CHEMBL4282 IC50
BioactivityChEMBL CHEMBL4282 IC50 bioactivity data
1684 compounds · Target: RAC-alpha serine/threonine-protein kinase ( CHEMBL4282 ↗ ) · UniProt: P31749 ↗ · IC50
RAC-alpha serine/threonine-protein kinase, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
5862 ↗ |
Cc1cc(Nc2nc(Nc3ccccc3S(=O)(=O)C(C)C)c3c(C)[nH]nc3n2)c(OC(C)C)cc1C1CCN(C)CC1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
7.60×103 | IC50 | CHEMBL3651854 | ChEMBL ↗ |
|
5928 ↗ |
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
10.00×103 | IC50 | CHEMBL3884319 | ChEMBL ↗ |
|
6315 ↗ |
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
80.00 | IC50 | CHEMBL4568087 | ChEMBL ↗ |
|
6316 ↗ |
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
24.00×103 | IC50 | CHEMBL4569508 | ChEMBL ↗ |
|
6393 ↗ |
N=C(N)SCCCn1c(=O)c2c(c1=O)n1c3ccccc3cc1c1cccc3ccn2c31
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
9.00×103 | IC50 | CHEMBL489083 | ChEMBL ↗ |
|
6407 ↗ |
O=C(NCCc1ccc(O)c(Br)c1)/C(Cc1cc(Br)c(O)c(-c2cc(C/C(=N/O)C(=O)NCCc3ccc(O)c(Br)c3)cc(Br)c2O)c1)=N\O
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
1.90×103 | IC50 | CHEMBL505637 | ChEMBL ↗ |
|
6570 ↗ |
O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
3.34×103 | IC50 | CHEMBL6246 | ChEMBL ↗ |
|
6724 ↗ |
Cc1c(O)c(O)c2c(c1C=O)[C@@H]1O[C@H](O2)c2c(C)c(O)c(O)c(O)c2C1=O
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
2.15×103 | IC50 | CHEMBL3104851 | ChEMBL ↗ |
|
6725 ↗ |
Cc1c(O)c(O)c(O)c(C=O)c1-c1cc2c(C=O)c(C)c(O)c(O)c2o1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
4.07×103 | IC50 | CHEMBL3104855 | ChEMBL ↗ |
|
13340 ↗ |
O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
5.39×103 | IC50 | CHEMBL50 | ChEMBL ↗ |
|
16370 ↗ |
COc1ccc2c(c1)C(=O)N(c1nc(C(=O)Nc3cnccc3N3CCNCC3)cs1)C2
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
4.80×103 | IC50 | CHEMBL2381116 | ChEMBL ↗ |
|
16451 ↗ |
Cc1c(O)c(O)c(O)c2c1COC2=O
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
23.20×103 | IC50 | CHEMBL3104854 | ChEMBL ↗ |
|
16452 ↗ |
CC1=CCC[C@H]2[C@](C)(CC3=C(O)C(=O)C=C(NCCC(C)C)C3=O)[C@@H](C)CC[C@@]12C
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
73.20×103 | IC50 | CHEMBL3109401 | ChEMBL ↗ |
|
16454 ↗ |
COC(=O)c1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@@]3(C)C(C)=CCC[C@@H]23)c1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
48.40×103 | IC50 | CHEMBL3109404 | ChEMBL ↗ |
|
16465 ↗ |
O=C1/C(=C\c2ccc(O)c(O)c2)Oc2ccccc21
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
38.60×103 | IC50 | CHEMBL3361128 | ChEMBL ↗ |
|
16996 ↗ |
CNc1ncnc(-c2cccnc2Oc2ccc(F)c(C(=O)Nc3cc(C(F)(F)F)ccc3N(C)CCCN(C)C)c2)n1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
100.00×103 | IC50 | CHEMBL373882 | ChEMBL ↗ |
|
17017 ↗ |
Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
7.00×103 | IC50 | CHEMBL3787112 | ChEMBL ↗ |
|
17835 ↗ |
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
50.00×103 | IC50 | CHEMBL223360 | ChEMBL ↗ |
|
18950 ↗ |
Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
870.00 | IC50 | CHEMBL4552628 | ChEMBL ↗ |
|
21190 ↗ |
COc1ccccc1CNc1ncc(C(=O)NC2CCN(C)CC2)c(NC2CCCC2)n1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
30.00×103 | IC50 | CHEMBL2312645 | ChEMBL ↗ |
|
21191 ↗ |
CN1CCC(NC(=O)c2cnc(NCc3cc(Cl)ccc3Cl)nc2NC2CCCC2)CC1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
18.58×103 | IC50 | CHEMBL2312646 | ChEMBL ↗ |
|
21192 ↗ |
CN1CCC(NC(=O)c2cnc(Nc3cc(Cl)cc(Cl)c3)nc2NC2CCC(N(C)C)CC2)CC1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
30.00×103 | IC50 | CHEMBL2312649 | ChEMBL ↗ |
|
21193 ↗ |
CN1CCC(NC(=O)c2cnc(Nc3cc(Cl)cc(Cl)c3)nc2N[C@@H]2COC[C@H]2O)CC1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
30.00×103 | IC50 | CHEMBL2312652 | ChEMBL ↗ |
|
21194 ↗ |
Cc1cc(-c2cnc(Nc3cc(Cl)cc(Cl)c3)nc2NC2CCC(N(C)C)CC2)on1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
3.10×103 | IC50 | CHEMBL2312654 | ChEMBL ↗ |
|
37049 ↗ |
O=C1Nc2ccccc2/C1=C/c1c[nH]nc1-c1ccccc1[N+](=O)[O-]
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
11.00 | IC50 | CHEMBL2347053 | ChEMBL ↗ |
|
46850 ↗ |
COc1cc(-c2ccc3c(c2)Nc2ccc(CC(=O)Nc4ccc(N5CCOCC5)cc4)cc2NC3=O)ccc1N
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
880.00 | IC50 | CHEMBL395080 | ChEMBL ↗ |
|
68174 ↗ |
NC1(C(=O)N[C@@H](CCN2CCCC2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
4.00 | IC50 | CHEMBL2325728 | ChEMBL ↗ |
|
68175 ↗ |
NC1(C(=O)N[C@@H](CCN2CCCCC2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
4.00 | IC50 | CHEMBL2325729 | ChEMBL ↗ |
|
68176 ↗ |
CS(=O)(=O)NCCC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
7.00 | IC50 | CHEMBL2325736 | ChEMBL ↗ |
|
68177 ↗ |
NC1(C(=O)NC(CCCO)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
6.00 | IC50 | CHEMBL2325739 | ChEMBL ↗ |
|
68178 ↗ |
COCCC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
10.00 | IC50 | CHEMBL2325740 | ChEMBL ↗ |
|
68179 ↗ |
C[C@@H](NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
276.00 | IC50 | CHEMBL2325742 | ChEMBL ↗ |
|
68180 ↗ |
C[C@H](NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
4.00 | IC50 | CHEMBL2325743 | ChEMBL ↗ |
|
68181 ↗ |
CCC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
7.00 | IC50 | CHEMBL2325982 | ChEMBL ↗ |
|
68182 ↗ |
NC1(C(=O)NC(c2ccc(Cl)cc2)C2CC2)CCN(c2ncnc3[nH]ccc23)CC1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
5.00 | IC50 | CHEMBL2325983 | ChEMBL ↗ |
|
68183 ↗ |
NC1(C(=O)NC(c2ccccc2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
41.00 | IC50 | CHEMBL2325984 | ChEMBL ↗ |
|
68184 ↗ |
NC1(C(=O)NC(Cc2ccccc2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
31.00 | IC50 | CHEMBL2325985 | ChEMBL ↗ |
|
68185 ↗ |
CC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(F)cc1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
9.00 | IC50 | CHEMBL2325987 | ChEMBL ↗ |
|
68186 ↗ |
NC1(C(=O)NC(CCCN2CCOCC2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
5.00 | IC50 | CHEMBL2325995 | ChEMBL ↗ |
|
68187 ↗ |
CC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
8.00 | IC50 | CHEMBL2325997 | ChEMBL ↗ |
|
70603 ↗ |
Cc1nnc2c3cc(-c4ccccc4)c(-c4ccc(CN5CCC(c6n[nH]c(-c7ccccn7)n6)CC5)cc4)nc3ccn12
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
4.60 | IC50 | CHEMBL445464 | ChEMBL ↗ |
|
71725 ↗ |
Nc1nnc2c3cc(-c4ccccc4)c(-c4ccc(CN5CCC(c6n[nH]c(-c7ccccn7)n6)CC5)cc4)nc3ccn12
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
2.80 | IC50 | CHEMBL499555 | ChEMBL ↗ |
|
71742 ↗ |
Oc1nnc2c3cc(-c4ccccc4)c(-c4ccc(CN5CCC(c6n[nH]c(-c7ccccn7)n6)CC5)cc4)nc3ccn12
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
2.60 | IC50 | CHEMBL506077 | ChEMBL ↗ |
|
71798 ↗ |
ClCc1nnc2c3cc(-c4ccccc4)c(-c4ccc(CN5CCC(c6n[nH]c(-c7ccccn7)n6)CC5)cc4)nc3ccn12
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
26.70 | IC50 | CHEMBL508861 | ChEMBL ↗ |
|
71876 ↗ |
CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
41.50 | IC50 | CHEMBL521851 | ChEMBL ↗ |
|
72210 ↗ |
Cc1occc1-c1nc(N)c(OC[C@@H](N)Cc2c[nH]c3ccccc23)cc1-c1cnc2[nH]nc(C)c2n1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
1.00 | IC50 | CHEMBL595944 | ChEMBL ↗ |
|
72217 ↗ |
NC1(C(=O)NCc2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
13.00 | IC50 | CHEMBL598194 | ChEMBL ↗ |
|
93029 ↗ |
N#CC(=C(/N)Sc1ccccc1N)/C(C#N)=C(\N)Sc1ccccc1N
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
60.00×103 | IC50 | CHEMBL34704 | ChEMBL ↗ |
|
93230 ↗ |
O=C1/C(=C/c2ccccc2F)CNC/C1=C\c1ccccc1F
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
780.00 | IC50 | CHEMBL379849 | ChEMBL ↗ |
|
94053 ↗ |
O=C1/C(=C/c2ccccn2)CNC/C1=C\c1ccccn1
|
CHEMBL4282 ↗
UniProt: P31749 ↗ |
20.00 | IC50 | CHEMBL574646 | ChEMBL ↗ |