CHEMBL4005 IC50
BioactivityChEMBL CHEMBL4005 IC50 bioactivity data
3510 compounds · Target: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform ( CHEMBL4005 ↗ ) · UniProt: P42336 ↗ · IC50
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
1821 ↗ |
O=c1cc(N2CCOCC2)oc2c(-c3cccc4c3sc3ccccc34)cccc12
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
130.00 | IC50 | CHEMBL188678 | ChEMBL ↗ |
|
2382 ↗ |
CCC(=O)N1CCN(S(=O)(=O)c2cccc(Nc3ncc4c(n3)N(C)c3ccc(C)cc3C(=O)N4C)c2)CC1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
70.00 | IC50 | CHEMBL3942643 | ChEMBL ↗ |
|
2384 ↗ |
Cc1ccc2c(c1)C(=O)N(C)c1cnc(Nc3cccc(S(=O)(=O)N4CCC(O)CC4)c3)nc1N2C
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
55.00 | IC50 | CHEMBL3959351 | ChEMBL ↗ |
|
2394 ↗ |
C=CC(=O)N1CCN(S(=O)(=O)c2cccc(Nc3ncc4c(n3)N(C)c3ccc(C)cc3C(=O)N4C)c2)CC1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
53.00 | IC50 | CHEMBL3979343 | ChEMBL ↗ |
|
6654 ↗ |
Cn1cc(CNCC2CCN(c3ncc(C(=O)NO)cn3)CC2)c2ccccc21
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
19.00 | IC50 | CHEMBL2105763 | ChEMBL ↗ |
|
7350 ↗ |
CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(NCc3ccc(C(=O)NO)cn3)c2c(=O)n1-c1ccccc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
392.00 | IC50 | CHEMBL4443548 | ChEMBL ↗ |
|
7361 ↗ |
CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(CCCCCC(=O)NO)c2c(=O)n1-c1ccccc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
122.00 | IC50 | CHEMBL4451623 | ChEMBL ↗ |
|
9147 ↗ |
CC[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(CCCCCC(=O)NO)c2c(=O)n1-c1ccccc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
9.00 | IC50 | CHEMBL4443378 | ChEMBL ↗ |
|
9171 ↗ |
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CCc3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
13.00 | IC50 | CHEMBL4450613 | ChEMBL ↗ |
|
9183 ↗ |
CC[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(NCc3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
47.00 | IC50 | CHEMBL4455923 | ChEMBL ↗ |
|
9200 ↗ |
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(NCc3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
42.00 | IC50 | CHEMBL4460447 | ChEMBL ↗ |
|
9210 ↗ |
COc1ccc(-c2cc(OCCN(C)c3ncc(C(=O)NO)cn3)c3ncnc(C)c3c2)cn1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
226.00 | IC50 | CHEMBL4462577 | ChEMBL ↗ |
|
9213 ↗ |
CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(CNC(=O)c3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
266.00 | IC50 | CHEMBL4464003 | ChEMBL ↗ |
|
9215 ↗ |
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(NCc3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
50.00 | IC50 | CHEMBL4464812 | ChEMBL ↗ |
|
9275 ↗ |
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CNC(=O)c3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
18.00 | IC50 | CHEMBL4522666 | ChEMBL ↗ |
|
9282 ↗ |
Cc1nc(N)nc(N[C@@H](C)c2nc3cccc(NCc4ccc(C(=O)NO)cc4)c3c(=O)n2-c2ccccc2)c1C#N
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
75.00 | IC50 | CHEMBL4526673 | ChEMBL ↗ |
|
9302 ↗ |
COc1ncc(-c2cc(OCCCCCCC(=O)NO)c3ncnc(C)c3c2)cc1F
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
42.00 | IC50 | CHEMBL4536105 | ChEMBL ↗ |
|
9314 ↗ |
CC[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(NCCCCC(=O)NO)c2c(=O)n1-c1ccccc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
186.00 | IC50 | CHEMBL4544187 | ChEMBL ↗ |
|
9330 ↗ |
CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CCCCCC(=O)NO)c2c(=O)n1-c1ccccc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
52.00 | IC50 | CHEMBL4550648 | ChEMBL ↗ |
|
9381 ↗ |
CC[C@H](Nc1ncnc(N)c1C#N)c1nc2cccc(NCc3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
444.00 | IC50 | CHEMBL4578757 | ChEMBL ↗ |
|
9389 ↗ |
CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(CNc3ncc(C(=O)NO)cn3)c2c(=O)n1-c1ccccc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
422.00 | IC50 | CHEMBL4581057 | ChEMBL ↗ |
|
9393 ↗ |
C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CNc3ncc(C(=O)NO)cn3)c2c(=O)n1-c1ccccc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
42.00 | IC50 | CHEMBL4583074 | ChEMBL ↗ |
|
9399 ↗ |
CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(NCc3ccc(C(=O)NO)c(C)c3)c2c(=O)n1-c1ccccc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
517.00 | IC50 | CHEMBL4586038 | ChEMBL ↗ |
|
9467 ↗ |
Nc1ncc(-c2nc(N3CCOCC3)c3ccn(CCCCCCC(=O)NO)c3n2)cn1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
11.00 | IC50 | CHEMBL4744689 | ChEMBL ↗ |
|
9481 ↗ |
O=C(CCCCCCn1cnc2c(N3CCOCC3)nc(-c3cccc(CO)c3)nc21)NO
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
28.00 | IC50 | CHEMBL4749655 | ChEMBL ↗ |
|
9562 ↗ |
Nc1ccc(-c2nc(N3CCOCC3)c3ncn(CCCCCCC(=O)NO)c3n2)cn1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
198.00 | IC50 | CHEMBL4785064 | ChEMBL ↗ |
|
9989 ↗ |
O=C(NO)c1ccc(Cn2cc(-c3cccc(O)c3)nc(N3CCOCC3)c2=O)cc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
467.00 | IC50 | CHEMBL5170590 | ChEMBL ↗ |
|
10039 ↗ |
Nc1ncc(-c2cn(Cc3ccc(C(=O)NO)cc3)c(=O)c(N3CCOCC3)n2)cn1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
197.00 | IC50 | CHEMBL5179687 | ChEMBL ↗ |
|
10046 ↗ |
O=C(NO)c1ccc(Cn2cc(-c3cccc4[nH]ncc34)nc(N3CCOCC3)c2=O)cc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
373.00 | IC50 | CHEMBL5180796 | ChEMBL ↗ |
|
10057 ↗ |
O=C(NO)c1ccc(/C=N/NC(=O)c2cc(N3CCOCC3)nc(-c3cccc4[nH]ncc34)n2)cc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
8.34 | IC50 | CHEMBL5182686 | ChEMBL ↗ |
|
10063 ↗ |
Nc1ncc(-c2cn(CCCCCC(=O)NO)c(=O)c(N3CCOCC3)n2)cn1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
157.00 | IC50 | CHEMBL5183646 | ChEMBL ↗ |
|
10074 ↗ |
Nc1ncc(-c2cn(CCCCCCCC(=O)NO)c(=O)c(N3CCOCC3)n2)cn1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
278.00 | IC50 | CHEMBL5185319 | ChEMBL ↗ |
|
10082 ↗ |
Nc1ncc(-c2cn(CCCCCCC(=O)NO)c(=O)c(N3CCOCC3)n2)cn1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
127.00 | IC50 | CHEMBL5187051 | ChEMBL ↗ |
|
10121 ↗ |
O=C(NO)c1ccc(/C=N/NC(=O)c2cc(N3CCOCC3)nc(-c3cccc(O)c3)n2)cc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
46.30 | IC50 | CHEMBL5192518 | ChEMBL ↗ |
|
10169 ↗ |
CNc1ncc(-c2cn(Cc3ccc(C(=O)NO)cc3)c(=O)c(N3CCOCC3)n2)cn1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
336.00 | IC50 | CHEMBL5202725 | ChEMBL ↗ |
|
10208 ↗ |
N#Cc1c(N)nc(N)nc1N1CC2(CC2)C[C@H]1c1nc2cccc(Cl)c2c(=O)n1Cc1ccc(C(=O)NO)s1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
168.90 | IC50 | CHEMBL5218472 | ChEMBL ↗ |
|
14315 ↗ |
Oc1ccc(/C=C/c2cc(O)cc(O)c2)cc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
250.00 | IC50 | CHEMBL165 | ChEMBL ↗ |
|
16114 ↗ |
O=C1NC(=O)/C(=C/c2ccc3nccnc3c2)S1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
60.00 | IC50 | CHEMBL568150 | ChEMBL ↗ |
|
17017 ↗ |
Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
1.40×103 | IC50 | CHEMBL3787112 | ChEMBL ↗ |
|
18034 ↗ |
CCN(CC)CCCNc1nc(-c2ccc(NC(=O)Nc3ccc(Cl)cc3)cc2)nc2ccsc12
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
130.00 | IC50 | CHEMBL3326099 | ChEMBL ↗ |
|
18060 ↗ |
Cc1cc(/C=N/NC(=O)Nc2ccc(-c3nc(N4CCOCC4)c4sccc4n3)cc2)cc(C)c1O
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
27.00 | IC50 | CHEMBL3343621 | ChEMBL ↗ |
|
18134 ↗ |
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnn2ccc(Cl)nc12
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
271.00 | IC50 | CHEMBL3612482 | ChEMBL ↗ |
|
18136 ↗ |
CN(/N=C/c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cccc([N+](=O)[O-])c1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
4.35×103 | IC50 | CHEMBL3612485 | ChEMBL ↗ |
|
18139 ↗ |
CN(/N=C/c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cccc(F)c1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
4.54×103 | IC50 | CHEMBL3612490 | ChEMBL ↗ |
|
18144 ↗ |
Cc1ccc(C#N)cc1S(=O)(=O)N(C)/N=C/c1cnn2ccc(Cl)nc12
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
2.96×103 | IC50 | CHEMBL3612498 | ChEMBL ↗ |
|
18145 ↗ |
Cc1ccc(S(C)(=O)=O)cc1S(=O)(=O)N(C)/N=C/c1cnn2ccc(Cl)nc12
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
9.43×103 | IC50 | CHEMBL3612500 | ChEMBL ↗ |
|
18146 ↗ |
CN(/N=C/c1cnn2ccc(Cl)nc12)S(=O)(=O)c1cc([N+](=O)[O-])ccc1Cl
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
29.00 | IC50 | CHEMBL3612501 | ChEMBL ↗ |
|
18147 ↗ |
COc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnn2ccc(Cl)nc12
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
81.00 | IC50 | CHEMBL3612502 | ChEMBL ↗ |
|
18148 ↗ |
Cc1ccn2ncc(/C=N/N(C)S(=O)(=O)c3cc([N+](=O)[O-])ccc3C)c2n1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
902.00 | IC50 | CHEMBL3612503 | ChEMBL ↗ |
|
18149 ↗ |
COc1ccc(-c2ccn3ncc(/C=N/N(C)S(=O)(=O)c4cc([N+](=O)[O-])ccc4C)c3n2)cc1OC
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
233.00 | IC50 | CHEMBL3612504 | ChEMBL ↗ |