CHEMBL3884 IC50
BioactivityChEMBL CHEMBL3884 IC50 bioactivity data
1141 compounds · Target: Sodium/glucose cotransporter 2 ( CHEMBL3884 ↗ ) · UniProt: P31639 ↗ · IC50
Sodium/glucose cotransporter 2, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
33295 ↗ |
O=C(CCc1ccc(O)cc1)c1c(O)cc(O)cc1O
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
18.30×103 | IC50 | CHEMBL45068 | ChEMBL ↗ |
|
146020 ↗ |
COc1ccc(Cc2cc([C@@H]3O[C@H](CO)C[C@H](O)[C@H]3O)ccc2Cl)cc1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
21.00 | IC50 | CHEMBL1077231 | ChEMBL ↗ |
|
146021 ↗ |
OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(N4CCOCC4)nn3)c2)[C@H](O)[C@@H](O)[C@@H]1O
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
700.00 | IC50 | CHEMBL1082416 | ChEMBL ↗ |
|
146022 ↗ |
OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(Nc4ccccc4)nn3)c2)[C@H](O)[C@@H](O)[C@@H]1O
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
1.14×103 | IC50 | CHEMBL1082417 | ChEMBL ↗ |
|
146023 ↗ |
OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(N4CCCC4)nn3)c2)[C@H](O)[C@@H](O)[C@@H]1O
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
1.04×103 | IC50 | CHEMBL1082502 | ChEMBL ↗ |
|
146024 ↗ |
OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(Cl)nn3)c2)[C@H](O)[C@@H](O)[C@@H]1O
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
202.00 | IC50 | CHEMBL1082759 | ChEMBL ↗ |
|
146025 ↗ |
CCc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@@H](O)[C@H]3O)ccc2C)cc1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
3.70×103 | IC50 | CHEMBL1082892 | ChEMBL ↗ |
|
146026 ↗ |
CCc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)nn1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
131.00 | IC50 | CHEMBL1083079 | ChEMBL ↗ |
|
146027 ↗ |
CCCc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)nn1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
237.00 | IC50 | CHEMBL1083369 | ChEMBL ↗ |
|
146028 ↗ |
CC(C)c1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)nn1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
259.00 | IC50 | CHEMBL1083370 | ChEMBL ↗ |
|
146029 ↗ |
CCCCc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)nn1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
356.00 | IC50 | CHEMBL1083671 | ChEMBL ↗ |
|
146030 ↗ |
OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(C#Cc4ccccc4)nn3)c2)[C@H](O)[C@@H](O)[C@@H]1O
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
176.00 | IC50 | CHEMBL1083673 | ChEMBL ↗ |
|
146031 ↗ |
OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(-c4ccco4)nn3)c2)[C@H](O)[C@@H](O)[C@@H]1O
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
64.30 | IC50 | CHEMBL1083674 | ChEMBL ↗ |
|
146032 ↗ |
CCOc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)nn1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
43.00 | IC50 | CHEMBL1083690 | ChEMBL ↗ |
|
146033 ↗ |
COc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3OC)ccc2Cl)cc1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
140.00 | IC50 | CHEMBL1083834 | ChEMBL ↗ |
|
146034 ↗ |
CCc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)C[C@H]3O)ccc2C)cc1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
2.00×103 | IC50 | CHEMBL1083835 | ChEMBL ↗ |
|
146035 ↗ |
OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(-c4nncs4)nn3)c2)[C@H](O)[C@@H](O)[C@@H]1O
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
11.40 | IC50 | CHEMBL1083975 | ChEMBL ↗ |
|
146036 ↗ |
OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(-c4ccoc4)nn3)c2)[C@H](O)[C@@H](O)[C@@H]1O
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
61.30 | IC50 | CHEMBL1083978 | ChEMBL ↗ |
|
146037 ↗ |
OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(-c4ccccc4)nn3)c2)[C@H](O)[C@@H](O)[C@@H]1O
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
222.00 | IC50 | CHEMBL1083979 | ChEMBL ↗ |
|
146038 ↗ |
OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(-c4ccc(F)cc4)nn3)c2)[C@H](O)[C@@H](O)[C@@H]1O
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
272.00 | IC50 | CHEMBL1083980 | ChEMBL ↗ |
|
146039 ↗ |
OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(-c4cccs4)nn3)c2)[C@H](O)[C@@H](O)[C@@H]1O
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
71.40 | IC50 | CHEMBL1084166 | ChEMBL ↗ |
|
146040 ↗ |
OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(-c4ccc5c(c4)OCO5)nn3)c2)[C@H](O)[C@@H](O)[C@@H]1O
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
82.70 | IC50 | CHEMBL1084258 | ChEMBL ↗ |
|
146041 ↗ |
OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(-c4ccc5c(c4)OCCO5)nn3)c2)[C@H](O)[C@@H](O)[C@@H]1O
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
103.00 | IC50 | CHEMBL1084259 | ChEMBL ↗ |
|
146042 ↗ |
OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(-c4ccsc4)nn3)c2)[C@H](O)[C@@H](O)[C@@H]1O
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
75.40 | IC50 | CHEMBL1084440 | ChEMBL ↗ |
|
146043 ↗ |
Cc1ccc(-c2ccc(Cc3cc([C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)ccc3Cl)nn2)s1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
168.00 | IC50 | CHEMBL1085015 | ChEMBL ↗ |
|
146044 ↗ |
CCc1ccc(Cc2cc(CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2C)cc1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
1.00×103 | IC50 | CHEMBL1085188 | ChEMBL ↗ |
|
146045 ↗ |
COc1cccc(-c2ccc(Cc3cc([C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)ccc3Cl)nn2)c1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
351.00 | IC50 | CHEMBL1085271 | ChEMBL ↗ |
|
146046 ↗ |
OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(-c4cccnc4)nn3)c2)[C@H](O)[C@@H](O)[C@@H]1O
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
64.90 | IC50 | CHEMBL1085272 | ChEMBL ↗ |
|
146047 ↗ |
Cc1cnc(-c2ccc(Cc3cc([C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)ccc3Cl)nn2)o1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
1.71×103 | IC50 | CHEMBL1085273 | ChEMBL ↗ |
|
146048 ↗ |
CCCOc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)nn1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
70.80 | IC50 | CHEMBL1085297 | ChEMBL ↗ |
|
146049 ↗ |
CCc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)ccc2C)cc1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
139.00 | IC50 | CHEMBL1085454 | ChEMBL ↗ |
|
146050 ↗ |
COc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](OC)[C@H](O)[C@H]3O)ccc2Cl)cc1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
180.00 | IC50 | CHEMBL1085455 | ChEMBL ↗ |
|
146051 ↗ |
CC(C)Cc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)nn1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
811.00 | IC50 | CHEMBL1085528 | ChEMBL ↗ |
|
146052 ↗ |
CCCCCc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)nn1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
134.00 | IC50 | CHEMBL1085529 | ChEMBL ↗ |
|
146053 ↗ |
CC(C)Oc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)nn1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
110.00 | IC50 | CHEMBL1085544 | ChEMBL ↗ |
|
146054 ↗ |
CCCCOc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)nn1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
109.00 | IC50 | CHEMBL1085545 | ChEMBL ↗ |
|
146055 ↗ |
CC(C)COc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)nn1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
435.00 | IC50 | CHEMBL1085546 | ChEMBL ↗ |
|
146056 ↗ |
CCCCCOc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)nn1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
17.00 | IC50 | CHEMBL1085547 | ChEMBL ↗ |
|
146057 ↗ |
COc1ccc(Cc2cc([C@@H]3O[C@H](C)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)cc1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
2.40 | IC50 | CHEMBL1085691 | ChEMBL ↗ |
|
146058 ↗ |
CCCCCCOc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)nn1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
17.30 | IC50 | CHEMBL1085769 | ChEMBL ↗ |
|
146059 ↗ |
OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(OC4CCCCC4)nn3)c2)[C@H](O)[C@@H](O)[C@@H]1O
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
111.00 | IC50 | CHEMBL1085770 | ChEMBL ↗ |
|
146060 ↗ |
CSc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)nn1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
13.40 | IC50 | CHEMBL1085771 | ChEMBL ↗ |
|
146061 ↗ |
OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(Sc4ccccc4)nn3)c2)[C@H](O)[C@@H](O)[C@@H]1O
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
1.87×103 | IC50 | CHEMBL1085772 | ChEMBL ↗ |
|
146062 ↗ |
CSc1nnc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)cc1C
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
1.52×103 | IC50 | CHEMBL1085844 | ChEMBL ↗ |
|
146063 ↗ |
CSc1nnc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)c(C)c1C
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
10.00×103 | IC50 | CHEMBL1085845 | ChEMBL ↗ |
|
146064 ↗ |
Cc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)nn1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
293.00 | IC50 | CHEMBL1086006 | ChEMBL ↗ |
|
146065 ↗ |
Cc1nnc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)c2ccccc12
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
10.00×103 | IC50 | CHEMBL1086076 | ChEMBL ↗ |
|
146066 ↗ |
OC[C@H]1O[C@@H](c2ccc(Cl)c(Cc3ccc(OC4CCOCC4)nn3)c2)[C@H](O)[C@@H](O)[C@@H]1O
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
77.60 | IC50 | CHEMBL1086192 | ChEMBL ↗ |
|
146067 ↗ |
CCc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2C)cc1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
1.50 | IC50 | CHEMBL1086408 | ChEMBL ↗ |
|
146068 ↗ |
CCSc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)nn1
|
CHEMBL3884 ↗
UniProt: P31639 ↗ |
71.30 | IC50 | CHEMBL1086441 | ChEMBL ↗ |