CHEMBL3952 Ki
BioactivityChEMBL CHEMBL3952 Ki bioactivity data
1489 compounds · Target: Kappa-type opioid receptor ( CHEMBL3952 ↗ ) · UniProt: P41144 ↗ · Ki
Kappa-type opioid receptor, a molecular target studied in Cavia porcellus.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
40784 ↗ |
Oc1cccc(CCN(CCc2ccccc2)CC2CCC2)c1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
1.91 | Ki | CHEMBL2180639 | ChEMBL ↗ |
|
60771 ↗ |
CNC(=O)Cn1c(=O)n(C2CCN([C@H]3CC[C@@H](C(C)C)CC3)CC2)c2ccccc21
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
2.70×103 | Ki | CHEMBL1080485 | ChEMBL ↗ |
|
60801 ↗ |
CCC(=O)N1C[C@H]2[C@H](N3CCCC3)CC[C@@H]1CN2C(=O)Cc1ccc(Cl)c(Cl)c1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
13.00 | Ki | CHEMBL1094237 | ChEMBL ↗ |
|
60802 ↗ |
COC(=O)N1C[C@H]2[C@H](N3CCCC3)CC[C@@H]1CN2C(=O)Cc1ccc(Cl)c(Cl)c1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
1.00 | Ki | CHEMBL1094880 | ChEMBL ↗ |
|
60804 ↗ |
O=C(Cc1ccc(Cl)c(Cl)c1)N1C[C@H]2CC[C@@H](N3CCCC3)[C@@H]1CN2Cc1ccccc1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
8.70 | Ki | CHEMBL1095521 | ChEMBL ↗ |
|
60805 ↗ |
O=C(Cc1ccc(Cl)c(Cl)c1)N1C[C@@H]2CC[C@@H](N3CCCC3)[C@H]1CN2Cc1ccccc1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
152.00 | Ki | CHEMBL1096473 | ChEMBL ↗ |
|
60806 ↗ |
O=C(Cc1ccc(Cl)c(Cl)c1)N1C[C@H]2CC[C@H](N3CCCC3)[C@@H]1CN2Cc1ccccc1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
421.00 | Ki | CHEMBL1096474 | ChEMBL ↗ |
|
60807 ↗ |
COC(=O)N1C[C@H]2[C@@H](N3CCCC3)CC[C@@H]1CN2C(=O)Cc1ccc(Cl)c(Cl)c1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
80.00 | Ki | CHEMBL1096475 | ChEMBL ↗ |
|
60811 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)[C@@H](O)C/C=C/[C@@H](O)[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
50.00 | Ki | CHEMBL1161412 | ChEMBL ↗ |
|
60812 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)[C@H](O)C/C=C/[C@H](O)[C@@H](Cc1ccccc1)C(=O)NCCc1ccccc1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
51.00 | Ki | CHEMBL1161413 | ChEMBL ↗ |
|
60813 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)[C@@H](O)C/C=C/[C@H](O)[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
22.00 | Ki | CHEMBL1161414 | ChEMBL ↗ |
|
60814 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)[C@H](O)C/C=C/[C@H](O)[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
15.00 | Ki | CHEMBL1161415 | ChEMBL ↗ |
|
60815 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)[C@@H](O)C/C=C/[C@@H](O)[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
21.00 | Ki | CHEMBL1161416 | ChEMBL ↗ |
|
60816 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)[C@H](O)C/C=C/[C@@H](O)[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
25.00 | Ki | CHEMBL1161417 | ChEMBL ↗ |
|
60817 ↗ |
NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)Cc1ccccc1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
10.40×103 | Ki | CHEMBL1161419 | ChEMBL ↗ |
|
60818 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)[C@H](O)C/C=C/[C@@H](O)[C@@H](Cc1ccccc1)C(=O)NCCc1ccccc1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
69.00 | Ki | CHEMBL1161422 | ChEMBL ↗ |
|
60819 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)[C@@H](O)C/C=C/[C@H](O)[C@@H](Cc1ccccc1)C(=O)O[C@H](CO)Cc1ccccc1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
85.00 | Ki | CHEMBL1161423 | ChEMBL ↗ |
|
60820 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)[C@@H](O)C/C=C/[C@H](O)[C@@H](Cc1ccccc1)C(=O)OCCc1ccccc1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
260.00 | Ki | CHEMBL1161424 | ChEMBL ↗ |
|
60821 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)[C@@H](O)C/C=C/[C@H](O)[C@@H](Cc1ccccc1)C(=O)O[C@@H](Cc1ccccc1)C(N)=O
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
126.00 | Ki | CHEMBL1161425 | ChEMBL ↗ |
|
60822 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)[C@@H](O)C/C=C/[C@H](O)[C@@H](Cc1ccccc1)C(=O)N[C@H](CO)Cc1ccccc1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
69.00 | Ki | CHEMBL1161427 | ChEMBL ↗ |
|
60823 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)[C@@H](O)C/C=C/[C@@H](O)[C@H](Cc1ccccc1)C(=O)NCCc1ccccc1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
60.00 | Ki | CHEMBL1161428 | ChEMBL ↗ |
|
60824 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)[C@@H](O)C/C=C/[C@@H](O)[C@@H](Cc1ccccc1)C(=O)NCCc1ccccc1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
64.00 | Ki | CHEMBL1161429 | ChEMBL ↗ |
|
60825 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)[C@@H](O)C/C=C/[C@H](O)[C@@H](Cc1ccccc1)C(=O)NCCc1ccccc1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
42.00 | Ki | CHEMBL1161430 | ChEMBL ↗ |
|
60827 ↗ |
C[N+]1(CC2CC2)CC[C@]23c4c5ccc(O)c4O[C@H]2C(=O)CC[C@@]3(O)[C@H]1C5
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
19.95 | Ki | CHEMBL1186579 | ChEMBL ↗ |
|
60834 ↗ |
C=CCN1C[C@H](C)N([C@H](c2ccc(C(=O)N(CC)CC)cc2)c2cccc(OC)c2)C[C@H]1C
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
10.23×103 | Ki | CHEMBL13470 | ChEMBL ↗ |
|
60835 ↗ |
CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)O
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
4.47×103 | Ki | CHEMBL13786 | ChEMBL ↗ |
|
60852 ↗ |
C[C@H]1C2Cc3cc4cc[nH]c4cc3[C@@]1(C)CCN2CC1CC1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
7.00 | Ki | CHEMBL170384 | ChEMBL ↗ |
|
60887 ↗ |
COC1Cc2ccccc2[C@]2(CC[C@@H](N(C)Cc3ccccc3)CC2)O1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
250.00 | Ki | CHEMBL1779999 | ChEMBL ↗ |
|
60888 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H]1Cc2ccccc2CN(CC(N)=O)C1=O
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
118.00 | Ki | CHEMBL1782140 | ChEMBL ↗ |
|
60891 ↗ |
C#CCN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(O)cc13
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
3.00×10-3 | Ki | CHEMBL1790045 | ChEMBL ↗ |
|
60892 ↗ |
O=C1CC[C@@]2(O)[C@H]3Cc4ccc(O)cc4[C@@]2(CCN3CC2CC2)C1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
38.00×10-3 | Ki | CHEMBL1797689 | ChEMBL ↗ |
|
61018 ↗ |
NC(=O)[C@@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
1.12 | Ki | CHEMBL1927270 | ChEMBL ↗ |
|
61183 ↗ |
COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(NC/C=C/c5ccc(Cl)cc5)[C@@H](C2)N(CC2CC2)CC[C@]314
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
53.60 | Ki | CHEMBL216251 | ChEMBL ↗ |
|
61199 ↗ |
CC[C@H](C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(N)=O
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
86.90×10-3 | Ki | CHEMBL216640 | ChEMBL ↗ |
|
61226 ↗ |
Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
22.30 | Ki | CHEMBL2181202 | ChEMBL ↗ |
|
61423 ↗ |
COC(=O)Cn1c(=O)n(C2CCN(CCC(Oc3cc(OC)ccc3C)C(C)C)CC2)c2ccccc21
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
671.00 | Ki | CHEMBL238637 | ChEMBL ↗ |
|
61458 ↗ |
COc1ccc(C)c(OC(CCN2CCC(n3c(=O)n(CCN(C)C)c4ccccc43)CC2)C(C)C)c1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
4.28×103 | Ki | CHEMBL238795 | ChEMBL ↗ |
|
61462 ↗ |
COCn1c(=O)n(C2CCN(CCC(Oc3cc(OC)ccc3C)C(C)C)CC2)c2ccccc21
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
124.50 | Ki | CHEMBL238833 | ChEMBL ↗ |
|
61463 ↗ |
COCCn1c(=O)n(C2CCN(CCC(Oc3cc(OC)ccc3C)C(C)C)CC2)c2ccccc21
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
447.50 | Ki | CHEMBL239043 | ChEMBL ↗ |
|
61465 ↗ |
CCC(=O)Cn1c(=O)n(C2CCN(CCC(Oc3cc(OC)ccc3C)C(C)C)CC2)c2ccccc21
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
1.55×103 | Ki | CHEMBL239260 | ChEMBL ↗ |
|
61466 ↗ |
CC[C@@H]1CN2CC[C@@]34OCCO[C@@]3(Nc3ccc(F)c(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
18.00 | Ki | CHEMBL2396991 | ChEMBL ↗ |
|
61483 ↗ |
COc1ccc(C)c(OC(CCN2CCC(n3c(=O)n(CSC)c4ccccc43)CC2)C(C)C)c1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
99.00 | Ki | CHEMBL240074 | ChEMBL ↗ |
|
61484 ↗ |
CNCCn1c(=O)n(C2CCN(CCC(Oc3cc(OC)ccc3C)C(C)C)CC2)c2ccccc21
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
4.21×103 | Ki | CHEMBL240084 | ChEMBL ↗ |
|
61508 ↗ |
COc1ccc(C)c(OC(CCN2CCC(n3c(=O)n(CS(C)(=O)=O)c4ccccc43)CC2)C(C)C)c1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
374.00 | Ki | CHEMBL241357 | ChEMBL ↗ |
|
61553 ↗ |
O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)[C@H]1O5
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
48.00 | Ki | CHEMBL252172 | ChEMBL ↗ |
|
61613 ↗ |
CN(C(=O)/C=C/c1ccoc1)[C@@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)[C@H]1O5
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
175.00×10-3 | Ki | CHEMBL267495 | ChEMBL ↗ |
|
61616 ↗ |
C[C@H]1CN(C[C@H](Cc2ccccc2)C(=O)NCC(=O)O)CC[C@@]1(C)c1cccc(O)c1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
5.01 | Ki | CHEMBL270190 | ChEMBL ↗ |
|
61642 ↗ |
COC(=O)N1CCN(C(=O)Cc2ccc(Cl)c(Cl)c2)[C@H](CN2CCCC2)C1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
450.00×10-3 | Ki | CHEMBL277863 | ChEMBL ↗ |
|
61647 ↗ |
CC1C2Cc3ccc(O)cc3C1(C)CCN2CC1CC1
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
180.00×10-3 | Ki | CHEMBL289683 | ChEMBL ↗ |
|
61648 ↗ |
CC[C@@H]1CN2CCc3c([nH]c4cccc(O)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC
|
CHEMBL3952 ↗
UniProt: P41144 ↗ |
2.95×103 | Ki | CHEMBL292521 | ChEMBL ↗ |