ↗ |
|
34351 ↗ |
C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@H]1OCCc2cc(C(N)=O)ccc21
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
78.00 | Ki | CHEMBL234448 | ChEMBL ↗ |
|
34368 ↗ |
Cc1cc(=O)oc2c(Cl)c(OCCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
2.60 | Ki | CHEMBL2387229 | ChEMBL ↗ |
|
34371 ↗ |
O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
2.25×103 | Ki | CHEMBL238916 | ChEMBL ↗ |
|
34441 ↗ |
COc1cccc(OC)c1OCCNCC1COc2ccccc2O1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
123.03 | Ki | CHEMBL25554 | ChEMBL ↗ |
|
34459 ↗ |
COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
52.00 | Ki | CHEMBL268258 | ChEMBL ↗ |
|
34466 ↗ |
C[C@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
39.00 | Ki | CHEMBL27132 | ChEMBL ↗ |
|
34469 ↗ |
CN1CCc2ccc3c4c2[C@H]1Cc1cccc(c1-4)[C@@H]3N
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
2.25×103 | Ki | CHEMBL27251 | ChEMBL ↗ |
|
34479 ↗ |
COc1ccccc1N1CCN(CCCCN2C(=O)CCC2=O)CC1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
490.00 | Ki | CHEMBL279841 | ChEMBL ↗ |
|
34482 ↗ |
CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
7.00 | Ki | CHEMBL281924 | ChEMBL ↗ |
|
34485 ↗ |
C[C@@H]1c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
19.00 | Ki | CHEMBL282863 | ChEMBL ↗ |
|
34500 ↗ |
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
911.00 | Ki | CHEMBL300780 | ChEMBL ↗ |
|
34501 ↗ |
CCCN(CCC)C1CCc2ccc3[nH]cc(C=O)c3c2C1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
120.00 | Ki | CHEMBL304426 | ChEMBL ↗ |
|
34502 ↗ |
O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2c(c1)Cc1ccccc1-2
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
198.00 | Ki | CHEMBL304605 | ChEMBL ↗ |
|
34526 ↗ |
CCCN(CCC)C1CCc2ccc3occc3c2C1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
64.00 | Ki | CHEMBL314548 | ChEMBL ↗ |
|
34534 ↗ |
CN1CCN2c3c(cccc31)[C@@H]1CN(CCCc3noc4cc(F)ccc34)CC[C@@H]12
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
192.00 | Ki | CHEMBL3233412 | ChEMBL ↗ |
|
34535 ↗ |
O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCC3)c1ccc(F)cc1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
27.00 | Ki | CHEMBL3233427 | ChEMBL ↗ |
|
34536 ↗ |
O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCO3)c1ccc(F)cc1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
41.00 | Ki | CHEMBL3233432 | ChEMBL ↗ |
|
34606 ↗ |
CCCN1CC[C@H]2c3c(ccc4ccoc34)CC[C@H]21
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
150.00 | Ki | CHEMBL328107 | ChEMBL ↗ |
|
34875 ↗ |
CCCN(CCC)[C@H]1CCc2c(cccc2-c2c(OC)cccc2OC)C1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
1.21×103 | Ki | CHEMBL361875 | ChEMBL ↗ |
|
34882 ↗ |
COc1cccc(OC)c1-c1cccc2c1CC[C@H](N(C)C)C2
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
241.00 | Ki | CHEMBL363466 | ChEMBL ↗ |
|
34912 ↗ |
C[C@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@@H]1OCc2cc(C(N)=O)ccc21
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
26.00 | Ki | CHEMBL3706923 | ChEMBL ↗ |
|
34913 ↗ |
C[C@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@H]1OCc2cc(C(N)=O)ccc21
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
107.00 | Ki | CHEMBL3706924 | ChEMBL ↗ |
|
35034 ↗ |
COc1ccccc1N1CCN(CCCCN2C(=O)C[C@H](NC(=O)C3CCCCC3)C2=O)CC1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
2.08×103 | Ki | CHEMBL378298 | ChEMBL ↗ |
|
35080 ↗ |
O=c1ccc(OCCCN2CCC(c3noc4cc(F)ccc34)CC2)nn1-c1c(F)cccc1F
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
500.00×10-3 | Ki | CHEMBL3883955 | ChEMBL ↗ |
|
35126 ↗ |
C[C@@H]1CN(c2cccc3cc(F)ccc23)CCN1CC[C@@H]1OCCc2cc(C(N)=O)ccc21
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
71.00 | Ki | CHEMBL391271 | ChEMBL ↗ |
|
35127 ↗ |
C[C@H]1CN(c2ccc3cc(F)ccc3c2)CCN1CC[C@@H]1OCCc2cc(C(N)=O)ccc21
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
1.17×103 | Ki | CHEMBL391272 | ChEMBL ↗ |
|
35128 ↗ |
N#Cc1ccc2c(N3CCN(CC[C@@H]4OCCc5cc(C(N)=O)ccc54)CC3)cccc2c1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
88.00 | Ki | CHEMBL391273 | ChEMBL ↗ |
|
35328 ↗ |
CCCN(CCC)[C@H]1CCc2cccc(O)c2C1
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
5.07×103 | Ki | CHEMBL41436 | ChEMBL ↗ |
|
35573 ↗ |
O=C(CCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2
|
CHEMBL339 ↗
UniProt: P61169 ↗ |
10.30 | Ki | CHEMBL4289498 | ChEMBL ↗ |