CHEMBL3759 Ki
BioactivityChEMBL CHEMBL3759 Ki bioactivity data
1056 compounds · Target: Histamine H4 receptor ( CHEMBL3759 ↗ ) · UniProt: Q9H3N8 ↗ · Ki
Histamine H4 receptor, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
35817 ↗ |
CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
1.89×103 | Ki | CHEMBL4520788 | ChEMBL ↗ |
|
40148 ↗ |
Clc1cccc(N2CCN(CCCCNc3ccc4ccccc4n3)CC2)c1Cl
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
125.00 | Ki | CHEMBL1223683 | ChEMBL ↗ |
|
40150 ↗ |
COc1ccccc1N1CCN(CCCCNc2nccc3ccccc23)CC1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
51.00 | Ki | CHEMBL1223748 | ChEMBL ↗ |
|
40151 ↗ |
Clc1cccc(N2CCN(CCCCNc3nccc4ccccc34)CC2)c1Cl
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
5.20 | Ki | CHEMBL1223749 | ChEMBL ↗ |
|
40152 ↗ |
FC(F)(F)c1cccc(N2CCN(CCCCNc3nccc4ccccc34)CC2)c1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
5.40 | Ki | CHEMBL1223750 | ChEMBL ↗ |
|
40271 ↗ |
O=c1[nH]c2ccccc2n1C1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
2.00×103 | Ki | CHEMBL1423 | ChEMBL ↗ |
|
40906 ↗ |
CC1=CC(C)=[N+]2C1=C(c1ccc(OCCCN3CCCCC3)cc1)c1c(C)cc(C)n1[B-]2(F)F
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
7.48×103 | Ki | CHEMBL2323582 | ChEMBL ↗ |
|
43178 ↗ |
Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCCc1ccccc1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
776.25 | Ki | CHEMBL4846201 | ChEMBL ↗ |
|
43179 ↗ |
Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1ccco1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
45.71×103 | Ki | CHEMBL4846380 | ChEMBL ↗ |
|
43183 ↗ |
Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)C1CCCCC1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
1.91×103 | Ki | CHEMBL4846638 | ChEMBL ↗ |
|
43190 ↗ |
CCC(CNC(=O)/N=C(\N)NCCCc1sc(N)nc1C)c1ccccc1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
6.76×103 | Ki | CHEMBL4848815 | ChEMBL ↗ |
|
43211 ↗ |
Cc1ccc(CC(C)CNC(=O)/N=C(\N)NCCCc2sc(N)nc2C)cc1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
3.63×103 | Ki | CHEMBL4853107 | ChEMBL ↗ |
|
43216 ↗ |
CCCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
8.13×103 | Ki | CHEMBL4853668 | ChEMBL ↗ |
|
43217 ↗ |
Cc1nc(N)sc1CCCN/C(N)=N/C(=S)N[C@H](C)c1ccccc1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
26.92×103 | Ki | CHEMBL4853772 | ChEMBL ↗ |
|
43234 ↗ |
Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCc1ccccc1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
19.05×103 | Ki | CHEMBL4856005 | ChEMBL ↗ |
|
43235 ↗ |
Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@H](C)c1ccccc1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
13.49×103 | Ki | CHEMBL4856059 | ChEMBL ↗ |
|
43239 ↗ |
Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CC1CCCCC1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
3.72×103 | Ki | CHEMBL4857560 | ChEMBL ↗ |
|
43252 ↗ |
CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
4.27×103 | Ki | CHEMBL4860528 | ChEMBL ↗ |
|
43283 ↗ |
Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NCC(C)CCc1ccccc1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
3.24×103 | Ki | CHEMBL4865765 | ChEMBL ↗ |
|
43286 ↗ |
Cc1nc(N)sc1CCCN/C(N)=N/C(=O)N[C@@H](C)c1ccccc1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
17.78×103 | Ki | CHEMBL4867962 | ChEMBL ↗ |
|
43302 ↗ |
CCCCCCNC(=O)/N=C(\N)Nc1cccc(-c2csc(N)n2)c1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
9.55×103 | Ki | CHEMBL4872375 | ChEMBL ↗ |
|
43312 ↗ |
Cc1nc(N)sc1CCCN/C(N)=N/C(=O)NC(C)c1cccc(F)c1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
13.18×103 | Ki | CHEMBL4875600 | ChEMBL ↗ |
|
43320 ↗ |
CCCCCCNC(=O)/N=C(\N)NC1CCc2nc(N)sc2C1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
16.60×103 | Ki | CHEMBL4876799 | ChEMBL ↗ |
|
43326 ↗ |
N/C(=N\C(=O)NCc1ccccc1)NC1CCc2nc(N)sc2C1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
30.20×103 | Ki | CHEMBL4878215 | ChEMBL ↗ |
|
47381 ↗ |
CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
188.68 | Ki | CHEMBL42 | ChEMBL ↗ |
|
47501 ↗ |
CN1CCN(C2=Nc3ccccc3Oc3ccc(Cl)cc32)CC1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
4.57×103 | Ki | CHEMBL831 | ChEMBL ↗ |
|
59080 ↗ |
COc1ccc2c(c1)c(CC(=O)NCCCO)c(C)n2C(=O)c1ccc(Cl)cc1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
7.78×103 | Ki | CHEMBL25725 | ChEMBL ↗ |
|
63551 ↗ |
O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc(Br)c1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
3.10×103 | Ki | CHEMBL4078910 | ChEMBL ↗ |
|
63553 ↗ |
COc1cc2c(cc1OC)C(C)=C(C(=O)NCCCCN1CCN(c3ccccc3F)CC1)C2
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
3.80×103 | Ki | CHEMBL4099779 | ChEMBL ↗ |
|
72337 ↗ |
c1ccc(C(OCCCc2c[nH]cn2)c2ccccc2)cc1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
25.00 | Ki | CHEMBL1179089 | ChEMBL ↗ |
|
72517 ↗ |
CN[C@@H]1CCN(c2cc(NCC3CC3)nc(N)n2)C1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
8.20 | Ki | CHEMBL1915540 | ChEMBL ↗ |
|
72545 ↗ |
Nc1nc(N2CCNCC2)c2ccc(-c3ccco3)cc2n1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
15.57 | Ki | CHEMBL1935574 | ChEMBL ↗ |
|
72703 ↗ |
Nc1nc(N2CCNCC2)c2ccc(C3CCCC3)cc2n1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
12.30 | Ki | CHEMBL2376789 | ChEMBL ↗ |
|
72704 ↗ |
CNC1CN(c2nc(N)nc3cc(C4CCCC4)ccc23)C1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
3.39 | Ki | CHEMBL2376790 | ChEMBL ↗ |
|
72705 ↗ |
Nc1nc(N2CCNCC2)c2ccc(C3CC3)cc2n1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
11.48 | Ki | CHEMBL2376793 | ChEMBL ↗ |
|
72706 ↗ |
CNC1CN(c2nc(N)nc3cc(C4CC4)ccc23)C1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
7.08 | Ki | CHEMBL2376794 | ChEMBL ↗ |
|
72707 ↗ |
CCc1ccc2c(N3CCNCC3)nc(N)nc2c1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
14.79 | Ki | CHEMBL2376795 | ChEMBL ↗ |
|
72708 ↗ |
CCc1ccc2c(N3CC(NC)C3)nc(N)nc2c1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
11.22 | Ki | CHEMBL2376796 | ChEMBL ↗ |
|
72709 ↗ |
CCc1ccc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
16.98 | Ki | CHEMBL2376797 | ChEMBL ↗ |
|
72710 ↗ |
CCc1cnc2c(N3CCN(C)CC3)nc(N)nc2c1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
9.33 | Ki | CHEMBL2376799 | ChEMBL ↗ |
|
72711 ↗ |
CCc1cnc2c(N3CC(NC)C3)nc(N)nc2c1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
10.72 | Ki | CHEMBL2376800 | ChEMBL ↗ |
|
72712 ↗ |
CCc1cnc2c(N3CC[C@@H](NC)C3)nc(N)nc2c1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
9.12 | Ki | CHEMBL2376801 | ChEMBL ↗ |
|
72713 ↗ |
CNC1CN(c2nc(N)nc3cc(C(C)C)cnc23)C1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
25.12 | Ki | CHEMBL2376805 | ChEMBL ↗ |
|
95786 ↗ |
c1ccc(COC[C@H]2CC[C@H](c3c[nH]cn3)O2)cc1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
1.00×103 | Ki | CHEMBL105803 | ChEMBL ↗ |
|
95787 ↗ |
C/N=C(\NC#N)NC[C@@H]1CC[C@H](c2c[nH]cn2)O1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
199.53 | Ki | CHEMBL106158 | ChEMBL ↗ |
|
95788 ↗ |
C/N=C(\NC#N)NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
19.95×103 | Ki | CHEMBL106570 | ChEMBL ↗ |
|
95789 ↗ |
NC[C@H]1CC[C@H](c2c[nH]cn2)O1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
794.33 | Ki | CHEMBL106612 | ChEMBL ↗ |
|
95790 ↗ |
NC[C@H]1CC[C@@H](c2c[nH]cn2)O1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
6.31×103 | Ki | CHEMBL106913 | ChEMBL ↗ |
|
95791 ↗ |
NC[C@@H]1CC[C@@H](c2c[nH]cn2)O1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
12.59×103 | Ki | CHEMBL106931 | ChEMBL ↗ |
|
95793 ↗ |
CC[C@H](C)CNC(=O)OCCCc1c[nH]cn1
|
CHEMBL3759 ↗
UniProt: Q9H3N8 ↗ |
118.00 | Ki | CHEMBL1076267 | ChEMBL ↗ |