CHEMBL3650 IC50
BioactivityChEMBL CHEMBL3650 IC50 bioactivity data
1236 compounds · Target: Fibroblast growth factor receptor 1 ( CHEMBL3650 ↗ ) · UniProt: P11362 ↗ · IC50
Fibroblast growth factor receptor 1, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
5378 ↗ |
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
880.00 | IC50 | CHEMBL1421 | ChEMBL ↗ |
|
5480 ↗ |
CONC(=O)c1cc(Nc2ncnn3cc(NC(=O)OCCCS(C)(=O)=O)c(C(C)C)c23)c(F)cc1F
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
58.00 | IC50 | CHEMBL195218 | ChEMBL ↗ |
|
5863 ↗ |
CONC(=O)c1cc(Nc2ncnn3cc(-c4nnc(C)o4)c(C(C)C)c23)c(F)cc1F
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
19.00 | IC50 | CHEMBL365318 | ChEMBL ↗ |
|
5930 ↗ |
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
3.16 | IC50 | CHEMBL388978 | ChEMBL ↗ |
|
6215 ↗ |
OC[C@H](Nc1cnc(-c2cc(Cl)ccc2O)c(-c2ccc3cnccc3c2)c1)c1ccccc1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
16.10 | IC50 | CHEMBL4067871 | ChEMBL ↗ |
|
6221 ↗ |
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3ccc(F)cc3O)cc12
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
25.20 | IC50 | CHEMBL4075917 | ChEMBL ↗ |
|
6245 ↗ |
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(Cl)ccc3O)cc12
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
55.80 | IC50 | CHEMBL4105329 | ChEMBL ↗ |
|
6294 ↗ |
CN(CCc1ccc(-c2ccccc2)cc1)Cc1cn(C)c2ccc(C(=O)Nc3ccc(F)cc3)cc12
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
13.00×103 | IC50 | CHEMBL4446681 | ChEMBL ↗ |
|
6320 ↗ |
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
750.00 | IC50 | CHEMBL458997 | ChEMBL ↗ |
|
6386 ↗ |
Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
7.00 | IC50 | CHEMBL4798527 | ChEMBL ↗ |
|
7292 ↗ |
Cc1c2ccc(N(C)c3ccnc(Nc4ccc(C(=O)Nc5ccccc5N)cc4)n3)cc2nn1C
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
192.00 | IC50 | CHEMBL4213341 | ChEMBL ↗ |
|
8936 ↗ |
Cc1c2ccc(N(C)c3ccnc(Nc4ccc(C(=O)NCCCCCCC(=O)NO)cc4)n3)cc2nn1C
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
409.00 | IC50 | CHEMBL4212117 | ChEMBL ↗ |
|
10032 ↗ |
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCCCCCC(=O)NO)c4)nc3c2)c1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
180.00×10-3 | IC50 | CHEMBL5177696 | ChEMBL ↗ |
|
10038 ↗ |
COc1cc(OC)cc(N(CCCCCC(=O)NO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
18.00 | IC50 | CHEMBL5179582 | ChEMBL ↗ |
|
10050 ↗ |
COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(CCOc5ccc(C(=O)NO)cc5)c4)nc3c2)c1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
240.00×10-3 | IC50 | CHEMBL5181688 | ChEMBL ↗ |
|
16199 ↗ |
Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
4.30×103 | IC50 | CHEMBL1614712 | ChEMBL ↗ |
|
16222 ↗ |
Nc1ncnc2c1c(-c1cccc(O)c1)cn2C1CCCC1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
990.00 | IC50 | CHEMBL169390 | ChEMBL ↗ |
|
16283 ↗ |
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
4.06×103 | IC50 | CHEMBL2006765 | ChEMBL ↗ |
|
16305 ↗ |
Cc1cc(CNc2ncc(Br)c(Nc3cc(C)[nH]n3)n2)on1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
110.80 | IC50 | CHEMBL2088091 | ChEMBL ↗ |
|
16310 ↗ |
Cc1cc(CNc2ncc(Cl)c(Nc3cc(C)[nH]n3)n2)on1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
31.62 | IC50 | CHEMBL2088097 | ChEMBL ↗ |
|
16311 ↗ |
Cc1cc(CNc2nccc(Nc3cc(C)[nH]n3)n2)on1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
79.43 | IC50 | CHEMBL2088098 | ChEMBL ↗ |
|
16312 ↗ |
COCCCc1cc(Nc2ccnc(NCc3cc(C)no3)n2)n[nH]1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
79.43 | IC50 | CHEMBL2088099 | ChEMBL ↗ |
|
16313 ↗ |
Cc1cc(CNc2nccc(Nc3cc(CCc4ccccc4)[nH]n3)n2)on1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
7.94 | IC50 | CHEMBL2088100 | ChEMBL ↗ |
|
16314 ↗ |
Cc1cc(Nc2nc(NCc3ccccn3)ncc2Br)n[nH]1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
199.53 | IC50 | CHEMBL2088101 | ChEMBL ↗ |
|
16315 ↗ |
Cc1cc(Nc2nc(NCCCc3c[nH]nc3C)ncc2Br)n[nH]1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
125.89 | IC50 | CHEMBL2088102 | ChEMBL ↗ |
|
16316 ↗ |
Cc1cc(Nc2nc(NCCc3ccco3)ncc2Br)n[nH]1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
199.53 | IC50 | CHEMBL2088103 | ChEMBL ↗ |
|
16317 ↗ |
Cc1cnc(CNc2ncc(Br)c(Nc3cc(C)[nH]n3)n2)cn1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
100.00 | IC50 | CHEMBL2088104 | ChEMBL ↗ |
|
16318 ↗ |
Cc1cc(CCNc2ncc(Br)c(Nc3cc(C)[nH]n3)n2)on1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
398.11 | IC50 | CHEMBL2088105 | ChEMBL ↗ |
|
16319 ↗ |
Cc1cc(Nc2nc(NCc3ncccc3C)ncc2Br)n[nH]1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
79.43 | IC50 | CHEMBL2088106 | ChEMBL ↗ |
|
16320 ↗ |
Cc1cc(Nc2nc(NCc3cc(C(=O)N4CCCC4)no3)ncc2Br)n[nH]1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
5.01×103 | IC50 | CHEMBL2088107 | ChEMBL ↗ |
|
16321 ↗ |
Cc1cc(Nc2ccnc(NCc3cc(C4CC4)no3)n2)n[nH]1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
25.12 | IC50 | CHEMBL2088108 | ChEMBL ↗ |
|
16322 ↗ |
Cc1cc(Nc2ccnc(NCc3cc(C(N)=O)no3)n2)n[nH]1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
100.00 | IC50 | CHEMBL2088109 | ChEMBL ↗ |
|
16323 ↗ |
Cc1cc(CNc2nccc(Nc3cc(CO)[nH]n3)n2)on1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
794.33 | IC50 | CHEMBL2088110 | ChEMBL ↗ |
|
16324 ↗ |
CCc1cc(Nc2nc(NCc3ccccn3)ncc2Br)n[nH]1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
39.81 | IC50 | CHEMBL2088111 | ChEMBL ↗ |
|
16325 ↗ |
CCc1cc(Nc2nc(NCc3cc(-c4ccccn4)no3)ncc2Br)n[nH]1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
79.43 | IC50 | CHEMBL2088112 | ChEMBL ↗ |
|
16326 ↗ |
CCCc1cc(Nc2nc(NCc3cccnc3)ncc2Br)n[nH]1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
25.12 | IC50 | CHEMBL2088113 | ChEMBL ↗ |
|
16327 ↗ |
CC(C)c1cc(Nc2nc(NCc3cccnc3)ncc2Br)n[nH]1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
63.10 | IC50 | CHEMBL2088256 | ChEMBL ↗ |
|
16328 ↗ |
COCCCc1cc(Nc2ccnc(NCc3cc(C4CC4)no3)n2)n[nH]1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
25.12 | IC50 | CHEMBL2088257 | ChEMBL ↗ |
|
16329 ↗ |
COCCCc1cc(Nc2ccnc(NCc3cc(C(N)=O)no3)n2)n[nH]1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
63.10 | IC50 | CHEMBL2088258 | ChEMBL ↗ |
|
16330 ↗ |
COc1cc(CCc2cc(Nc3ccnc(NCc4ccccn4)n3)n[nH]2)cc(OC)c1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
5.01 | IC50 | CHEMBL2088259 | ChEMBL ↗ |
|
16331 ↗ |
COc1cc(CCc2cc(Nc3ccnc(NCc4cc(C)on4)n3)n[nH]2)cc(OC)c1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
2.00 | IC50 | CHEMBL2088260 | ChEMBL ↗ |
|
16342 ↗ |
O=C1Nc2ccccc2/C1=C1/Nc2ccccc2/C1=N\O
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
2.50×103 | IC50 | CHEMBL216543 | ChEMBL ↗ |
|
17551 ↗ |
Nc1n[nH]c2cccc(-c3ccc(NC(=S)Nc4cc(Br)ccc4OC(F)(F)F)cc3)c12
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
167.00 | IC50 | CHEMBL4160854 | ChEMBL ↗ |
|
17553 ↗ |
C=CC(=O)Nc1ccc(-c2ccc(NC(=O)Nc3cccc(Cl)c3)cc2)cn1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
200.00 | IC50 | CHEMBL4171543 | ChEMBL ↗ |
|
17592 ↗ |
COc1ccc(-c2cnn3c(N)c(-c4nccs4)c(OC4CCN(C)CC4)nc23)cc1OC
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
3.10×103 | IC50 | CHEMBL4636995 | ChEMBL ↗ |
|
17611 ↗ |
Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CO)C1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
2.10×103 | IC50 | CHEMBL4858720 | ChEMBL ↗ |
|
17677 ↗ |
CC(C)OCc1ccc2c(c1)c1c3c(c4c(c1n2CCCO)Cc1ccccc1-4)C(=O)NC3
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
162.00 | IC50 | CHEMBL150894 | ChEMBL ↗ |
|
17697 ↗ |
CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(-c4cnn(C)c4)cc3c(=O)c2c1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
65.00 | IC50 | CHEMBL1822792 | ChEMBL ↗ |
|
17726 ↗ |
CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
13.00 | IC50 | CHEMBL2010872 | ChEMBL ↗ |
|
17835 ↗ |
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1
|
CHEMBL3650 ↗
UniProt: P11362 ↗ |
5.48×103 | IC50 | CHEMBL223360 | ChEMBL ↗ |