CHEMBL344 IC50
BioactivityChEMBL CHEMBL344 IC50 bioactivity data
1565 compounds · Target: Melanin-concentrating hormone receptor 1 ( CHEMBL344 ↗ ) · UniProt: Q99705 ↗ · IC50
Melanin-concentrating hormone receptor 1, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
40164 ↗ |
O=C(Cc1ccccc1)NC1CCN(CCCN2C(=O)COc3ccccc32)CC1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
8.52×103 | IC50 | CHEMBL1242923 | ChEMBL ↗ |
|
40417 ↗ |
COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCC(c3cccc(NC(C)=O)c3)CC2)C(=O)N1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
3.00 | IC50 | CHEMBL185271 | ChEMBL ↗ |
|
42657 ↗ |
O=C1COc2ccccc2N1CCCN1CCC(c2noc3cc(F)ccc23)CC1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
3.24×103 | IC50 | CHEMBL4062602 | ChEMBL ↗ |
|
42668 ↗ |
COc1ccccc1N1CCN(CCCN2C(=O)COc3ccccc32)CC1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
5.15×103 | IC50 | CHEMBL4066435 | ChEMBL ↗ |
|
42725 ↗ |
O=C1COc2ccccc2N1CCCN1CCN(c2nsc3ccccc23)CC1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
4.18×103 | IC50 | CHEMBL4090568 | ChEMBL ↗ |
|
42736 ↗ |
O=C1COc2ccccc2N1CCCN1CCN(c2cccc(Cl)c2Cl)CC1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
1.87×103 | IC50 | CHEMBL4093980 | ChEMBL ↗ |
|
42763 ↗ |
O=C1COc2ccccc2N1CCCN1CCN(c2cccc3[nH]c(=O)oc23)CC1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
4.26×103 | IC50 | CHEMBL4104013 | ChEMBL ↗ |
|
53519 ↗ |
O=C(c1ccc(F)cc1)c1cc2n(c1)CCN(CCc1ccc(CN3CCCCC3)cc1)C2=O
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
150.00 | IC50 | CHEMBL217196 | ChEMBL ↗ |
|
66614 ↗ |
O=c1cc(OCc2ccccc2)ccn1-c1ccc(OCCN2CCCC2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
5.80 | IC50 | CHEMBL1641614 | ChEMBL ↗ |
|
66628 ↗ |
O=c1cc(OCc2ccccc2F)ccn1-c1ccc(OCCN2CCCC2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
8.70 | IC50 | CHEMBL1642471 | ChEMBL ↗ |
|
66629 ↗ |
O=c1cc(OCc2cccc(F)c2)ccn1-c1ccc(OCCN2CCCC2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
5.90 | IC50 | CHEMBL1642472 | ChEMBL ↗ |
|
66630 ↗ |
O=c1cc(OCc2cccc(Cl)c2)ccn1-c1ccc(OCCN2CCCC2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
4.20 | IC50 | CHEMBL1642474 | ChEMBL ↗ |
|
66631 ↗ |
O=c1cc(OCc2ccc(Cl)cc2)ccn1-c1ccc(OCCN2CCCC2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
1.40 | IC50 | CHEMBL1642475 | ChEMBL ↗ |
|
66632 ↗ |
COc1ccc(COc2ccn(-c3ccc(OCCN4CCCC4)cc3)c(=O)c2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
7.00 | IC50 | CHEMBL1642476 | ChEMBL ↗ |
|
66633 ↗ |
O=c1cc(OCc2ccc(C(F)(F)F)cc2)ccn1-c1ccc(OCCN2CCCC2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
6.70 | IC50 | CHEMBL1642477 | ChEMBL ↗ |
|
66634 ↗ |
O=c1cc(OCc2ccc3ccccc3c2)ccn1-c1ccc(OCCN2CCCC2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
7.70 | IC50 | CHEMBL1642479 | ChEMBL ↗ |
|
66635 ↗ |
O=c1cc(OCc2ccccc2)ccn1-c1ccc(OCCN2CCCCC2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
4.40 | IC50 | CHEMBL1642482 | ChEMBL ↗ |
|
66636 ↗ |
CCN(CC)CCOc1ccc(-n2ccc(OCc3ccccc3)cc2=O)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
6.60 | IC50 | CHEMBL1642485 | ChEMBL ↗ |
|
66637 ↗ |
CC(C)N(CCOc1ccc(-n2ccc(OCc3ccccc3)cc2=O)cc1)C(C)C
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
5.10 | IC50 | CHEMBL1642486 | ChEMBL ↗ |
|
66638 ↗ |
CN(CCOc1ccc(-n2ccc(OCc3ccccc3)cc2=O)cc1)Cc1ccccc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
3.80 | IC50 | CHEMBL1642487 | ChEMBL ↗ |
|
66639 ↗ |
CN1CCCCC1COc1ccc(-n2ccc(OCc3ccccc3)cc2=O)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
18.00 | IC50 | CHEMBL1642490 | ChEMBL ↗ |
|
66640 ↗ |
CN1CCCC1COc1ccc(-n2ccc(OCc3ccccc3)cc2=O)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
12.00 | IC50 | CHEMBL1642491 | ChEMBL ↗ |
|
66641 ↗ |
CCN(CC)CCNc1ccc(-n2ccc(OCc3ccccc3)cc2=O)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
6.80 | IC50 | CHEMBL1642492 | ChEMBL ↗ |
|
66642 ↗ |
CCN(CC)CCN(C)c1ccc(-n2ccc(OCc3ccccc3)cc2=O)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
16.00 | IC50 | CHEMBL1642493 | ChEMBL ↗ |
|
67161 ↗ |
CC(=O)Nc1cccc(C2CCN(CCCn3nc(-c4ccc(F)c(F)c4)c4ccccc4c3=O)CC2)c1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
1.00 | IC50 | CHEMBL1934835 | ChEMBL ↗ |
|
67191 ↗ |
O=c1cc(NC2CCN(Cc3ccc4c(c3)OCO4)CC2)c2cc(Cl)ccc2o1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
2.00 | IC50 | CHEMBL194564 | ChEMBL ↗ |
|
67333 ↗ |
Cc1nc(N2CCC(N3CCCC3)CC2)nc2ccc(NC(=O)COc3ccc(Cl)cc3)cc12
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
20.00 | IC50 | CHEMBL2016731 | ChEMBL ↗ |
|
67334 ↗ |
Cc1nc(N2CCC(N3CCCC3=O)CC2)nc2ccc(NC(=O)COc3ccc(OC(F)(F)F)cc3)cc12
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
19.00 | IC50 | CHEMBL2016776 | ChEMBL ↗ |
|
67365 ↗ |
Cc1nc(N2CCC(O)CC2)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
62.00 | IC50 | CHEMBL2017588 | ChEMBL ↗ |
|
67366 ↗ |
Cc1nc(N2CCC(O)(C3CC3)CC2)nc2ccc(NC(=O)/C=C/c3ccc(Cl)cc3)cc12
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
149.00 | IC50 | CHEMBL2017593 | ChEMBL ↗ |
|
67367 ↗ |
Cc1nc(N2CCC(O)(C3CC3)CC2)nc2ccc(NC(=O)/C=C/c3ccc(C(F)F)cc3)cc12
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
122.00 | IC50 | CHEMBL2017597 | ChEMBL ↗ |
|
67368 ↗ |
COCC(=O)NC1CCN(c2nc(C)c3cc(NC(=O)/C=C/c4ccc(Cl)cc4)ccc3n2)CC1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
45.00 | IC50 | CHEMBL2017760 | ChEMBL ↗ |
|
67581 ↗ |
O=C(NC1CCN(Cc2ccc3c(c2)OCO3)CC1)c1cc(=O)c2cc(Cl)c(Cl)cc2o1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
3.00 | IC50 | CHEMBL204828 | ChEMBL ↗ |
|
67587 ↗ |
COc1ccc2c(=O)cc(C(=O)NC3CCN(Cc4ccc5c(c4)OCO5)CC3)oc2c1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
8.50 | IC50 | CHEMBL206081 | ChEMBL ↗ |
|
67656 ↗ |
O=C(NC1CCN(Cc2ccc3c(c2)OCO3)CC1)c1cc(=O)c2ccc(OC(F)F)cc2o1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
64.00 | IC50 | CHEMBL213715 | ChEMBL ↗ |
|
67657 ↗ |
O=C(NC1CCN(Cc2ccccc2)CC1)c1cc(=O)c2ccc(F)cc2o1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
60.00 | IC50 | CHEMBL213761 | ChEMBL ↗ |
|
67659 ↗ |
CCc1ccc2c(=O)cc(C(=O)NC3CCN(Cc4ccc5c(c4)OCO5)CC3)oc2c1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
59.00 | IC50 | CHEMBL214377 | ChEMBL ↗ |
|
67660 ↗ |
CN(CC(=O)N(C)C)Cc1ccc2c(c1)CC[C@H](N(C)C(=O)c1ccc(-c3ccc(F)cc3)cc1)C2
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
24.00 | IC50 | CHEMBL214432 | ChEMBL ↗ |
|
67663 ↗ |
CCN(CC)Cc1ccc2c(c1)CC[C@H](N1CCN(CCc3ccc(F)cc3)CC1=O)C2
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
10.00 | IC50 | CHEMBL214629 | ChEMBL ↗ |
|
67734 ↗ |
O=C(NC1CCN(Cc2ccc3c(c2)OCO3)CC1)c1cc(=O)c2ccccc2o1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
66.00 | IC50 | CHEMBL214767 | ChEMBL ↗ |
|
67754 ↗ |
CCc1nc2ccc(CN3CCC(NC(=O)c4cc(=O)c5ccc(F)cc5o4)CC3)cc2o1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
1.27×103 | IC50 | CHEMBL215457 | ChEMBL ↗ |
|
67756 ↗ |
O=C(NC1CCN(Cc2ccc3c(c2)OCO3)CC1)c1cc(=O)c2ccc(O)cc2o1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
1.48×103 | IC50 | CHEMBL215631 | ChEMBL ↗ |
|
67798 ↗ |
O=C(NC1CCN(Cc2ccc3sccc3c2)CC1)c1cc(=O)c2ccc(F)cc2o1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
4.00 | IC50 | CHEMBL216104 | ChEMBL ↗ |
|
67800 ↗ |
O=C(NC1CCN(Cc2ccc3[nH]ccc3c2)CC1)c1cc(=O)c2ccc(F)cc2o1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
38.00 | IC50 | CHEMBL216180 | ChEMBL ↗ |
|
67801 ↗ |
O=C(NC1CCN(Cc2cccc(F)c2)CC1)c1cc(=O)c2ccc(F)cc2o1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
12.00 | IC50 | CHEMBL216225 | ChEMBL ↗ |
|
67803 ↗ |
O=C(NC1CCN(Cc2ccc3oc(=O)oc3c2)CC1)c1cc(=O)c2ccc(F)cc2o1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
2.01×103 | IC50 | CHEMBL216323 | ChEMBL ↗ |
|
67859 ↗ |
O=C(NC1CCN(Cc2ccc3ccc(=O)[nH]c3c2)CC1)c1cc(=O)c2ccc(F)cc2o1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
7.00 | IC50 | CHEMBL216482 | ChEMBL ↗ |
|
67878 ↗ |
O=C(NC1CCN(Cc2ccc3ncoc3c2)CC1)c1cc(=O)c2ccc(F)cc2o1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
10.00 | IC50 | CHEMBL216524 | ChEMBL ↗ |
|
67879 ↗ |
O=C(NC1CCN(Cc2ccc3occc3c2)CC1)c1cc(=O)c2ccc(F)cc2o1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
7.00 | IC50 | CHEMBL216554 | ChEMBL ↗ |
|
67898 ↗ |
O=C(NC1CCN(Cc2cc3c(cc2Cl)OCO3)CC1)c1cc(=O)c2ccc(F)cc2o1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
22.00 | IC50 | CHEMBL217105 | ChEMBL ↗ |