CHEMBL4235 IC50
BioactivityChEMBL CHEMBL4235 IC50 bioactivity data
2584 compounds · Target: 11-beta-hydroxysteroid dehydrogenase 1 ( CHEMBL4235 ↗ ) · UniProt: P28845 ↗ · IC50
11-beta-hydroxysteroid dehydrogenase 1, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
11390 ↗ |
O=C1CC(c2ccccc2O)Oc2ccccc21
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
10.00×103 | IC50 | CHEMBL75897 | ChEMBL ↗ |
|
19399 ↗ |
O=C(NCc1cccnc1)C12CC3CC(CC(C3)C1)C2
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
676.00 | IC50 | CHEMBL109347 | ChEMBL ↗ |
|
19581 ↗ |
C[C@H]1[C@H](C)CC[C@]2(C(=O)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@H]12
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
1.90×103 | IC50 | CHEMBL169 | ChEMBL ↗ |
|
28603 ↗ |
NS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
3.76×103 | IC50 | CHEMBL35 | ChEMBL ↗ |
|
67494 ↗ |
CC1CN(CC(=O)N[C@H]2C3CC4CC2C[C@](C(N)=O)(C4)C3)S(=O)(=O)N(c2c(Cl)cc(Cl)cc2Cl)C1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
1.00 | IC50 | CHEMBL2036234 | ChEMBL ↗ |
|
68753 ↗ |
COc1ccc(N2C(=O)C(C)(C)C2c2ccccc2OC)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
98.00 | IC50 | CHEMBL3220615 | ChEMBL ↗ |
|
71105 ↗ |
C[C@@H]1CN(CC2(C(N)=O)CCC2)CCN1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
3.00 | IC50 | CHEMBL465956 | ChEMBL ↗ |
|
71203 ↗ |
C[C@@H]1CN(c2ccc(S(C)(=O)=O)cc2F)CCN1c1nccc(C(=O)NC2C3CC4CC2CC(O)(C4)C3)n1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
3.65 | IC50 | CHEMBL4748750 | ChEMBL ↗ |
|
71850 ↗ |
C[C@@H]1CN(CC2(c3ccc(C(N)=O)cc3)CC2)CCN1S(=O)(=O)c1ccc(C(C)(O)C(F)(F)F)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
1.20 | IC50 | CHEMBL516636 | ChEMBL ↗ |
|
86227 ↗ |
O=C(N1CCCc2ccccc21)C12CC3CC(CC(C3)C1)C2
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
1.86×103 | IC50 | CHEMBL246952 | ChEMBL ↗ |
|
131432 ↗ |
C[C@H]1[C@H](C)CC[C@]2(C(=O)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@H]12
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
810.00 | IC50 | CHEMBL391533 | ChEMBL ↗ |
|
156592 ↗ |
CCc1ccc(S(=O)(=O)N2C[C@@H]3C[C@H]2CN3C)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
3.30 | IC50 | CHEMBL1076580 | ChEMBL ↗ |
|
156593 ↗ |
CC(C)(C)c1ccc(S(=O)(=O)N2C[C@H]3CC[C@@H](C2)N3)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
547.00 | IC50 | CHEMBL1076594 | ChEMBL ↗ |
|
156594 ↗ |
CN1C[C@@H]2C[C@H]1CN2S(=O)(=O)c1ccc(Cl)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
11.30 | IC50 | CHEMBL1076600 | ChEMBL ↗ |
|
156595 ↗ |
CO/N=C1/C[C@H]2CC[C@@H](C1)N2S(=O)(=O)c1ccc(C(C)(C)C)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
860.00 | IC50 | CHEMBL1076683 | ChEMBL ↗ |
|
156596 ↗ |
CC(C)(C)c1ccc(S(=O)(=O)N2[C@@H]3CC[C@H]2CC(O)(O)C3)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
1.62×103 | IC50 | CHEMBL1079975 | ChEMBL ↗ |
|
156597 ↗ |
CC(C)(C)c1ccc(S(=O)(=O)N2[C@@H]3CC[C@@]2(C)CC(O)(O)C3)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
740.00 | IC50 | CHEMBL1080158 | ChEMBL ↗ |
|
156598 ↗ |
CC(C)(C)c1ccc(S(=O)(=O)N2[C@@H]3CC[C@H]2C/C(=N\OCc2ccccc2)C3)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
159.00 | IC50 | CHEMBL1080557 | ChEMBL ↗ |
|
156599 ↗ |
CN1C[C@@H]2C[C@H]1CN2S(=O)(=O)c1ccc(CC(C)(C)C)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
330.00×10-3 | IC50 | CHEMBL1080752 | ChEMBL ↗ |
|
156600 ↗ |
COC1C[C@H]2CC[C@@H](C1)N2S(=O)(=O)c1ccc(C(C)(C)C)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
53.00 | IC50 | CHEMBL1080885 | ChEMBL ↗ |
|
156601 ↗ |
CCOC1C[C@H]2CC[C@@H](C1)N2S(=O)(=O)c1ccc(C(C)(C)C)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
114.00 | IC50 | CHEMBL1080886 | ChEMBL ↗ |
|
156602 ↗ |
COc1ccc(S(=O)(=O)N2C[C@@H]3C[C@H]2CN3C)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
16.10 | IC50 | CHEMBL1080922 | ChEMBL ↗ |
|
156603 ↗ |
CC(C)(C)OC(=O)N1C[C@@H]2C[C@H]1CN2S(=O)(=O)c1ccc(C(C)(C)C)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
361.00 | IC50 | CHEMBL1080935 | ChEMBL ↗ |
|
156604 ↗ |
CC(C)(C)c1ccc(S(=O)(=O)N2[C@@H]3CC[C@H]2C/C(=N\O)C3)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
270.00 | IC50 | CHEMBL1081078 | ChEMBL ↗ |
|
156605 ↗ |
CN1C[C@@H]2C[C@H]1CN2S(=O)(=O)c1ccc(C(C)(C)C)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
110.00×10-3 | IC50 | CHEMBL1081251 | ChEMBL ↗ |
|
156606 ↗ |
CC(C)(C)c1ccc(S(=O)(=O)N2C[C@@H]3C[C@H]2CN3C2CCCC2)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
40.00 | IC50 | CHEMBL1081297 | ChEMBL ↗ |
|
156607 ↗ |
CC(C)(C)OC(=O)N1[C@@H]2CC[C@H]1CN(S(=O)(=O)c1ccc(C(C)(C)C)cc1)C2
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
309.00 | IC50 | CHEMBL1081298 | ChEMBL ↗ |
|
156608 ↗ |
CN1[C@@H]2CC[C@H]1CN(S(=O)(=O)c1ccc(C(C)(C)C)cc1)C2
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
478.00 | IC50 | CHEMBL1081299 | ChEMBL ↗ |
|
156609 ↗ |
CC(C)(C)c1ccc(S(=O)(=O)N2C[C@@H]3C[C@H]2CN3)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
4.40×103 | IC50 | CHEMBL1081452 | ChEMBL ↗ |
|
156610 ↗ |
CC(C)(C)c1ccc(S(=O)(=O)N2C[C@@H]3C[C@H]2CN3C2CC3CCC2C3)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
76.00 | IC50 | CHEMBL1081453 | ChEMBL ↗ |
|
156611 ↗ |
CC(C)(C)c1ccc(S(=O)(=O)N2C[C@@H]3C[C@H]2CN3C2CCCCC2)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
118.00 | IC50 | CHEMBL1081803 | ChEMBL ↗ |
|
156612 ↗ |
CC(C)(C)c1ccc(S(=O)(=O)N2C[C@H]3CC[C@@H](C2)N3C2CCCC2)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
137.00 | IC50 | CHEMBL1082165 | ChEMBL ↗ |
|
156613 ↗ |
CC1(O)C[C@H]2CC[C@@H](C1)N2S(=O)(=O)c1ccc(C(C)(C)C)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
19.00 | IC50 | CHEMBL1082196 | ChEMBL ↗ |
|
156614 ↗ |
COC1(C)C[C@H]2CC[C@@H](C1)N2S(=O)(=O)c1ccc(C(C)(C)C)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
14.00 | IC50 | CHEMBL1082197 | ChEMBL ↗ |
|
156615 ↗ |
O=C(CCc1nnnn1-c1ccccc1)C1CCCCC1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
506.00 | IC50 | CHEMBL1082490 | ChEMBL ↗ |
|
156616 ↗ |
O=C(COc1cnnn1-c1ccccc1)c1ccccc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
971.00 | IC50 | CHEMBL1082497 | ChEMBL ↗ |
|
156617 ↗ |
O=C(CCc1cnnn1Cc1ccccc1)c1ccccc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
2.10×103 | IC50 | CHEMBL1082499 | ChEMBL ↗ |
|
156618 ↗ |
O=C(CCn1nnnc1-c1cccc(Cl)c1)c1ccccc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
1.10×103 | IC50 | CHEMBL1082768 | ChEMBL ↗ |
|
156619 ↗ |
O=C(CCn1nnnc1-c1cccnc1)c1ccccc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
3.90×103 | IC50 | CHEMBL1082770 | ChEMBL ↗ |
|
156620 ↗ |
O=C(CCn1nnnc1-c1ccccc1)c1ccccc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
843.00 | IC50 | CHEMBL1082813 | ChEMBL ↗ |
|
156621 ↗ |
COc1ccccc1-c1nnnn1CCC(=O)c1ccccc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
751.00 | IC50 | CHEMBL1082814 | ChEMBL ↗ |
|
156622 ↗ |
CC(=O)CSc1cnnn1-c1ccccc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
14.50×103 | IC50 | CHEMBL1082938 | ChEMBL ↗ |
|
156623 ↗ |
COc1cccc(C(=O)CCc2cnnn2-c2ccccc2)c1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
215.00 | IC50 | CHEMBL1083125 | ChEMBL ↗ |
|
156624 ↗ |
CC(C)(C)C(=O)CSc1cnnn1-c1ccccc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
252.00 | IC50 | CHEMBL1083161 | ChEMBL ↗ |
|
156625 ↗ |
COc1ccc(C(=O)CSc2cnnn2-c2ccccc2)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
1.05×103 | IC50 | CHEMBL1083267 | ChEMBL ↗ |
|
156626 ↗ |
O=C(CCn1nnnc1-c1ccc2c(c1)OCO2)c1ccccc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
722.00 | IC50 | CHEMBL1083395 | ChEMBL ↗ |
|
156627 ↗ |
O=C(CCc1cnnn1C1CCOCC1)c1ccccc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
2.40×103 | IC50 | CHEMBL1083422 | ChEMBL ↗ |
|
156628 ↗ |
O=C(CCc1nnnn1-c1ccccc1)Cc1ccccc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
820.00 | IC50 | CHEMBL1083423 | ChEMBL ↗ |
|
156629 ↗ |
COc1cccc(-n2nncc2CCC(=O)c2ccccc2)c1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
304.00 | IC50 | CHEMBL1083464 | ChEMBL ↗ |
|
156630 ↗ |
N#Cc1ccc(-n2nncc2CCC(=O)c2ccccc2)cc1
|
CHEMBL4235 ↗
UniProt: P28845 ↗ |
686.00 | IC50 | CHEMBL1083465 | ChEMBL ↗ |