CHEMBL4409 IC50
BioactivityChEMBL CHEMBL4409 IC50 bioactivity data
2613 compounds · Target: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A ( CHEMBL4409 ↗ ) · UniProt: Q9Y233 ↗ · IC50
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
36498 ↗ |
COc1cc2ncnc(N3CCC(CN4CCN(c5ccc(Cl)cc5)CC4)C3)c2cc1OC
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
1.70×103 | IC50 | CHEMBL5189417 | ChEMBL ↗ |
|
36558 ↗ |
COc1cccc(N2CCN(CC3CCN(c4ncnc5cc(OC)c(OC)cc45)C3)CC2)c1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
7.08×103 | IC50 | CHEMBL5209272 | ChEMBL ↗ |
|
36559 ↗ |
COc1cc2ncnc(N3CCC(CN4CCN(c5ccccc5O)CC4)C3)c2cc1OC
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
6.03×103 | IC50 | CHEMBL5209283 | ChEMBL ↗ |
|
66601 ↗ |
O=c1n(Cc2ccc(Cl)cc2)c2sc3c(c2c2ncnn12)CCCC3
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
3.50×103 | IC50 | CHEMBL1463540 | ChEMBL ↗ |
|
69920 ↗ |
COc1ccc(Cn2c(=O)n3ncnc3c3c4c(sc32)CN(CC2CCOCC2)CC4)c(F)c1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
690.00 | IC50 | CHEMBL4067682 | ChEMBL ↗ |
|
69953 ↗ |
O=C(C1CC1)N1CCc2c(sc3c2c2ncnn2c(=O)n3Cc2ccc(Cl)cc2)C1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
1.20×103 | IC50 | CHEMBL4074038 | ChEMBL ↗ |
|
70077 ↗ |
COc1ccc(Cn2c(=O)n3ncnc3c3c4c(sc32)CN(C(=O)C2CC2(F)F)CC4)cc1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
59.00 | IC50 | CHEMBL4094575 | ChEMBL ↗ |
|
70082 ↗ |
COc1ccc(Cn2c(=O)n3ncnc3c3c4c(sc32)CN(CC2CCOCC2)CC4(F)F)cc1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
1.70×103 | IC50 | CHEMBL4095097 | ChEMBL ↗ |
|
70134 ↗ |
COc1ccc(Cn2c(=O)n3ncnc3c3c4c(sc32)CN(CC2CCOCC2)CC4)cc1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
1.60×103 | IC50 | CHEMBL4102858 | ChEMBL ↗ |
|
70607 ↗ |
COc1cc(F)cc2c1nnc1c2c(-c2ccncc2C)nn1C
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
21.00 | IC50 | CHEMBL4456157 | ChEMBL ↗ |
|
70839 ↗ |
Cc1ccc2c(c1)nc(CCN1C(=O)c3cccc4cccc(c34)C1=O)n2-c1ccncc1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
440.00×10-3 | IC50 | CHEMBL4558162 | ChEMBL ↗ |
|
71056 ↗ |
C[C@@H](Nc1nc2c(cnn2C(C)(C)C)c(=O)n1Cc1ccc(F)cc1)c1ccc(Cl)cc1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
1.77×103 | IC50 | CHEMBL4644729 | ChEMBL ↗ |
|
71294 ↗ |
C[C@@H](c1cc(OCC(F)F)ccn1)n1cnc2c(N)nc(Cl)nc21
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
4.40×103 | IC50 | CHEMBL4762103 | ChEMBL ↗ |
|
84421 ↗ |
CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
6.10×103 | IC50 | CHEMBL192 | ChEMBL ↗ |
|
94609 ↗ |
N#Cc1ccc2nc(Nc3ccc(Oc4ncccc4C(F)(F)F)cc3)[nH]c2c1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
112.00 | IC50 | CHEMBL2071607 | ChEMBL ↗ |
|
103218 ↗ |
N#Cc1c(-c2ccc(-c3ccccc3OC(F)(F)F)cc2)nc2ccncc2c1O
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
1.00 | IC50 | CHEMBL1957366 | ChEMBL ↗ |
|
103291 ↗ |
COc1ccc(C2=NN(C3CCCCCC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OCCCCOc1ccc(-c2nnn[nH]2)cc1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
501.19 | IC50 | CHEMBL2326941 | ChEMBL ↗ |
|
103497 ↗ |
COc1cc2ccccc2nc1COc1ccc(-c2nn(C)cc2-c2ccncc2)cc1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
400.00×10-3 | IC50 | CHEMBL3218036 | ChEMBL ↗ |
|
103498 ↗ |
COc1cc(COc2ccc(-c3nn(C)cc3-c3ccncc3)cc2)nc2ccccc12
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
280.00×10-3 | IC50 | CHEMBL3218037 | ChEMBL ↗ |
|
103499 ↗ |
COc1ccc2nc(COc3ccc(-c4nn(C)cc4-c4ccncc4)cc3)ccc2c1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
1.82 | IC50 | CHEMBL3218039 | ChEMBL ↗ |
|
103501 ↗ |
COc1cc2ccccc2nc1COc1ccc(-c2c(-c3ccncc3)cnn2C)cc1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
240.00×10-3 | IC50 | CHEMBL3222273 | ChEMBL ↗ |
|
103502 ↗ |
COc1cc(COc2ccc(-c3c(-c4ccncc4)cnn3C)cc2)nc2ccccc12
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
360.00×10-3 | IC50 | CHEMBL3222274 | ChEMBL ↗ |
|
103503 ↗ |
COc1ccc2nc(COc3ccc(-c4c(-c5ccncc5)cnn4C)cc3)ccc2c1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
1.78 | IC50 | CHEMBL3222276 | ChEMBL ↗ |
|
103631 ↗ |
COc1cc2nncc(-c3cnc(N4CCC(O)(c5cccnc5)CC4)c(C)c3)c2cc1OC
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
1.52 | IC50 | CHEMBL3393194 | ChEMBL ↗ |
|
103632 ↗ |
COc1cc2nncc(-c3cnc(N4CCC(O)(c5ccc(F)nc5)CC4)c(C)c3)c2cc1OC
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
2.86 | IC50 | CHEMBL3393195 | ChEMBL ↗ |
|
103633 ↗ |
Cn1c(C(=O)c2ccc(Oc3ncccc3-c3cccnc3)cc2)nc2ccccc21
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
3.73 | IC50 | CHEMBL3393204 | ChEMBL ↗ |
|
103668 ↗ |
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(F)c4ccccc4n3)cc2)n1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
710.00×10-3 | IC50 | CHEMBL3628713 | ChEMBL ↗ |
|
103669 ↗ |
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(CF)c4ccccc4n3)cc2)n1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
680.00×10-3 | IC50 | CHEMBL3628714 | ChEMBL ↗ |
|
103670 ↗ |
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(CCCF)c4ccccc4n3)cc2)n1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
1.80 | IC50 | CHEMBL3628715 | ChEMBL ↗ |
|
103671 ↗ |
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(OCCF)c4ccccc4n3)cc2)n1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
320.00×10-3 | IC50 | CHEMBL3628716 | ChEMBL ↗ |
|
103672 ↗ |
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(COCCF)c4ccccc4n3)cc2)n1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
650.00×10-3 | IC50 | CHEMBL3628717 | ChEMBL ↗ |
|
103673 ↗ |
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(OCCOCCF)c4ccccc4n3)cc2)n1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
270.00×10-3 | IC50 | CHEMBL3628718 | ChEMBL ↗ |
|
103674 ↗ |
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(OCCOCCOCCF)c4ccccc4n3)cc2)n1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
240.00×10-3 | IC50 | CHEMBL3628719 | ChEMBL ↗ |
|
103675 ↗ |
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(OCCOCCOCCOCCF)c4ccccc4n3)cc2)n1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
330.00×10-3 | IC50 | CHEMBL3628720 | ChEMBL ↗ |
|
103676 ↗ |
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(NCCF)c4ccccc4n3)cc2)n1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
520.00×10-3 | IC50 | CHEMBL3628721 | ChEMBL ↗ |
|
103677 ↗ |
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3cc(-n4cc(CCF)nn4)c4ccccc4n3)cc2)n1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
3.07 | IC50 | CHEMBL3628722 | ChEMBL ↗ |
|
103678 ↗ |
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3nc4ccccc4cc3OCCF)cc2)n1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
260.00×10-3 | IC50 | CHEMBL3628723 | ChEMBL ↗ |
|
103679 ↗ |
Cn1cc(-c2ccncc2)c(-c2ccc(OCc3ccc4cc(F)ccc4n3)cc2)n1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
290.00×10-3 | IC50 | CHEMBL3628724 | ChEMBL ↗ |
|
103681 ↗ |
Cn1ncc(-c2ccncc2)c1-c1ccc(OCc2cc(OCCF)c3ccccc3n2)cc1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
1.16 | IC50 | CHEMBL3628994 | ChEMBL ↗ |
|
103682 ↗ |
Cn1ncc(-c2ccncc2)c1-c1ccc(OCc2cc(COCCF)c3ccccc3n2)cc1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
1.12 | IC50 | CHEMBL3628995 | ChEMBL ↗ |
|
103683 ↗ |
Cn1ncc(-c2ccncc2)c1-c1ccc(OCc2cc(OCCOCCF)c3ccccc3n2)cc1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
360.00×10-3 | IC50 | CHEMBL3628996 | ChEMBL ↗ |
|
103684 ↗ |
Cn1ncc(-c2ccncc2)c1-c1ccc(OCc2cc(OCCOCCOCCF)c3ccccc3n2)cc1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
470.00×10-3 | IC50 | CHEMBL3628997 | ChEMBL ↗ |
|
103685 ↗ |
Cn1ncc(-c2ccncc2)c1-c1ccc(OCc2cc(OCCOCCOCCOCCF)c3ccccc3n2)cc1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
300.00×10-3 | IC50 | CHEMBL3628998 | ChEMBL ↗ |
|
103686 ↗ |
Cn1ncc(-c2ccncc2)c1-c1ccc(OCc2cc(NCCF)c3ccccc3n2)cc1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
370.00×10-3 | IC50 | CHEMBL3628999 | ChEMBL ↗ |
|
103687 ↗ |
Cn1ncc(-c2ccncc2)c1-c1ccc(OCc2cc(-n3cc(CCF)nn3)c3ccccc3n2)cc1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
4.98 | IC50 | CHEMBL3629000 | ChEMBL ↗ |
|
103688 ↗ |
Cn1ncc(-c2ccncc2)c1-c1ccc(OCc2ccc3cc(F)ccc3n2)cc1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
760.00×10-3 | IC50 | CHEMBL3629001 | ChEMBL ↗ |
|
103853 ↗ |
CN(C)C(=O)c1cccc(S(=O)(=O)N2CCS[C@H]2C(=O)O[C@@H](Cc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)c1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
810.00 | IC50 | CHEMBL4075951 | ChEMBL ↗ |
|
103894 ↗ |
CN(C)C(=O)c1cccc(S(=O)(=O)N2CCC[C@H]2C(=O)O[C@@H](Cc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(OC(F)F)c(OCC3CC3)c2)c1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
4.03×103 | IC50 | CHEMBL4093768 | ChEMBL ↗ |
|
104156 ↗ |
CC(C)Nc1nccc(-c2c(C3CC3)nn3ccccc23)n1
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
7.40×103 | IC50 | CHEMBL4777781 | ChEMBL ↗ |
|
104235 ↗ |
COc1c(OCc2ccc(F)cc2)cc2oc3cc4c(c(OC/C=C/C(=O)O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4
|
CHEMBL4409 ↗
UniProt: Q9Y233 ↗ |
260.00 | IC50 | CHEMBL4877549 | ChEMBL ↗ |