CHEMBL344 Ki
BioactivityChEMBL CHEMBL344 Ki bioactivity data
1064 compounds · Target: Melanin-concentrating hormone receptor 1 ( CHEMBL344 ↗ ) · UniProt: Q99705 ↗ · Ki
Melanin-concentrating hormone receptor 1, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
53600 ↗ |
COc1cc(NC(=O)c2ccc(-c3ccccc3)cc2)ccc1OCCN(C(C)C)C(C)C
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
31.62 | Ki | CHEMBL385254 | ChEMBL ↗ |
|
67658 ↗ |
CCN(CC)Cc1ccc2c(c1)CC[C@H](N1CCN(CCc3cccc(C(F)(F)F)c3)CC1=O)C2
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
93.00 | Ki | CHEMBL214323 | ChEMBL ↗ |
|
69218 ↗ |
COc1ccc(COc2cnn(CC(=O)c3ccc(CN(C)C)cc3C)c(=O)c2)nc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
14.00 | Ki | CHEMBL3601377 | ChEMBL ↗ |
|
69339 ↗ |
COc1cc(-n2cnn3cc(-c4ccc(Cl)cc4)cc3c2=O)ccc1OCCN1CCCC1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
500.00×10-3 | Ki | CHEMBL3618324 | ChEMBL ↗ |
|
69340 ↗ |
CNC1CCN(c2ccc(-n3cnn4cc(-c5ccc(Cl)cc5)cc4c3=O)cn2)C1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
400.00×10-3 | Ki | CHEMBL3618330 | ChEMBL ↗ |
|
69341 ↗ |
O=c1c2cc(-c3ccc(Cl)cc3)cn2ncn1-c1ccc(N2CC(O)C2)nc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
15.00 | Ki | CHEMBL3618331 | ChEMBL ↗ |
|
69342 ↗ |
O=c1c2cc(-c3ccc(Cl)cc3)cn2ncn1-c1ccc(N2CCC(N3CC(O)C3)C2)nc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
800.00×10-3 | Ki | CHEMBL3618334 | ChEMBL ↗ |
|
69685 ↗ |
CCN(CC)Cc1ccc2c(c1)CC[C@H](N1CCN(CCc3ccc(Cl)cc3)CC1=O)C2
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
4.00 | Ki | CHEMBL384400 | ChEMBL ↗ |
|
121276 ↗ |
CN(C)CCN(C(=O)Nc1ccc(F)c(Cl)c1)c1ccc(-c2cccc(C#N)c2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
3.30 | Ki | CHEMBL189147 | ChEMBL ↗ |
|
134837 ↗ |
O=C(NCC1(c2ccc(-c3cccnc3)cc2)CCNCC1)Nc1cc(Cl)cc(Cl)c1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
39.00 | Ki | CHEMBL175860 | ChEMBL ↗ |
|
134838 ↗ |
Cc1ccc(C2(CNC(=O)Nc3cc(Cl)cc(Cl)c3)CCN(C)CC2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
300.00 | Ki | CHEMBL175874 | ChEMBL ↗ |
|
134839 ↗ |
CN(C)CCC(CNC(=O)Nc1cc(F)cc(F)c1)c1ccc(-c2cccc(C#N)c2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
880.00×10-3 | Ki | CHEMBL175993 | ChEMBL ↗ |
|
134841 ↗ |
O=C(NCC(CCNC1CCCC1)c1ccc(-c2cccnc2)cc1)Nc1cc(Cl)cc(Cl)c1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
24.00 | Ki | CHEMBL176024 | ChEMBL ↗ |
|
134872 ↗ |
CCCN1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(c2ccc(-c3cccc(C#N)c3)cc2)CC1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
310.00×10-3 | Ki | CHEMBL176159 | ChEMBL ↗ |
|
134873 ↗ |
N#Cc1cccc(-c2ccc(C3(CNC(=O)Nc4cc(Cl)cc(Cl)c4)CCN(CC4CC4)CC3)cc2)c1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
170.00×10-3 | Ki | CHEMBL176219 | ChEMBL ↗ |
|
134874 ↗ |
O=C(NCC(CCN1CCC(N2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1)Nc1ccc(C(F)(F)F)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
1.08×103 | Ki | CHEMBL176230 | ChEMBL ↗ |
|
134876 ↗ |
CN(C)CCC(CNC(=O)Nc1ccccc1)c1ccc(-c2cccc(C#N)c2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
2.40 | Ki | CHEMBL176548 | ChEMBL ↗ |
|
134880 ↗ |
COCCN1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(c2ccc(-c3cccc(C#N)c3)cc2)CC1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
410.00×10-3 | Ki | CHEMBL178997 | ChEMBL ↗ |
|
134882 ↗ |
O=C(NCC(CCNC1CCCC1)c1ccc(-c2ccccc2)cc1)Nc1cc(Cl)cc(Cl)c1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
50.00 | Ki | CHEMBL179325 | ChEMBL ↗ |
|
134883 ↗ |
CN1CCC(CNC(=O)Nc2ccccc2)(c2ccc(-c3cccc(C#N)c3)cc2)CC1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
2.20 | Ki | CHEMBL179353 | ChEMBL ↗ |
|
134884 ↗ |
N#Cc1cccc(-c2ccc(C3(CNC(=O)Nc4cc(Cl)cc(Cl)c4)CCN(C4CCCCC4)CC3)cc2)c1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
1.20 | Ki | CHEMBL179437 | ChEMBL ↗ |
|
134887 ↗ |
O=C(NCC(CCNC1CCCC1)c1ccc(-c2ccc(Cl)cc2)cc1)Nc1cc(Cl)cc(Cl)c1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
280.00 | Ki | CHEMBL179872 | ChEMBL ↗ |
|
134890 ↗ |
Cc1cccc(NC(=O)NCC(CCN2CCC(N3CCCCC3)CC2)c2ccc(Cl)c(Cl)c2)c1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
6.80×103 | Ki | CHEMBL180009 | ChEMBL ↗ |
|
135028 ↗ |
N#Cc1cccc(-c2ccc(N(CCN3CCCC3)C(=O)Nc3ccc(C(F)(F)F)c(F)c3)cc2)c1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
5.60 | Ki | CHEMBL190780 | ChEMBL ↗ |
|
135325 ↗ |
N#Cc1cccc(-c2ccc(C(CCN3CCCCC3)CNC(=O)Nc3cc(Cl)cc(Cl)c3)cc2)c1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
5.40 | Ki | CHEMBL2112988 | ChEMBL ↗ |
|
135346 ↗ |
CN1CCN(CCCN(c2nc3cc(F)c(F)cc3[nH]2)[C@@H]2CC[C@]3(c4cccc(CN5CCN(C)CC5)c4)C[C@@H]3C2)CC1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
321.00 | Ki | CHEMBL214858 | ChEMBL ↗ |
|
135351 ↗ |
CN1CCN(CCCN(c2nc3cc(Cl)c(Cl)cc3[nH]2)[C@@H]2CC[C@]3(c4cccc(C#N)c4)C[C@@H]3C2)CC1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
2.20 | Ki | CHEMBL215030 | ChEMBL ↗ |
|
135367 ↗ |
CN1CCN(CCCN(c2nc3cc(F)c(F)cc3[nH]2)[C@@H]2CC[C@]3(c4cccc(C#N)c4)C[C@@H]3C2)CC1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
8.40 | Ki | CHEMBL215964 | ChEMBL ↗ |
|
135375 ↗ |
Cc1ccc(Oc2ccc(C(=O)NCCN3CCCC3)cc2NC(=O)Nc2ccccc2)cc1C
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
4.70 | Ki | CHEMBL216192 | ChEMBL ↗ |
|
135397 ↗ |
CN1CCN(CCCN(c2nc3cc(F)c(F)cc3[nH]2)[C@@H]2CC[C@]3(c4cccc(CN5CCC[C@H]5CO)c4)C[C@@H]3C2)CC1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
3.00×103 | Ki | CHEMBL217132 | ChEMBL ↗ |
|
135412 ↗ |
O=C1CN(CCc2ccccc2)CCN1CCc1ccc(CN2CCCCC2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
11.00 | Ki | CHEMBL217637 | ChEMBL ↗ |
|
135418 ↗ |
Fc1ccc(-c2ccc(CNCCc3ccc(CN4CCCCC4)cc3)cc2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
2.00×103 | Ki | CHEMBL228293 | ChEMBL ↗ |
|
135419 ↗ |
O=C1CN(C(=O)Cc2ccc(F)cc2)CCN1CCc1ccc(CN2CCCCC2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
1.20×103 | Ki | CHEMBL228294 | ChEMBL ↗ |
|
135420 ↗ |
CN(C)Cc1ccc(CCNC(=O)c2ccc(-c3ccc(F)cc3)cc2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
19.00 | Ki | CHEMBL228987 | ChEMBL ↗ |
|
135421 ↗ |
CN(C)Cc1ccc(CCN(C)C(=O)c2ccc(-c3ccc(F)cc3)cc2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
7.00 | Ki | CHEMBL229093 | ChEMBL ↗ |
|
135515 ↗ |
CN1CCN(CCCN(c2nc3cc(F)c(F)cc3[nH]2)[C@@H]2CC[C@]3(c4cccc(CN5CCCCC5)c4)C[C@@H]3C2)CC1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
405.00 | Ki | CHEMBL268385 | ChEMBL ↗ |
|
135644 ↗ |
CN1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(c2ccc(-c3cccc(C=O)c3)cc2)CC1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
5.50 | Ki | CHEMBL360731 | ChEMBL ↗ |
|
135648 ↗ |
CN(C)CCC(CNC(=O)Nc1ccc(F)c(Cl)c1)c1ccc(-c2cccc(C#N)c2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
980.00×10-3 | Ki | CHEMBL361215 | ChEMBL ↗ |
|
135709 ↗ |
CN1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(c2ccc(-c3cccnc3)cc2)CC1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
3.10 | Ki | CHEMBL367156 | ChEMBL ↗ |
|
135712 ↗ |
CN(C)CCC(CNC(=O)Nc1cccc(F)c1)c1ccc(-c2cccc(C#N)c2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
1.20 | Ki | CHEMBL367532 | ChEMBL ↗ |
|
135944 ↗ |
CN1CCN(CCCN(c2nc3cc(F)c(F)cc3[nH]2)[C@@H]2CC[C@]3(c4cccc(CO)c4)C[C@@H]3C2)CC1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
70.80 | Ki | CHEMBL386039 | ChEMBL ↗ |
|
135955 ↗ |
O=C(CCc1ccc(CN2CCCCC2)cc1)Nc1ccc(-c2ccc(F)cc2)cc1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
25.00 | Ki | CHEMBL388181 | ChEMBL ↗ |
|
135956 ↗ |
CCN(CC)Cc1ccc2c(c1)CC[C@H](N1CCN(CCc3ccc(C(F)(F)F)cc3)CC1=O)C2
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
42.00 | Ki | CHEMBL389618 | ChEMBL ↗ |
|
135988 ↗ |
CNC1CCN(c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2)C1
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
3.10 | Ki | CHEMBL426777 | ChEMBL ↗ |
|
136084 ↗ |
CCN(CCCN1CCC2(CC1)OCc1ccc(F)cc12)C(=O)C(c1ccc(F)c(F)c1)N1CCN([35S](C)(=O)=O)CC1=O
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
300.00×10-3 | Ki | CHEMBL538424 | ChEMBL ↗ |
|
136164 ↗ |
COC[C@H]1OC(OCc2ccc3ccccc3c2)[C@H](NC(=O)CCCN=C(N)N)[C@@H](OCc2ccc3ccccc3c2)[C@@H]1O
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
5.10×103 | Ki | CHEMBL1253625 | ChEMBL ↗ |
|
136165 ↗ |
COC[C@H]1OC(OCc2ccc3ccccc3c2)[C@H](NC(=O)CCN=C(N)N)[C@@H](OCc2ccc3ccccc3c2)[C@@H]1O
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
6.30×103 | Ki | CHEMBL1253626 | ChEMBL ↗ |
|
136166 ↗ |
COC[C@H]1OC(OCc2ccc(Cl)cc2)[C@H](NC(=O)CCCN=C(N)N)[C@@H](OCc2ccc(Cl)cc2)[C@@H]1O
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
1.20×103 | Ki | CHEMBL1254556 | ChEMBL ↗ |
|
136167 ↗ |
COC[C@H]1OC(OCc2ccc3ccccc3c2)[C@H](NC(=O)CCCN=C(N)N)[C@@H](OCc2ccc(Cl)cc2)[C@@H]1O
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
1.80×103 | Ki | CHEMBL1254630 | ChEMBL ↗ |
|
136168 ↗ |
COC[C@H]1OC(OCc2ccc(Cl)cc2)[C@H](NC(=O)CCCN=C(N)N)[C@@H](OCc2ccc3ccccc3c2)[C@@H]1O
|
CHEMBL344 ↗
UniProt: Q99705 ↗ |
2.60×103 | Ki | CHEMBL1254711 | ChEMBL ↗ |