CHEMBL4015 IC50
BioactivityChEMBL CHEMBL4015 IC50 bioactivity data
1140 compounds · Target: C-C chemokine receptor type 2 ( CHEMBL4015 ↗ ) · UniProt: P41597 ↗ · IC50
C-C chemokine receptor type 2, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
66296 ↗ |
CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
750.00×10-3 | IC50 | CHEMBL1091605 | ChEMBL ↗ |
|
66326 ↗ |
Cc1ccc(S(=O)(=O)C[C@@H]2C[C@H](N(C)C(C)C)CC[C@@H]2N2CC[C@H](NC(=O)c3cccc(C(F)(F)F)c3)C2=O)cc1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
400.00×10-3 | IC50 | CHEMBL1092678 | ChEMBL ↗ |
|
66327 ↗ |
CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
3.50 | IC50 | CHEMBL1092748 | ChEMBL ↗ |
|
66331 ↗ |
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)N[C@@H]1CCN(CCC2CCN(C(=O)c3cc(F)ccc3F)CC2)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
1.41×103 | IC50 | CHEMBL1092921 | ChEMBL ↗ |
|
66332 ↗ |
CC(C)N(C)[C@@H]1CC[C@H](N2CC[C@H](NC(=O)c3cc(F)cc(C(F)(F)F)c3)C2=O)[C@H](CS(=O)(=O)c2ccccc2)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
800.00×10-3 | IC50 | CHEMBL1092941 | ChEMBL ↗ |
|
66550 ↗ |
CCO[C@H]1CN([C@H]2CC[C@@](O)(c3ccccc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
2.30 | IC50 | CHEMBL1289083 | ChEMBL ↗ |
|
66555 ↗ |
CCO[C@H]1CN([C@H]2CC[C@@](O)(c3ccc(C)cc3)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
2.30 | IC50 | CHEMBL1289203 | ChEMBL ↗ |
|
66562 ↗ |
CCO[C@H]1CN([C@H]2CC[C@@](O)(c3ccc4c(c3)OCO4)CC2)C[C@@H]1NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
5.10 | IC50 | CHEMBL1289316 | ChEMBL ↗ |
|
66697 ↗ |
CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
3.45 | IC50 | CHEMBL1683074 | ChEMBL ↗ |
|
66698 ↗ |
CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3nccc(C(F)(F)F)n3)CC2)(C(C)C)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
9.75 | IC50 | CHEMBL1683075 | ChEMBL ↗ |
|
66790 ↗ |
CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](NC2C3CCCC2COC3)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
9.25 | IC50 | CHEMBL1782376 | ChEMBL ↗ |
|
66791 ↗ |
CO[C@@H]1COCC[C@@H]1N(C)[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
4.50 | IC50 | CHEMBL1782377 | ChEMBL ↗ |
|
66792 ↗ |
CO[C@@H]1COCC[C@@H]1N(C)[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)cnn3)CC2)(C(C)C)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
31.90 | IC50 | CHEMBL1782378 | ChEMBL ↗ |
|
66793 ↗ |
CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cncc(C(F)(F)F)c3)CC2)(C(C)C)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
15.60 | IC50 | CHEMBL1782566 | ChEMBL ↗ |
|
66794 ↗ |
CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cncc(C(F)(F)F)n3)CC2)(C(C)C)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
15.80 | IC50 | CHEMBL1782568 | ChEMBL ↗ |
|
66795 ↗ |
CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3ccnc(C(F)(F)F)n3)CC2)(C(C)C)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
25.60 | IC50 | CHEMBL1782569 | ChEMBL ↗ |
|
66796 ↗ |
CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ncn3)CC2)(C(C)C)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
17.80 | IC50 | CHEMBL1782570 | ChEMBL ↗ |
|
66797 ↗ |
CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3nncc(C(F)(F)F)n3)CC2)(C(C)C)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
29.10 | IC50 | CHEMBL1782571 | ChEMBL ↗ |
|
66798 ↗ |
CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)cnn3)CC2)(C(C)C)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
8.10 | IC50 | CHEMBL1782572 | ChEMBL ↗ |
|
66799 ↗ |
CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3nc(C(F)(F)F)cs3)CC2)(C(C)C)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
28.00 | IC50 | CHEMBL1782574 | ChEMBL ↗ |
|
66800 ↗ |
CCO[C@H]1COCC[C@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
20.90 | IC50 | CHEMBL1782576 | ChEMBL ↗ |
|
66801 ↗ |
CCO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
15.50 | IC50 | CHEMBL1782577 | ChEMBL ↗ |
|
66802 ↗ |
CCC1COCC[C@@H]1N[C@@H]1CC[C@@](C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)(C(C)C)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
9.20 | IC50 | CHEMBL1782578 | ChEMBL ↗ |
|
66803 ↗ |
CC(C)[C@]1(C(=O)N2CCN(c3cc(C(F)(F)F)ccn3)CC2)CC[C@@H](N[C@H]2CCOC[C@H]2O)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
15.40 | IC50 | CHEMBL1782580 | ChEMBL ↗ |
|
66972 ↗ |
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@](O)(c3cccnc3)CC2)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
190.00 | IC50 | CHEMBL1829603 | ChEMBL ↗ |
|
66974 ↗ |
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@@H](c3ccc4c(c3)OCO4)CC2)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
5.00 | IC50 | CHEMBL1829605 | ChEMBL ↗ |
|
66975 ↗ |
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccccc3)CC2)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
35.00 | IC50 | CHEMBL1829609 | ChEMBL ↗ |
|
66976 ↗ |
O=C(CNC(=O)c1ccccc1)NC1CN([C@H]2CC[C@H](c3ccc4c(c3)OCO4)CC2)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
390.00 | IC50 | CHEMBL1829610 | ChEMBL ↗ |
|
66977 ↗ |
O=C(CNC(=O)c1ccc(C(F)(F)F)cc1)NC1CN([C@H]2CC[C@H](c3ccc4c(c3)OCO4)CC2)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
1.20×103 | IC50 | CHEMBL1829611 | ChEMBL ↗ |
|
66978 ↗ |
COc1ccc([C@H]2CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
10.00 | IC50 | CHEMBL1829612 | ChEMBL ↗ |
|
66979 ↗ |
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccc(O)cc3)CC2)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
21.00 | IC50 | CHEMBL1829613 | ChEMBL ↗ |
|
66980 ↗ |
COC(=O)c1ccc([C@H]2CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
80.00 | IC50 | CHEMBL1829614 | ChEMBL ↗ |
|
66981 ↗ |
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccc(C(=O)O)cc3)CC2)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
70.00 | IC50 | CHEMBL1829615 | ChEMBL ↗ |
|
66982 ↗ |
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccc(N4CCCC4)cc3)CC2)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
61.00 | IC50 | CHEMBL1829616 | ChEMBL ↗ |
|
66983 ↗ |
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccc4[nH]cnc4c3)CC2)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
27.00 | IC50 | CHEMBL1829617 | ChEMBL ↗ |
|
66984 ↗ |
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3cccnc3)CC2)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
45.00 | IC50 | CHEMBL1829618 | ChEMBL ↗ |
|
66985 ↗ |
COc1ccc([C@H]2CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
7.00 | IC50 | CHEMBL1829619 | ChEMBL ↗ |
|
66986 ↗ |
COc1cnccc1[C@H]1CC[C@H](N2CC(NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)CC1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
32.00 | IC50 | CHEMBL1829620 | ChEMBL ↗ |
|
66987 ↗ |
COc1cc([C@H]2CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)ccn1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
25.00 | IC50 | CHEMBL1829621 | ChEMBL ↗ |
|
66988 ↗ |
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3cnccn3)CC2)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
44.00 | IC50 | CHEMBL1829622 | ChEMBL ↗ |
|
66989 ↗ |
CN(C)c1ncc([C@H]2CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cn1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
31.00 | IC50 | CHEMBL1829623 | ChEMBL ↗ |
|
66990 ↗ |
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccc(O)cn3)CC2)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
13.00 | IC50 | CHEMBL1829624 | ChEMBL ↗ |
|
66991 ↗ |
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@H](c3ccncc3O)CC2)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
52.00 | IC50 | CHEMBL1829625 | ChEMBL ↗ |
|
66992 ↗ |
Nc1cccnc1[C@H]1CC[C@H](N2CC(NC(=O)CNC(=O)c3cccc(C(F)(F)F)c3)C2)CC1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
43.00 | IC50 | CHEMBL1829626 | ChEMBL ↗ |
|
66993 ↗ |
Nc1ccc([C@H]2CC[C@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)nc1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
85.00 | IC50 | CHEMBL1829627 | ChEMBL ↗ |
|
66994 ↗ |
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@](O)(c3ccccc3)CC2)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
36.00 | IC50 | CHEMBL1829628 | ChEMBL ↗ |
|
66995 ↗ |
O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CN([C@H]2CC[C@](O)(c3ccc(F)cc3)CC2)C1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
210.00 | IC50 | CHEMBL1829629 | ChEMBL ↗ |
|
66996 ↗ |
N#Cc1cccc([C@]2(O)CC[C@@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)c1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
410.00 | IC50 | CHEMBL1829630 | ChEMBL ↗ |
|
66997 ↗ |
CN(C)c1cccc([C@]2(O)CC[C@@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)c1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
15.00 | IC50 | CHEMBL1829631 | ChEMBL ↗ |
|
66998 ↗ |
COc1ccc([C@]2(O)CC[C@@H](N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)cc1
|
CHEMBL4015 ↗
UniProt: P41597 ↗ |
20.00 | IC50 | CHEMBL1829632 | ChEMBL ↗ |