CHEMBL4153 Ki
BioactivityChEMBL CHEMBL4153 Ki bioactivity data
1893 compounds · Target: Sigma non-opioid intracellular receptor 1 ( CHEMBL4153 ↗ ) · UniProt: Q60492 ↗ · Ki
Sigma non-opioid intracellular receptor 1, a molecular target studied in Cavia porcellus.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
12671 ↗ |
O=C(NCCC1CCN(Cc2ccccc2)CC1)c1cc(=O)c2cc([N+](=O)[O-])ccc2o1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
980.00×10-3 | Ki | CHEMBL4277548 | ChEMBL ↗ |
|
12715 ↗ |
Nc1ccc2oc(C(=O)NCCC3CCN(Cc4ccccc4)CC3)cc(=O)c2c1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
1.45 | Ki | CHEMBL4292477 | ChEMBL ↗ |
|
13417 ↗ |
Cc1cccc2sc(NC(=O)CCN3CCN(Cc4ccc(C(C)(C)C)cc4)CC3)nc12
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
238.00 | Ki | CHEMBL5172256 | ChEMBL ↗ |
|
13426 ↗ |
Cc1cccc2sc(NC(=O)CCN3CCN(Cc4ccccc4F)CC3)nc12
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
1.70×103 | Ki | CHEMBL5173420 | ChEMBL ↗ |
|
13441 ↗ |
CC(=O)c1ccc(N2CCN(CCC(=O)Nc3nc4c(C)cccc4s3)CC2)cc1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
1.00×103 | Ki | CHEMBL5176580 | ChEMBL ↗ |
|
13449 ↗ |
Cc1ccccc1N1CCN(CCC(=O)Nc2nc3c(C)cccc3s2)CC1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
1.00×103 | Ki | CHEMBL5178466 | ChEMBL ↗ |
|
13475 ↗ |
Cc1cccc2sc(NC(=O)CCN3CCN(C(C)C)CC3)nc12
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
1.30×103 | Ki | CHEMBL5183248 | ChEMBL ↗ |
|
13532 ↗ |
CCCCCCN1CCN(CCC(=O)Nc2nc3c(C)cccc3s2)CC1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
238.00 | Ki | CHEMBL5192784 | ChEMBL ↗ |
|
13534 ↗ |
CCCCN1CCN(CCC(=O)Nc2nc3c(C)cccc3s2)CC1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
204.00 | Ki | CHEMBL5192987 | ChEMBL ↗ |
|
13535 ↗ |
Cc1cccc2sc(NC(=O)CCN3CCN(Cc4cc(F)ccc4F)CC3)nc12
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
1.00×103 | Ki | CHEMBL5193082 | ChEMBL ↗ |
|
13551 ↗ |
Cc1cccc2sc(NC(=O)CCN3CCN(Cc4cccc5ccccc45)CC3)nc12
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
1.00×103 | Ki | CHEMBL5198012 | ChEMBL ↗ |
|
13587 ↗ |
CCOCCN1CCN(CCC(=O)Nc2nc3c(C)cccc3s2)CC1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
575.00 | Ki | CHEMBL5203299 | ChEMBL ↗ |
|
13588 ↗ |
Cc1cccc2sc(NC(=O)CCN3CCN(C4CCCCC4)CC3)nc12
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
24.00 | Ki | CHEMBL5203777 | ChEMBL ↗ |
|
13596 ↗ |
Cc1cccc2sc(NC(=O)CCN3CCN(CC4CCCCC4)CC3)nc12
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
35.00 | Ki | CHEMBL5204934 | ChEMBL ↗ |
|
13608 ↗ |
Cc1cccc2sc(NC(=O)CCN3CCN(CC4CCCO4)CC3)nc12
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
109.00 | Ki | CHEMBL5207817 | ChEMBL ↗ |
|
14903 ↗ |
O=C1CCc2ccc(OCCCN3CCCCC3)cc2N1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
89.10 | Ki | CHEMBL3235456 | ChEMBL ↗ |
|
15516 ↗ |
O=C(NCCC1CCN(Cc2ccccc2)CC1)c1cc(=O)c2cc(O)c(O)cc2o1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
27.00 | Ki | CHEMBL4280725 | ChEMBL ↗ |
|
15525 ↗ |
COc1ccc2c(=O)cc(C(=O)NCCC3CCN(Cc4ccccc4)CC3)[nH]c2c1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
45.20 | Ki | CHEMBL4282527 | ChEMBL ↗ |
|
15542 ↗ |
COc1cc2oc(C(=O)NCCC3CCN(Cc4ccccc4)CC3)cc(=O)c2cc1OC
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
37.40 | Ki | CHEMBL4287970 | ChEMBL ↗ |
|
15553 ↗ |
O=C(NCCC1CCN(Cc2ccccc2)CC1)c1cc(=O)c2cc(O)ccc2o1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
42.10 | Ki | CHEMBL4291296 | ChEMBL ↗ |
|
15967 ↗ |
COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
14.60 | Ki | CHEMBL502 | ChEMBL ↗ |
|
16134 ↗ |
c1ccc(CCN2CCCCC2)cc1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
309.00 | Ki | CHEMBL75228 | ChEMBL ↗ |
|
24633 ↗ |
CN(CCCCN1C(=O)c2ccccc2C1=O)Cc1ccccc1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
844.00 | Ki | CHEMBL3547159 | ChEMBL ↗ |
|
25083 ↗ |
O=C(NCCC1CCN(Cc2ccccc2)CC1)c1cc(=O)c2cccc(O)c2[nH]1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
47.40 | Ki | CHEMBL4285912 | ChEMBL ↗ |
|
33686 ↗ |
C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
100.00 | Ki | CHEMBL113830 | ChEMBL ↗ |
|
33912 ↗ |
COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(N(C)C)cc2)CC1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
1.26×103 | Ki | CHEMBL1688990 | ChEMBL ↗ |
|
33913 ↗ |
COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(CCF)cc2)CC1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
3.54×103 | Ki | CHEMBL1688991 | ChEMBL ↗ |
|
33966 ↗ |
c1ccc(CC2CCN(CC3COc4ccccc4O3)CC2)cc1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
16.60 | Ki | CHEMBL178700 | ChEMBL ↗ |
|
33989 ↗ |
O=C(c1ccc(F)cc1)C1CCN([C@H]2CCN(Cc3ccc(F)cc3)C[C@@H]2O)CC1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
480.00×10-3 | Ki | CHEMBL1822386 | ChEMBL ↗ |
|
34863 ↗ |
c1ccc(CN2CCN(CC3COc4ccccc4O3)CC2)cc1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
15.85 | Ki | CHEMBL359663 | ChEMBL ↗ |
|
35006 ↗ |
O[C@@H]1[C@@H](CN2CCC(Cc3ccccc3)CC2)CCC1(c1ccccc1)c1ccccc1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
229.09 | Ki | CHEMBL3769446 | ChEMBL ↗ |
|
35012 ↗ |
c1ccc(CC2CCN(CC3COC4(CCCCC4)O3)CC2)cc1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
2.00 | Ki | CHEMBL3769904 | ChEMBL ↗ |
|
35015 ↗ |
O[C@H]1[C@@H](CN2CCC(Cc3ccccc3)CC2)CCC1(c1ccccc1)c1ccccc1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
281.84 | Ki | CHEMBL3770151 | ChEMBL ↗ |
|
35021 ↗ |
O[C@H]1[C@@H](CN2CCN(Cc3ccccc3)CC2)CCC1(c1ccccc1)c1ccccc1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
35.48 | Ki | CHEMBL3770589 | ChEMBL ↗ |
|
35022 ↗ |
OCC(CN1CCC(Cc2ccccc2)CC1)OC(c1ccccc1)c1ccccc1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
199.53 | Ki | CHEMBL3770593 | ChEMBL ↗ |
|
35024 ↗ |
c1ccc(CC2CCN(CC3COC(c4ccccc4)(c4ccccc4)O3)CC2)cc1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
2.19 | Ki | CHEMBL3770830 | ChEMBL ↗ |
|
35026 ↗ |
O[C@@H]1[C@@H](CN2CCN(Cc3ccccc3)CC2)CCC1(c1ccccc1)c1ccccc1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
38.02 | Ki | CHEMBL3771016 | ChEMBL ↗ |
|
35120 ↗ |
CCCN1CC[C@H]2CC(=O)[C@H](CC)[C@H]3CCC[C@@H]1[C@H]23
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
11.00 | Ki | CHEMBL3908975 | ChEMBL ↗ |
|
35329 ↗ |
COc1cccc(-c2ccc3c(c2)CCN(Cc2ccccc2)C3)c1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
4.90 | Ki | CHEMBL4160064 | ChEMBL ↗ |
|
35333 ↗ |
CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
250.00 | Ki | CHEMBL4163428 | ChEMBL ↗ |
|
35337 ↗ |
O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
52.00 | Ki | CHEMBL4165863 | ChEMBL ↗ |
|
35340 ↗ |
COc1cccc(-c2ccc3c(c2)CN(Cc2ccccc2)C3)c1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
4.10 | Ki | CHEMBL4167315 | ChEMBL ↗ |
|
35342 ↗ |
CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
407.00 | Ki | CHEMBL4169689 | ChEMBL ↗ |
|
35348 ↗ |
O=C(OCc1ccccc1)N1Cc2ccc(N3CCN(C4CCCC4)CC3)cc2C1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
44.00 | Ki | CHEMBL4176474 | ChEMBL ↗ |
|
36592 ↗ |
O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
2.77 | Ki | CHEMBL54 | ChEMBL ↗ |
|
40089 ↗ |
OC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
2.80 | Ki | CHEMBL1036 | ChEMBL ↗ |
|
40123 ↗ |
CCCCN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
2.40 | Ki | CHEMBL11493 | ChEMBL ↗ |
|
40127 ↗ |
COc1ccc2[nH]cc(CN3CCC(O)(c4ccc(Cl)cc4)CC3)c2c1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
242.00 | Ki | CHEMBL1170094 | ChEMBL ↗ |
|
40128 ↗ |
COc1cccc2[nH]cc(CN3CCC(O)(c4ccc(Br)cc4)CC3)c12
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
2.56×103 | Ki | CHEMBL1170095 | ChEMBL ↗ |
|
40129 ↗ |
COc1ccc2[nH]cc(CN3CCC(O)(c4ccc(Br)cc4)CC3)c2c1
|
CHEMBL4153 ↗
UniProt: Q60492 ↗ |
108.00 | Ki | CHEMBL1170096 | ChEMBL ↗ |