CHEMBL4040 IC50
BioactivityChEMBL CHEMBL4040 IC50 bioactivity data
1129 compounds · Target: Mitogen-activated protein kinase 1 ( CHEMBL4040 ↗ ) · UniProt: P28482 ↗ · IC50
Mitogen-activated protein kinase 1, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
5372 ↗ |
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
109.50 | IC50 | CHEMBL1336 | ChEMBL ↗ |
|
5928 ↗ |
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
1.83×103 | IC50 | CHEMBL3884319 | ChEMBL ↗ |
|
6245 ↗ |
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(Cl)ccc3O)cc12
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
960.20 | IC50 | CHEMBL4105329 | ChEMBL ↗ |
|
6294 ↗ |
CN(CCc1ccc(-c2ccccc2)cc1)Cc1cn(C)c2ccc(C(=O)Nc3ccc(F)cc3)cc12
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
66.00×103 | IC50 | CHEMBL4446681 | ChEMBL ↗ |
|
6315 ↗ |
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
230.00 | IC50 | CHEMBL4568087 | ChEMBL ↗ |
|
6316 ↗ |
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
12.00×103 | IC50 | CHEMBL4569508 | ChEMBL ↗ |
|
16166 ↗ |
COc1cc(N2CCC(O)CC2)ccc1Nc1cc(Nc2ccccc2S(=O)(=O)C(C)C)c2cc[nH]c2n1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
2.90×103 | IC50 | CHEMBL1235786 | ChEMBL ↗ |
|
16370 ↗ |
COc1ccc2c(c1)C(=O)N(c1nc(C(=O)Nc3cnccc3N3CCNCC3)cs1)C2
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
20.00×103 | IC50 | CHEMBL2381116 | ChEMBL ↗ |
|
16385 ↗ |
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ccc6c5)c4c3)cc2)CC1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
6.29×103 | IC50 | CHEMBL2436978 | ChEMBL ↗ |
|
16465 ↗ |
O=C1/C(=C\c2ccc(O)c(O)c2)Oc2ccccc21
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
100.00×103 | IC50 | CHEMBL3361128 | ChEMBL ↗ |
|
17681 ↗ |
COc1cc(O)c2c(c1)/C=C/C[C@@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
1.30×103 | IC50 | CHEMBL1668411 | ChEMBL ↗ |
|
17723 ↗ |
Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
296.00 | IC50 | CHEMBL1990583 | ChEMBL ↗ |
|
18325 ↗ |
C=CC(=O)Nc1ccccc1Oc1nc(Nc2cnn(CCOC)c2)ncc1Cl
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
90.30 | IC50 | CHEMBL3884839 | ChEMBL ↗ |
|
18326 ↗ |
C=CC(=O)Nc1ccccc1Oc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1Cl
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
7.89×103 | IC50 | CHEMBL3884960 | ChEMBL ↗ |
|
18950 ↗ |
Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
1.20×103 | IC50 | CHEMBL4552628 | ChEMBL ↗ |
|
21188 ↗ |
O=C(NCCCN1CCCC1=O)c1cnc(NCc2cc(Cl)ccc2Cl)nc1NC1CCCC1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
14.19×103 | IC50 | CHEMBL2312303 | ChEMBL ↗ |
|
21189 ↗ |
O=C(NCCCN1CCOC1=O)c1cnc(NCc2cc(Cl)ccc2Cl)nc1NC1CCCC1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
15.95×103 | IC50 | CHEMBL2312304 | ChEMBL ↗ |
|
21190 ↗ |
COc1ccccc1CNc1ncc(C(=O)NC2CCN(C)CC2)c(NC2CCCC2)n1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
30.00×103 | IC50 | CHEMBL2312645 | ChEMBL ↗ |
|
21191 ↗ |
CN1CCC(NC(=O)c2cnc(NCc3cc(Cl)ccc3Cl)nc2NC2CCCC2)CC1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
30.00×103 | IC50 | CHEMBL2312646 | ChEMBL ↗ |
|
21192 ↗ |
CN1CCC(NC(=O)c2cnc(Nc3cc(Cl)cc(Cl)c3)nc2NC2CCC(N(C)C)CC2)CC1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
30.00×103 | IC50 | CHEMBL2312649 | ChEMBL ↗ |
|
21193 ↗ |
CN1CCC(NC(=O)c2cnc(Nc3cc(Cl)cc(Cl)c3)nc2N[C@@H]2COC[C@H]2O)CC1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
30.00×103 | IC50 | CHEMBL2312652 | ChEMBL ↗ |
|
21194 ↗ |
Cc1cc(-c2cnc(Nc3cc(Cl)cc(Cl)c3)nc2NC2CCC(N(C)C)CC2)on1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
30.00×103 | IC50 | CHEMBL2312654 | ChEMBL ↗ |
|
23282 ↗ |
Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
18.00×103 | IC50 | CHEMBL4550702 | ChEMBL ↗ |
|
24043 ↗ |
COc1ccc(N2Cc3cnc(Nc4ccc(F)cc4)nc3N([C@@H]3CC[C@@H](O)C3)C2=O)cc1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
12.60×103 | IC50 | CHEMBL606964 | ChEMBL ↗ |
|
37148 ↗ |
CCNC(=O)Nc1ccc2ncc(-c3ccc(OC)cc3)cc2n1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
1.13×103 | IC50 | CHEMBL3318023 | ChEMBL ↗ |
|
37149 ↗ |
Cn1cc(-c2cnc3ccc(NC(=O)NCCc4ccccc4)nc3c2)cn1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
733.00 | IC50 | CHEMBL3318030 | ChEMBL ↗ |
|
37252 ↗ |
c1ccc(-c2cnc3cncc(Nc4ccc(N5CCOCC5)cc4)c3n2)cc1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
8.43×103 | IC50 | CHEMBL3780632 | ChEMBL ↗ |
|
37253 ↗ |
c1ccc(-c2cnc3c(Nc4ccc(N5CCCCC5)cc4)nccc3n2)cc1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
1.42×103 | IC50 | CHEMBL3780758 | ChEMBL ↗ |
|
37254 ↗ |
COc1ccc(-c2cnc3cncc(Nc4ccc(N5CCCCC5)cc4)c3n2)cc1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
3.13×103 | IC50 | CHEMBL3780971 | ChEMBL ↗ |
|
37255 ↗ |
c1ccc(Nc2cncc3ncc(-c4ccc(N5CCCCC5)cc4)nc23)cc1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
12.21×103 | IC50 | CHEMBL3781028 | ChEMBL ↗ |
|
37256 ↗ |
c1ccc(-c2cnc3c(Nc4ccc(N5CCCCC5)cc4)cncc3n2)cc1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
2.34×103 | IC50 | CHEMBL3781479 | ChEMBL ↗ |
|
37257 ↗ |
COc1cccc(Nc2cncc3ncc(-c4ccc(N5CCCCC5)cc4)nc23)c1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
16.63×103 | IC50 | CHEMBL3781610 | ChEMBL ↗ |
|
37258 ↗ |
COc1ccc(-c2cnc3c(Nc4ccc(N5CCCCC5)cc4)nccc3n2)cc1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
1.44×103 | IC50 | CHEMBL3781651 | ChEMBL ↗ |
|
37259 ↗ |
COc1ccc(-c2cnc3cncc(Nc4ccc(N5CCOCC5)cc4)c3n2)cc1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
4.26×103 | IC50 | CHEMBL3781696 | ChEMBL ↗ |
|
37260 ↗ |
c1ccc(-c2cnc3cnc(Nc4ccc(N5CCCCC5)cc4)cc3n2)cc1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
23.24×103 | IC50 | CHEMBL3781795 | ChEMBL ↗ |
|
37261 ↗ |
COc1ccc(NC(=O)Nc2cncc3nc(-c4ccccc4)cnc23)cc1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
5.25×103 | IC50 | CHEMBL3781939 | ChEMBL ↗ |
|
37262 ↗ |
c1ccc(-c2cnc3cncc(Nc4ccc(N5CCCCC5)cc4)c3n2)cc1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
2.02×103 | IC50 | CHEMBL3781989 | ChEMBL ↗ |
|
37263 ↗ |
COc1ccc(-c2cnc3cncc(Nc4cc(OC)ccc4OC)c3n2)cc1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
3.79×103 | IC50 | CHEMBL3782019 | ChEMBL ↗ |
|
37430 ↗ |
COC(=O)C1=C(Nc2ccccc2Cl)O/C(=C\c2c[nH]c3ncccc23)C1=O
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
61.00 | IC50 | CHEMBL4089159 | ChEMBL ↗ |
|
37978 ↗ |
O=C1NCCc2[nH]c(-c3ccnc(-c4ccccc4F)c3)cc21
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
4.60×103 | IC50 | CHEMBL226471 | ChEMBL ↗ |
|
46419 ↗ |
CCNC(=O)Nc1ccc2ncc(-c3ccc(OC)c(OC)c3)cc2n1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
742.00 | IC50 | CHEMBL3318024 | ChEMBL ↗ |
|
46420 ↗ |
COc1ccc(-c2cnc3ccc(NC(=O)NC(C)(C)C)nc3c2)cc1OC
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
1.72×103 | IC50 | CHEMBL3318025 | ChEMBL ↗ |
|
46421 ↗ |
COc1cc(-c2cnc3ccc(NC(=O)NC(C)(C)C)nc3c2)ccc1O
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
702.00 | IC50 | CHEMBL3318026 | ChEMBL ↗ |
|
46422 ↗ |
Cn1cc(-c2cnc3ccc(NC(=O)NC(C)(C)C)nc3c2)cn1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
429.00 | IC50 | CHEMBL3318027 | ChEMBL ↗ |
|
46423 ↗ |
Cn1cc(-c2cnc3ccc(NC(=O)Nc4ccccc4)nc3c2)cn1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
191.00 | IC50 | CHEMBL3318028 | ChEMBL ↗ |
|
46424 ↗ |
Cn1cc(-c2cnc3ccc(NC(=O)NCc4ccccc4)nc3c2)cn1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
30.00 | IC50 | CHEMBL3318029 | ChEMBL ↗ |
|
46426 ↗ |
Cn1cc(-c2cnc3c(NC(=O)NC(C)(C)C)ccnc3c2)cn1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
31.60×103 | IC50 | CHEMBL3318032 | ChEMBL ↗ |
|
46850 ↗ |
COc1cc(-c2ccc3c(c2)Nc2ccc(CC(=O)Nc4ccc(N5CCOCC5)cc4)cc2NC3=O)ccc1N
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
5.00×103 | IC50 | CHEMBL395080 | ChEMBL ↗ |
|
69672 ↗ |
Cc1nn(C2CCN(C(=O)[C@@H](C)O)CC2)c(C)c1Nc1ncc(Cl)c(-c2cnn3ccccc23)n1
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
600.00 | IC50 | CHEMBL3823030 | ChEMBL ↗ |
|
70543 ↗ |
Cc1cnc(Nc2ccnn2C)nc1-c1cn2c(n1)C(=O)N(Cc1ccc(F)c(F)c1)[C@@H](C)C2
|
CHEMBL4040 ↗
UniProt: P28482 ↗ |
320.00×10-3 | IC50 | CHEMBL4440109 | ChEMBL ↗ |