CHEMBL3471 IC50
BioactivityChEMBL CHEMBL3471 IC50 bioactivity data
2410 compounds · Target: Human immunodeficiency virus type 1 integrase ( CHEMBL3471 ↗ ) · UniProt: Q7ZJM1 ↗ · IC50
Human immunodeficiency virus type 1 integrase, a molecular target studied in Human immunodeficiency virus 1.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
6570 ↗ |
O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
5.10×103 | IC50 | CHEMBL6246 | ChEMBL ↗ |
|
10543 ↗ |
O=C(CSc1nc(O)c2ccccc2n1)c1ccc(O)c(O)c1
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
82.00×103 | IC50 | CHEMBL240331 | ChEMBL ↗ |
|
14754 ↗ |
O=c1cc(-c2ccc(O)cc2)oc2cc(O)cc(O)c12
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
1.50×103 | IC50 | CHEMBL28 | ChEMBL ↗ |
|
15570 ↗ |
O=c1c(-c2ccc(O)cc2)coc2cc(O)cc(O)c12
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
1.10×103 | IC50 | CHEMBL44 | ChEMBL ↗ |
|
16141 ↗ |
O=C1C[C@@H](c2ccc(O)cc2)Oc2cc(O)cc(O)c21
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
1.70×103 | IC50 | CHEMBL9352 | ChEMBL ↗ |
|
19476 ↗ |
O=C(/C=C/c1ccc(O)cc1)c1ccc(O)cc1O
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
100.00×103 | IC50 | CHEMBL129795 | ChEMBL ↗ |
|
20840 ↗ |
COc1cc(/C=C/C(=O)/C=C(O)/C=C/c2ccc(O)c(OC)c2)ccc1O
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
33.40×103 | IC50 | CHEMBL116438 | ChEMBL ↗ |
|
26854 ↗ |
O=c1cc(-c2ccccc2)oc2cc(O)cc(O)c12
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
1.40×103 | IC50 | CHEMBL117 | ChEMBL ↗ |
|
30615 ↗ |
O=C(O)/C(O)=C/C(=O)c1ccccc1
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
24.20×103 | IC50 | CHEMBL467389 | ChEMBL ↗ |
|
31149 ↗ |
O=C(O)/C(O)=C/C(=O)c1cccn1Cc1ccc(F)cc1
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
68.50 | IC50 | CHEMBL499273 | ChEMBL ↗ |
|
32817 ↗ |
CCOC(=O)C1=C(O)/C(=C\c2ccc(CNC(=O)C(=O)Nc3ccccc3)o2)N=C1C
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
40.00×103 | IC50 | CHEMBL377295 | ChEMBL ↗ |
|
37093 ↗ |
COc1ccc(-c2c3c4cc(OC)c(O)cc4oc(=O)c3n3ccc4cc(O)c(OC)cc4c23)cc1O
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
18.50×103 | IC50 | CHEMBL301226 | ChEMBL ↗ |
|
73773 ↗ |
O=C(/C=C/c1ccc(O)c(O)c1)O[C@@H]1C[C@](O)(C(=O)O)C[C@@H](OC(=O)/C=C/c2ccc(O)c(O)c2)[C@H]1O
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
970.00 | IC50 | CHEMBL249447 | ChEMBL ↗ |
|
75845 ↗ |
O=C1C(O)=C(C(C2=C(O)C(=O)c3ccccc3C2=O)c2ccc(Cl)cc2Cl)C(=O)c2ccccc21
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
38.50×103 | IC50 | CHEMBL291663 | ChEMBL ↗ |
|
75916 ↗ |
O=C1Oc2ccccc2C(O)C1Sc1c(O)oc2ccccc2c1=O
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
90.00×103 | IC50 | CHEMBL303093 | ChEMBL ↗ |
|
76709 ↗ |
O=c1c(C(c2ccc3c(c2)OCO3)c2c(O)oc3ccccc3c2=O)c(O)oc2ccccc12
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
32.50×103 | IC50 | CHEMBL64213 | ChEMBL ↗ |
|
76713 ↗ |
CCCCCCc1cc2c(cc1O)OC(=O)C(C(c1ccccc1)c1c(O)oc3cc(O)c(CCCCCC)cc3c1=O)C2O
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
11.25×103 | IC50 | CHEMBL64802 | ChEMBL ↗ |
|
76784 ↗ |
O=C1C(=O)c2ccccc2C(O)=C1Cc1ccc(Cl)cc1
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
74.00×103 | IC50 | CHEMBL79687 | ChEMBL ↗ |
|
76792 ↗ |
CCCCCCC/N=C1/C(=O)c2ccccc2C(O)=C1O
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
100.00×103 | IC50 | CHEMBL82611 | ChEMBL ↗ |
|
76793 ↗ |
O=C1C(=O)c2ccccc2C(O)=C1CSc1ccc(Cl)cc1
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
100.00×103 | IC50 | CHEMBL83730 | ChEMBL ↗ |
|
80903 ↗ |
O=C(Nc1ccc2c(O)c(/N=N/c3ccc(C(=O)O)cc3)c(S(=O)(=O)O)cc2c1)Nc1ccc2c(O)c(/N=N/c3ccc(C(=O)O)cc3)c(S(=O)(=O)O)cc2c1
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
700.00 | IC50 | CHEMBL1161970 | ChEMBL ↗ |
|
80904 ↗ |
CC(C)c1c(Cc2ccccc2)n(COCc2ccc(Cc3cccc(C(=O)/C=C(\O)C(=O)O)c3)cc2)c(=O)[nH]c1=O
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
11.00×103 | IC50 | CHEMBL1163165 | ChEMBL ↗ |
|
80905 ↗ |
CCc1c(Cc2cc(C)cc(C)c2)n(COCc2ccc(Cc3cccc(C(=O)/C=C(\O)C(=O)O)c3)cc2)c(=O)[nH]c1=O
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
14.00×103 | IC50 | CHEMBL1163166 | ChEMBL ↗ |
|
80906 ↗ |
CCc1c(Cc2ccccc2)n(COCc2ccc(Cc3cccc(C(=O)/C=C(\O)C(=O)O)c3)cc2)c(=O)[nH]c1=O
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
16.00×103 | IC50 | CHEMBL1163681 | ChEMBL ↗ |
|
80907 ↗ |
Cc1cc(C)cc(Cc2c(C(C)C)c(=O)[nH]c(=O)n2COCc2ccc(Cc3cccc(C(=O)/C=C(\O)C(=O)O)c3)cc2)c1
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
22.00×103 | IC50 | CHEMBL1164684 | ChEMBL ↗ |
|
81015 ↗ |
O=c1ccc2cccnc2n1O
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
15.00×103 | IC50 | CHEMBL1269478 | ChEMBL ↗ |
|
81022 ↗ |
O=c1cc(-c2cccc(-c3ccccc3)c2)c2cccnc2n1O
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
2.40×103 | IC50 | CHEMBL1270317 | ChEMBL ↗ |
|
81024 ↗ |
NCc1ccccc1-c1cccc(-c2cc(=O)n(O)c3ncccc23)c1
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
18.00×103 | IC50 | CHEMBL1270416 | ChEMBL ↗ |
|
81025 ↗ |
NCc1cccc(-c2cccc(-c3cc(=O)n(O)c4ncccc34)c2)c1
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
9.10×103 | IC50 | CHEMBL1270417 | ChEMBL ↗ |
|
81026 ↗ |
NCc1ccc(-c2cccc(-c3cc(=O)n(O)c4ncccc34)c2)cc1
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
7.80×103 | IC50 | CHEMBL1270510 | ChEMBL ↗ |
|
81027 ↗ |
NCc1ccc(-c2cccc(Cc3cc(=O)n(O)c4ncccc34)c2)cc1
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
8.10×103 | IC50 | CHEMBL1270511 | ChEMBL ↗ |
|
81028 ↗ |
NCc1ccc(-c2ccc(Cc3cc(=O)n(O)c4ncccc34)cc2)cc1
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
24.00×103 | IC50 | CHEMBL1270611 | ChEMBL ↗ |
|
81163 ↗ |
O=C(O)C(=O)/C=C(\O)c1ccccc1
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
77.00×103 | IC50 | CHEMBL16326 | ChEMBL ↗ |
|
81220 ↗ |
CCCCCCc1c(O)n(O)c(=O)c2ccccc12
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
45.40×103 | IC50 | CHEMBL1668658 | ChEMBL ↗ |
|
81221 ↗ |
CCCCCCCc1c(O)n(O)c(=O)c2ccccc12
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
113.10×103 | IC50 | CHEMBL1668659 | ChEMBL ↗ |
|
81222 ↗ |
CC1C(=O)N(O)C(=O)c2ccccc21
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
3.30×103 | IC50 | CHEMBL1668660 | ChEMBL ↗ |
|
81223 ↗ |
CCC1C(=O)N(O)C(=O)c2ccccc21
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
15.70×103 | IC50 | CHEMBL1668661 | ChEMBL ↗ |
|
81224 ↗ |
CCCC1C(=O)N(O)C(=O)c2ccccc21
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
21.10×103 | IC50 | CHEMBL1668662 | ChEMBL ↗ |
|
81225 ↗ |
CC(C)C1C(=O)N(O)C(=O)c2ccccc21
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
35.50×103 | IC50 | CHEMBL1668663 | ChEMBL ↗ |
|
81226 ↗ |
CCCCC1C(=O)N(O)C(=O)c2ccccc21
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
40.20×103 | IC50 | CHEMBL1668664 | ChEMBL ↗ |
|
81227 ↗ |
CCCCCC1C(=O)N(O)C(=O)c2ccccc21
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
1.35×103 | IC50 | CHEMBL1668665 | ChEMBL ↗ |
|
81228 ↗ |
CCCCCCC1C(=O)N(O)C(=O)c2ccccc21
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
11.40×103 | IC50 | CHEMBL1668666 | ChEMBL ↗ |
|
81229 ↗ |
O=c1c2ccccc2c(Cc2ccccc2)c(O)n1O
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
39.90×103 | IC50 | CHEMBL1668668 | ChEMBL ↗ |
|
81230 ↗ |
Cc1ccc(CC2C(=O)N(O)C(=O)c3ccccc32)cc1
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
3.40×103 | IC50 | CHEMBL1668669 | ChEMBL ↗ |
|
81231 ↗ |
O=C1c2ccccc2C(Cc2ccc(C(F)(F)F)cc2)C(=O)N1O
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
23.20×103 | IC50 | CHEMBL1668670 | ChEMBL ↗ |
|
81232 ↗ |
O=C1c2ccccc2C(CCCc2ccccc2)C(=O)N1O
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
2.60×103 | IC50 | CHEMBL1668672 | ChEMBL ↗ |
|
81321 ↗ |
CCc1c(C(=O)c2ccccc2)n(COCc2ccccc2)c(=O)n(O)c1=O
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
37.00×103 | IC50 | CHEMBL1761471 | ChEMBL ↗ |
|
81322 ↗ |
CCc1c(C(=O)c2ccccc2)n(COCc2ccc(F)cc2)c(=O)n(O)c1=O
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
25.00×103 | IC50 | CHEMBL1761472 | ChEMBL ↗ |
|
81323 ↗ |
CCc1c(C(=O)c2cc(C)cc(C)c2)n(COCc2ccc(F)cc2)c(=O)n(O)c1=O
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
21.00×103 | IC50 | CHEMBL1761473 | ChEMBL ↗ |
|
81324 ↗ |
CCc1c(C(=O)c2cc(C)cc(C)c2)n(COCc2ccccc2)c(=O)n(O)c1=O
|
CHEMBL3471 ↗
UniProt: Q7ZJM1 ↗ |
41.00×103 | IC50 | CHEMBL1761474 | ChEMBL ↗ |