CHEMBL4550 Ki
BioactivityChEMBL CHEMBL4550 Ki bioactivity data
1396 compounds · Target: Arachidonate 5-lipoxygenase-activating protein ( CHEMBL4550 ↗ ) · UniProt: P20292 ↗ · Ki
Arachidonate 5-lipoxygenase-activating protein, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
165940 ↗ |
Nc1cnc(-c2ccc(C3CCC3)c(Oc3ncccn3)c2F)cn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
10.50 | Ki | CHEMBL3586209 | ChEMBL ↗ |
|
165941 ↗ |
Nc1cnc(-c2ccc(C3CCC3)c(OCc3nc(C(=O)O)co3)c2F)cn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
29.40 | Ki | CHEMBL3639581 | ChEMBL ↗ |
|
165942 ↗ |
CCC(CC)(Cc1nc2ccc(OCc3ccn(C)n3)cc2n1Cc1ccc(OC(F)(F)F)c(F)c1)C(=O)O
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
45.00 | Ki | CHEMBL3639611 | ChEMBL ↗ |
|
165943 ↗ |
Cn1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4Br)c3c2)n1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
30.00 | Ki | CHEMBL3639658 | ChEMBL ↗ |
|
165944 ↗ |
O=C(O)[C@@H]1CCCC[C@H]1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Br)cc1F
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
12.00 | Ki | CHEMBL3639771 | ChEMBL ↗ |
|
165945 ↗ |
COc1ncc(-c2ccc(Cn3c(CC4(C(=O)O)CCCC4)nc4cc(OCc5ccc6ccccc6n5)ccc43)cc2)cc1C(F)(F)F
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
76.00 | Ki | CHEMBL3639772 | ChEMBL ↗ |
|
165946 ↗ |
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3ccccc3)cc2F)cn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
1.00 | Ki | CHEMBL3639872 | ChEMBL ↗ |
|
165947 ↗ |
CC(C)[C@@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
2.00 | Ki | CHEMBL3639873 | ChEMBL ↗ |
|
165948 ↗ |
Nc1ncc(-c2ccc(-c3ccc(C(F)(F)F)cc3S(=O)(=O)NCCO)cc2F)cn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
3.00 | Ki | CHEMBL3639919 | ChEMBL ↗ |
|
165949 ↗ |
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)c(F)c2)c(F)c1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
5.00 | Ki | CHEMBL3639920 | ChEMBL ↗ |
|
165950 ↗ |
Cc1ccnc(Oc2ccccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)n1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
12.00 | Ki | CHEMBL3639960 | ChEMBL ↗ |
|
165951 ↗ |
Nc1ccc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCOCC3)cc2F)cn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
83.30 | Ki | CHEMBL3639961 | ChEMBL ↗ |
|
165952 ↗ |
Nc1cnc(-c2ccc(-c3ccccc3CS(=O)(=O)c3ncccn3)cc2F)cn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
135.20 | Ki | CHEMBL3639996 | ChEMBL ↗ |
|
165953 ↗ |
Nc1cnc(-c2ccc(-c3ccccc3N3CCCCS3(=O)=O)cc2F)cn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
28.00 | Ki | CHEMBL3639997 | ChEMBL ↗ |
|
165954 ↗ |
Nc1cnc(-c2ccc(C3CCC3)c(O)c2F)cn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
354.00 | Ki | CHEMBL3640030 | ChEMBL ↗ |
|
165955 ↗ |
Nc1cnc(-c2ccc(C3CCC3)c(Oc3cccc(C(F)(F)F)n3)c2F)cn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
2.00 | Ki | CHEMBL3640031 | ChEMBL ↗ |
|
165956 ↗ |
CC(C)(C)c1ccc(-c2cnc(N)cn2)c(F)c1Oc1ncccn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
8.50 | Ki | CHEMBL3640032 | ChEMBL ↗ |
|
165957 ↗ |
CC(C)Oc1c(C2CCCC2)ccc(-c2cnc(N)cn2)c1F
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
92.10 | Ki | CHEMBL3659244 | ChEMBL ↗ |
|
165958 ↗ |
Fc1c(-c2cnc3[nH]ccc3n2)ccc(C2CCCC2)c1OCc1ccccc1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
30.80 | Ki | CHEMBL3659245 | ChEMBL ↗ |
|
165959 ↗ |
CC(C)(C)c1ccc(-c2cnc(N)cn2)cc1OCc1ccccc1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
620.00 | Ki | CHEMBL3659246 | ChEMBL ↗ |
|
165960 ↗ |
Nc1cnc(-c2ccc(Cl)c(OCc3ccccc3)c2F)cn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
866.00 | Ki | CHEMBL3659247 | ChEMBL ↗ |
|
165961 ↗ |
Nc1cnc(-c2ccc(C3CCC3)c(OCc3ccccc3)c2)cn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
1.25×103 | Ki | CHEMBL3659248 | ChEMBL ↗ |
|
165962 ↗ |
COc1c(C2CCC2)ccc(-c2cnc(N)c(C#N)n2)c1F
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
77.30 | Ki | CHEMBL3659249 | ChEMBL ↗ |
|
165963 ↗ |
Oc1c(C2CCC2)ccc(-c2cnc3[nH]ccc3c2)c1F
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
21.80 | Ki | CHEMBL3659251 | ChEMBL ↗ |
|
165964 ↗ |
Oc1c(C2CCC2)ccc(-c2cc3cc[nH]c3nn2)c1F
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
593.20 | Ki | CHEMBL3659252 | ChEMBL ↗ |
|
165965 ↗ |
N#Cc1nc(-c2ccc(C3CCC3)c(O)c2F)cnc1N
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
179.80 | Ki | CHEMBL3659253 | ChEMBL ↗ |
|
165966 ↗ |
Nc1cnc(-c2ccc(C3CCC3)c(Oc3ccnc(Oc4c(C5CCC5)ccc(-c5cnc(N)cn5)c4F)n3)c2F)cn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
23.20 | Ki | CHEMBL3659255 | ChEMBL ↗ |
|
165967 ↗ |
Fc1c(-c2cnc3c(c2)OCCN3)ccc(C2CCC2)c1Oc1ncccn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
2.50 | Ki | CHEMBL3659256 | ChEMBL ↗ |
|
165968 ↗ |
Nc1ccnc(Oc2c(C3CCC3)ccc(-c3cnc4c(c3)OCCN4)c2F)n1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
1.40 | Ki | CHEMBL3659257 | ChEMBL ↗ |
|
165969 ↗ |
COc1cc(Oc2c(C3CCC3)ccc(-c3cnc4c(c3)OCCN4)c2F)ncn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
8.50 | Ki | CHEMBL3659258 | ChEMBL ↗ |
|
165970 ↗ |
COc1cc(Oc2c(C3CCC3)ccc(-c3cnc4[nH]ccc4c3)c2F)ncn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
24.40 | Ki | CHEMBL3659259 | ChEMBL ↗ |
|
165971 ↗ |
COc1cc(Oc2c(C3CCC3)ccc(-c3cnc4[nH]ccc4n3)c2F)ncn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
7.70 | Ki | CHEMBL3659260 | ChEMBL ↗ |
|
165972 ↗ |
Fc1c(-c2cnc3[nH]ccc3n2)ccc(C2CCC2)c1Oc1ncccn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
2.50 | Ki | CHEMBL3659261 | ChEMBL ↗ |
|
165973 ↗ |
Nc1ccc(-c2ccc(C3CCC3)c(Oc3ncccn3)c2F)nn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
2.14×103 | Ki | CHEMBL3659262 | ChEMBL ↗ |
|
165974 ↗ |
COc1cc(Oc2c(C3CCC3)ccc(-c3ccc(N)nn3)c2F)ncn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
1.59×103 | Ki | CHEMBL3659263 | ChEMBL ↗ |
|
165975 ↗ |
Nc1ccc(-c2ccc(C3CCC3)c(Oc3cc(O)ncn3)c2F)nn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
1.68×103 | Ki | CHEMBL3659264 | ChEMBL ↗ |
|
165976 ↗ |
N#Cc1nccc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)n1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
1.30×103 | Ki | CHEMBL3659265 | ChEMBL ↗ |
|
165977 ↗ |
Cc1nc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)cc(N(C)C)n1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
3.30 | Ki | CHEMBL3659266 | ChEMBL ↗ |
|
165978 ↗ |
Cc1cc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)nc(N(C)C)n1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
2.20 | Ki | CHEMBL3659267 | ChEMBL ↗ |
|
165979 ↗ |
CN(C)c1cc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)ncn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
3.30 | Ki | CHEMBL3659268 | ChEMBL ↗ |
|
165980 ↗ |
CCc1c(C(F)(F)F)nn(C)c1Oc1c(C2CCC2)ccc(-c2cnc(N)cn2)c1F
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
155.10 | Ki | CHEMBL3659269 | ChEMBL ↗ |
|
165981 ↗ |
CS(=O)(=O)c1ccc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)nc1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
8.30 | Ki | CHEMBL3659270 | ChEMBL ↗ |
|
165982 ↗ |
CC(C)(C)c1cc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)nc(N)n1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
23.60 | Ki | CHEMBL3659271 | ChEMBL ↗ |
|
165983 ↗ |
Nc1cnc(-c2ccc(C3CCC3)c(Oc3nccc(N4CCC5(CC4)OCCCO5)n3)c2F)cn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
1.20 | Ki | CHEMBL3659272 | ChEMBL ↗ |
|
165984 ↗ |
CC(C)Cc1cc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)nc(N)n1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
3.60 | Ki | CHEMBL3659273 | ChEMBL ↗ |
|
165985 ↗ |
COc1c(C2CCC2)ccc(-c2cnc3[nH]ccc3c2)c1F
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
90.00 | Ki | CHEMBL3659274 | ChEMBL ↗ |
|
165986 ↗ |
CS(=O)(=O)NCCOc1c(C2CCC2)ccc(-c2cnc(N)cn2)c1F
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
235.50 | Ki | CHEMBL3659275 | ChEMBL ↗ |
|
165987 ↗ |
Nc1cnc(-c2ccc(C3CCC3)c(OCCN3CCOCC3)c2F)cn1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
462.20 | Ki | CHEMBL3659276 | ChEMBL ↗ |
|
165988 ↗ |
CCOC(=O)CCCOc1c(C2CCC2)ccc(-c2cnc(N)cn2)c1F
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
62.20 | Ki | CHEMBL3659277 | ChEMBL ↗ |
|
165989 ↗ |
CC(C)(C)OC(=O)N1CC(COc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)C1
|
CHEMBL4550 ↗
UniProt: P20292 ↗ |
98.60 | Ki | CHEMBL3659278 | ChEMBL ↗ |