CHEMBL4005 Ki
BioactivityChEMBL CHEMBL4005 Ki bioactivity data
1018 compounds · Target: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform ( CHEMBL4005 ↗ ) · UniProt: P42336 ↗ · Ki
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
4153 ↗ |
O=c1cc(N2CCOCC2)oc2c(-c3ccccc3)cccc12
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
6.00×103 | Ki | CHEMBL98350 | ChEMBL ↗ |
|
71458 ↗ |
Cc1nc(NC(=O)NCCc2cn(CC(F)F)cn2)sc1C#Cc1cccnc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
252.00 | Ki | CHEMBL4795990 | ChEMBL ↗ |
|
112162 ↗ |
COc1ccc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCCO)CC3)c2=O)cn1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
1.80 | Ki | CHEMBL1234354 | ChEMBL ↗ |
|
112163 ↗ |
COc1ncc(-c2ccc3nccc(-c4ccnnc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
19.00×10-3 | Ki | CHEMBL1236962 | ChEMBL ↗ |
|
112199 ↗ |
N#CCNc1ncnc(-n2c(Nc3cccc(O)c3)nc3ccccc32)n1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
350.00 | Ki | CHEMBL1615182 | ChEMBL ↗ |
|
112261 ↗ |
CCNC(=O)Nc1ccc(-c2nc3c(c(N4C[C@H]5CC[C@@H](C4)O5)n2)CS(=O)(=O)CC3)cc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
3.00×103 | Ki | CHEMBL2063759 | ChEMBL ↗ |
|
112265 ↗ |
COc1ccc(Nc2ncc(CN3CCC(S(C)(=O)=O)C3)cc2-c2nc(C)nc(N)n2)cn1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
16.00 | Ki | CHEMBL2165004 | ChEMBL ↗ |
|
112266 ↗ |
COc1ccc(Nc2ncc(CN3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cn1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
9.00 | Ki | CHEMBL2165017 | ChEMBL ↗ |
|
112267 ↗ |
COc1ccc(Nc2ncc(CO)cc2-c2nc(C)nc(N)n2)cn1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
63.00 | Ki | CHEMBL2165026 | ChEMBL ↗ |
|
112268 ↗ |
Cc1nc(-c2cccnc2Nc2cccc3n[nH]cc23)c2[nH]cnc2n1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
37.50 | Ki | CHEMBL2165037 | ChEMBL ↗ |
|
112269 ↗ |
Cc1nc(-c2cccnc2Nc2cccc3[nH]ccc23)c2[nH]cnc2n1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
185.50 | Ki | CHEMBL2165038 | ChEMBL ↗ |
|
112270 ↗ |
COc1ccc(Nc2ncccc2-c2nc(C)nc3nc[nH]c23)cn1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
64.50 | Ki | CHEMBL2165039 | ChEMBL ↗ |
|
112271 ↗ |
COc1ccc(Nc2ncccc2-c2ncnc3nc[nH]c23)cn1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
7.79×103 | Ki | CHEMBL2165041 | ChEMBL ↗ |
|
112272 ↗ |
Cc1nc(N)nc(-c2cccnc2Nc2cccc(O)c2)n1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
12.50 | Ki | CHEMBL2165052 | ChEMBL ↗ |
|
112273 ↗ |
Cc1nc(N)nc(-c2cccnc2Nc2cccc3[nH]ccc23)n1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
193.50 | Ki | CHEMBL2165268 | ChEMBL ↗ |
|
112274 ↗ |
COc1ccc(Nc2ncccc2-c2nc(C)nc(N)n2)cn1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
108.50 | Ki | CHEMBL2165269 | ChEMBL ↗ |
|
112275 ↗ |
Cc1nc(N)cc(-c2cccnc2Nc2cccc(O)c2)n1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
26.00 | Ki | CHEMBL2165270 | ChEMBL ↗ |
|
112276 ↗ |
COc1ncc(Nc2ncc([C@@H](C)N3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cc1F
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
4.00 | Ki | CHEMBL2170081 | ChEMBL ↗ |
|
112277 ↗ |
COc1ncc(Nc2ncc(CN3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cn1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
8.00 | Ki | CHEMBL2170095 | ChEMBL ↗ |
|
112279 ↗ |
COc1cnc(Nc2cnc(Cl)c(NS(C)(=O)=O)c2)c(-c2nc(C)nc(N)n2)c1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
9.00 | Ki | CHEMBL2206903 | ChEMBL ↗ |
|
112280 ↗ |
COc1cnc(Nc2cnc(Cl)c(NS(=O)(=O)N(C)C)c2)c(-c2nc(C)nc(N)n2)c1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
11.65 | Ki | CHEMBL2206904 | ChEMBL ↗ |
|
112281 ↗ |
COc1cnc(Nc2cnc(Cl)c(NS(=O)(=O)N3CCOCC3)c2)c(-c2nc(C)nc(N)n2)c1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
12.00 | Ki | CHEMBL2206905 | ChEMBL ↗ |
|
112283 ↗ |
Cc1nc(N)nc(-c2cc(C3CCOCC3)cnc2Nc2cnc(Cl)c(NS(C)(=O)=O)c2)n1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
2.00 | Ki | CHEMBL2206907 | ChEMBL ↗ |
|
112284 ↗ |
Cc1nc(N)nc(-c2cc(CN3CCOCC3)cnc2Nc2cnc(Cl)c(NS(C)(=O)=O)c2)n1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
6.85 | Ki | CHEMBL2206908 | ChEMBL ↗ |
|
112285 ↗ |
Cc1nc(N)nc(-c2cccnc2Nc2cnc(Cl)c(N)c2)n1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
342.00 | Ki | CHEMBL2206911 | ChEMBL ↗ |
|
112287 ↗ |
Cc1nc(N)nc(-c2cccnc2Nc2cnc(Cl)c(NS(=O)(=O)C3CC3)c2)n1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
8.50 | Ki | CHEMBL2206914 | ChEMBL ↗ |
|
112288 ↗ |
Cc1nc(N)nc(-c2cccnc2Nc2cnc(Cl)c(NS(=O)(=O)N(C)C(C)C)c2)n1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
43.50 | Ki | CHEMBL2206916 | ChEMBL ↗ |
|
112289 ↗ |
Cc1nc(N)nc(-c2cccnc2Nc2cnc(Cl)c(NS(=O)(=O)N3CCOCC3)c2)n1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
15.00 | Ki | CHEMBL2206917 | ChEMBL ↗ |
|
112308 ↗ |
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3CC)c3c(cnn3C)n2)cc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
3.40×103 | Ki | CHEMBL2418349 | ChEMBL ↗ |
|
112309 ↗ |
CCNC(=O)Nc1ccc(-c2nc(N3CCOC[C@@H]3CC)c3c(n2)c(C)nn3C)cc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
5.80×103 | Ki | CHEMBL2418350 | ChEMBL ↗ |
|
112310 ↗ |
CCNC(=O)Nc1ccc(-c2nc(N3C[C@@H]4C[C@H]3CO4)c3c(cnn3C)n2)cc1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
5.13×103 | Ki | CHEMBL2418351 | ChEMBL ↗ |
|
112375 ↗ |
COc1ncc(Nc2ncc(C(O)C(F)(F)F)cc2-c2nc(C)nc(N)n2)cc1F
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
17.00 | Ki | CHEMBL3357867 | ChEMBL ↗ |
|
112376 ↗ |
COc1ncc(Nc2ncc(C(C)(C)O)cc2-c2nc(C)nc(N)n2)cc1F
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
4.00 | Ki | CHEMBL3357868 | ChEMBL ↗ |
|
112379 ↗ |
Cc1nc(N)nc(-c2cc(C(C)(C)O)cnc2Nc2cncc(F)c2)n1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
23.00 | Ki | CHEMBL3357874 | ChEMBL ↗ |
|
112380 ↗ |
COc1ncc(Nc2ncc(C(C)(C)O)cc2-c2nc(C)nc(N)n2)cc1C
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
12.00 | Ki | CHEMBL3357875 | ChEMBL ↗ |
|
112382 ↗ |
Cc1nc(N)nc(-c2cc(C(C)(C)O)cnc2Nc2cncc(S(=O)(=O)c3ccccc3)c2)n1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
58.00 | Ki | CHEMBL3358286 | ChEMBL ↗ |
|
112383 ↗ |
COc1cc(Nc2ncc(C(C)(C)O)cc2-c2nc(C)nc(N)n2)cnc1OC
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
19.00 | Ki | CHEMBL3358287 | ChEMBL ↗ |
|
112384 ↗ |
COc1cncc(Nc2ncc(C(C)(C)O)cc2-c2nc(C)nc(N)n2)c1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
15.00 | Ki | CHEMBL3358288 | ChEMBL ↗ |
|
112400 ↗ |
CC(C)n1nc(-c2ccc3oc(N)nc3c2)c2c(N)ncnc21
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
28.00 | Ki | CHEMBL3545097 | ChEMBL ↗ |
|
112461 ↗ |
COc1ccc(Nc2nc3ccccn3c2-c2nc(C)nc(N)n2)cn1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
29.00 | Ki | CHEMBL3618231 | ChEMBL ↗ |
|
112462 ↗ |
CCOc1ccc(Nc2nc3ccccn3c2-c2nc(C)nc(N)n2)cn1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
148.00 | Ki | CHEMBL3618232 | ChEMBL ↗ |
|
112463 ↗ |
COc1ncc(Nc2nc3ccccn3c2-c2nc(C)nc(N)n2)cc1F
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
14.00 | Ki | CHEMBL3618233 | ChEMBL ↗ |
|
112464 ↗ |
Cc1nc(N)nc(-c2c(Nc3ccc4ncccc4c3)nc3ccccn23)n1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
529.00 | Ki | CHEMBL3618234 | ChEMBL ↗ |
|
112465 ↗ |
Cc1nc(N)nc(-c2c(Nc3ccc4ccncc4c3)nc3ccccn23)n1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
54.00 | Ki | CHEMBL3618235 | ChEMBL ↗ |
|
112466 ↗ |
Cc1nc(N)nc(-c2c(Nc3ccc4cccnc4c3)nc3ccccn23)n1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
43.00 | Ki | CHEMBL3618236 | ChEMBL ↗ |
|
112467 ↗ |
Cc1nc(N)nc(-c2c(Nc3cccc4[nH]ncc34)nc3ccccn23)n1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
5.60 | Ki | CHEMBL3618237 | ChEMBL ↗ |
|
112468 ↗ |
COc1ncc(Nc2nc3ccc(N4CCNCC4)cn3c2-c2nc(C)nc(N)n2)cc1F
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
5.70 | Ki | CHEMBL3618238 | ChEMBL ↗ |
|
112469 ↗ |
COc1ccc(Nc2nc3ccc(N4CCNCC4)cn3c2-c2nc(C)nc(N)n2)cn1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
43.00 | Ki | CHEMBL3618239 | ChEMBL ↗ |
|
112470 ↗ |
COc1ncc(Nc2nc3ccc(N4CCN(C(C)C)CC4)cn3c2-c2nc(C)nc(N)n2)cc1F
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
6.50 | Ki | CHEMBL3618240 | ChEMBL ↗ |
|
112471 ↗ |
COCCN1CCN(c2ccc3nc(Nc4cnc(OC)c(F)c4)c(-c4nc(C)nc(N)n4)n3c2)CC1
|
CHEMBL4005 ↗
UniProt: P42336 ↗ |
6.30 | Ki | CHEMBL3618241 | ChEMBL ↗ |