CHEMBL4523 IC50
BioactivityChEMBL CHEMBL4523 IC50 bioactivity data
1124 compounds · Target: Serine/threonine-protein kinase pim-2 ( CHEMBL4523 ↗ ) · UniProt: Q9P1W9 ↗ · IC50
Serine/threonine-protein kinase pim-2, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
6390 ↗ |
CC(C)Oc1cc(F)ccc1Nc1ncnc2ccc(-c3ccc(C(=O)N4CCNCC4)cc3)nc12
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
232.00 | IC50 | CHEMBL4869634 | ChEMBL ↗ |
|
17669 ↗ |
O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
186.00 | IC50 | CHEMBL1230165 | ChEMBL ↗ |
|
17716 ↗ |
COc1cc(NCC2CCNCC2)nc2c1nnn2-c1cccc(OC(F)(F)F)c1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
29.00 | IC50 | CHEMBL1952142 | ChEMBL ↗ |
|
17717 ↗ |
CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
362.50 | IC50 | CHEMBL1952329 | ChEMBL ↗ |
|
18076 ↗ |
O[C@H]1CC[C@H](Nc2ccn3ncc(-c4cccc(OC(F)(F)F)c4)c3n2)CC1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
269.00 | IC50 | CHEMBL3355544 | ChEMBL ↗ |
|
18077 ↗ |
O[C@H]1CC[C@H](Nc2ccn3ncc(-c4cccc(C(F)(F)F)c4)c3n2)CC1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
282.00 | IC50 | CHEMBL3355550 | ChEMBL ↗ |
|
18078 ↗ |
CC(C)(O)[C@H]1CC[C@H](Nc2ccn3ncc(-c4cccc(C(F)(F)F)c4)c3n2)CC1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
525.00 | IC50 | CHEMBL3355552 | ChEMBL ↗ |
|
18079 ↗ |
CC(C)(O)[C@H]1CC[C@H](Nc2ccn3ncc(-c4cccc(Cl)c4)c3n2)CC1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
228.00 | IC50 | CHEMBL3355987 | ChEMBL ↗ |
|
18295 ↗ |
C[C@H]1CN(c2cccc3nc(-c4nc(-c5cc(C(=O)N(C)C)ccn5)cnc4N)n(C)c23)CCN1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
730.00 | IC50 | CHEMBL3800585 | ChEMBL ↗ |
|
18895 ↗ |
CN1CCOc2c1cnn1c(-c3ccc4c(F)c(F)cc(NCC5(F)CCNCC5)c4n3)nnc21
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
3.59×103 | IC50 | CHEMBL4526558 | ChEMBL ↗ |
|
18898 ↗ |
CN1CCOc2c1cnn1c(-c3ccc4c(F)ccc(NCC5(F)CCNCC5)c4n3)nnc21
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
3.01×103 | IC50 | CHEMBL4527736 | ChEMBL ↗ |
|
23128 ↗ |
Cc1nc2c(F)cc(-c3nc(Nc4ccc5c(n4)CCN(CCN(C)C)C5)ncc3F)cc2n1C(C)C
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
177.00 | IC50 | CHEMBL4448494 | ChEMBL ↗ |
|
36760 ↗ |
O=C(O)c1cc2cc(-c3cccnc3)ccc2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
7.10×103 | IC50 | CHEMBL1204914 | ChEMBL ↗ |
|
36762 ↗ |
O=Cc1c[nH]c2c1ccc1c2[nH]c2cccc(Br)c21
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
131.00 | IC50 | CHEMBL1240961 | ChEMBL ↗ |
|
36771 ↗ |
O=C(O)c1ccc2nc(Nc3cccc(Cl)c3)c3ccncc3c2c1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
294.00 | IC50 | CHEMBL1649586 | ChEMBL ↗ |
|
36772 ↗ |
NC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
1.25×103 | IC50 | CHEMBL1649761 | ChEMBL ↗ |
|
36773 ↗ |
O=C(O)c1cccc2c1nc(Nc1cccc(Cl)c1)c1ccncc12
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
94.00 | IC50 | CHEMBL1649765 | ChEMBL ↗ |
|
36777 ↗ |
O=C(O)c1cc2cc(C(F)(F)F)ccc2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
13.50×103 | IC50 | CHEMBL1782505 | ChEMBL ↗ |
|
36779 ↗ |
O=C(O)c1cc2cc(-c3cnccn3)ccc2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
11.90×103 | IC50 | CHEMBL1782507 | ChEMBL ↗ |
|
36780 ↗ |
Cn1cc(-c2ccc3oc(C(=O)O)cc3c2)cn1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
2.90×103 | IC50 | CHEMBL1782508 | ChEMBL ↗ |
|
36781 ↗ |
O=C(O)c1cc2cc(-c3cncc(NCC4CCNCC4)n3)ccc2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
160.00 | IC50 | CHEMBL1782509 | ChEMBL ↗ |
|
36782 ↗ |
O=C(O)c1cc2cc(-c3cnn(C4CCNCC4)c3)ccc2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
5.80×103 | IC50 | CHEMBL1782510 | ChEMBL ↗ |
|
36783 ↗ |
NCCCCNc1ccnc(-c2ccc3oc(C(=O)O)cc3c2)n1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
1.20×103 | IC50 | CHEMBL1782511 | ChEMBL ↗ |
|
36784 ↗ |
NCCCCNc1nccc(-c2ccc3oc(C(=O)O)cc3c2)n1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
590.00 | IC50 | CHEMBL1782512 | ChEMBL ↗ |
|
36785 ↗ |
N[C@H]1CC[C@H](Nc2cncc(-c3ccc4oc(C(=O)O)cc4c3)n2)CC1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
54.00 | IC50 | CHEMBL1782513 | ChEMBL ↗ |
|
36786 ↗ |
N[C@H]1CC[C@@H](Nc2cncc(-c3ccc4oc(C(=O)O)cc4c3)n2)CC1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
110.00 | IC50 | CHEMBL1782514 | ChEMBL ↗ |
|
36787 ↗ |
O=C(O)c1cc2cc(-c3cncc(NC4CCNCC4)n3)ccc2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
150.00 | IC50 | CHEMBL1782515 | ChEMBL ↗ |
|
36788 ↗ |
NC[C@H]1CC[C@H](Nc2cncc(-c3ccc4oc(C(=O)O)cc4c3)n2)CC1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
21.00 | IC50 | CHEMBL1782516 | ChEMBL ↗ |
|
36789 ↗ |
O=C(O)c1cc2cc(-c3cncc(NC4CNC4)n3)ccc2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
100.00 | IC50 | CHEMBL1782517 | ChEMBL ↗ |
|
36790 ↗ |
O=C(O)c1cc2cc(Br)cc(OCC3CCNCC3)c2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
250.00 | IC50 | CHEMBL1782518 | ChEMBL ↗ |
|
36791 ↗ |
O=C(O)c1cc2cc(Br)cc(OCc3ccncc3)c2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
12.50×103 | IC50 | CHEMBL1782519 | ChEMBL ↗ |
|
36792 ↗ |
O=C(O)c1cc2cc(Br)cc(OCC3CCCNC3)c2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
330.00 | IC50 | CHEMBL1782520 | ChEMBL ↗ |
|
36793 ↗ |
O=C(O)c1cc2cc(Br)cc(NCC3CCNCC3)c2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
190.00 | IC50 | CHEMBL1782521 | ChEMBL ↗ |
|
36794 ↗ |
O=C(O)c1cc2cc(Br)cc(OCCC3CCNCC3)c2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
350.00 | IC50 | CHEMBL1782522 | ChEMBL ↗ |
|
36795 ↗ |
O=C(O)c1cc2cc(Br)cc(OCCc3ccncc3)c2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
21.10×103 | IC50 | CHEMBL1782523 | ChEMBL ↗ |
|
36796 ↗ |
O=C(O)c1cc2cc(Br)cc(NCCC3CCNCC3)c2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
540.00 | IC50 | CHEMBL1782524 | ChEMBL ↗ |
|
36797 ↗ |
O=C(O)c1cc2cc(Br)cc(NC(=O)C3CCNCC3)c2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
260.00 | IC50 | CHEMBL1782525 | ChEMBL ↗ |
|
36798 ↗ |
O=C(CC1CCNCC1)Nc1cc(Br)cc2cc(C(=O)O)oc12
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
340.00 | IC50 | CHEMBL1782526 | ChEMBL ↗ |
|
36799 ↗ |
O=C(O)c1cc2cc(Br)cc(OCC(=O)N3CCNCC3)c2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
1.30×103 | IC50 | CHEMBL1782527 | ChEMBL ↗ |
|
36800 ↗ |
O=C(O)c1cc2cc(Br)cc(C(=O)NC3CCNCC3)c2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
7.00×103 | IC50 | CHEMBL1782528 | ChEMBL ↗ |
|
36801 ↗ |
O=C(O)c1cc2cc(Br)cc(C(=O)NCC3CCNCC3)c2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
1.30×103 | IC50 | CHEMBL1782529 | ChEMBL ↗ |
|
36802 ↗ |
N[C@H]1CC[C@@H](Nc2cc(Br)cc3cc(C(=O)O)oc23)CC1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
4.00 | IC50 | CHEMBL1782530 | ChEMBL ↗ |
|
36803 ↗ |
N[C@H]1CC[C@H](Nc2cc(Br)cc3cc(C(=O)O)oc23)CC1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
66.00 | IC50 | CHEMBL1782531 | ChEMBL ↗ |
|
36804 ↗ |
O=C(O)c1cc2cc(Br)cc(N[C@H]3CC[C@@H](O)CC3)c2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
6.80×103 | IC50 | CHEMBL1782532 | ChEMBL ↗ |
|
36805 ↗ |
O=C(O)c1cc2cc(Br)cc(N[C@H]3CC[C@H](O)CC3)c2o1
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
6.10×103 | IC50 | CHEMBL1782533 | ChEMBL ↗ |
|
36806 ↗ |
Oc1c(Br)cc(C=C2c3cc(I)ccc3NC2O)cc1Br
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
70.00 | IC50 | CHEMBL1794051 | ChEMBL ↗ |
|
36836 ↗ |
CNC(=O)c1cccc2c1nc(Nc1c(F)cccc1F)c1ccncc12
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
2.00 | IC50 | CHEMBL1914471 | ChEMBL ↗ |
|
36837 ↗ |
COC(=O)c1cccc2c1nc(Nc1cccc(Cl)c1)c1ccncc12
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
894.00 | IC50 | CHEMBL1915420 | ChEMBL ↗ |
|
36838 ↗ |
NC(=O)c1cccc2c1nc(Nc1cccc(Cl)c1)c1ccncc12
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
54.00 | IC50 | CHEMBL1915421 | ChEMBL ↗ |
|
36839 ↗ |
CNC(=O)c1cccc2c1nc(Nc1cccc(Cl)c1)c1ccncc12
|
CHEMBL4523 ↗
UniProt: Q9P1W9 ↗ |
18.00 | IC50 | CHEMBL1915422 | ChEMBL ↗ |