CHEMBL4685 IC50
BioactivityChEMBL CHEMBL4685 IC50 bioactivity data
1667 compounds · Target: Indoleamine 2,3-dioxygenase 1 ( CHEMBL4685 ↗ ) · UniProt: P14902 ↗ · IC50
Indoleamine 2,3-dioxygenase 1, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
6594 ↗ |
O=C(NO)c1ccccc1
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
16.00×103 | IC50 | CHEMBL16300 | ChEMBL ↗ |
|
7335 ↗ |
Nc1ccccc1NC(=O)c1ccc(C(=O)NCCNc2nonc2/C(=N/O)Nc2ccc(F)c(Br)c2)cc1
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
69.00 | IC50 | CHEMBL4291940 | ChEMBL ↗ |
|
14162 ↗ |
NNCCc1ccccc1
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
14.00×103 | IC50 | CHEMBL1089 | ChEMBL ↗ |
|
14647 ↗ |
Nc1c(C(=O)O)c2nc3c(C(=O)O)cccc3oc-2cc1=O
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
460.00 | IC50 | CHEMBL2322655 | ChEMBL ↗ |
|
15671 ↗ |
O=C(NNC(=S)Nc1ccc(Cl)c(Cl)c1)c1ccccc1O
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
37.00×103 | IC50 | CHEMBL4476621 | ChEMBL ↗ |
|
20766 ↗ |
Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
3.35×103 | IC50 | CHEMBL91 | ChEMBL ↗ |
|
46955 ↗ |
O=C1C=CC(=O)c2c(O)cccc21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
1.00×103 | IC50 | CHEMBL43612 | ChEMBL ↗ |
|
66607 ↗ |
CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
28.50×103 | IC50 | CHEMBL157101 | ChEMBL ↗ |
|
70590 ↗ |
O=S1(=O)CCCN1CCNc1nonc1/C(=N/O)Nc1ccc(F)c(Br)c1
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
33.95 | IC50 | CHEMBL4451860 | ChEMBL ↗ |
|
70991 ↗ |
CCCNC(=O)C1(c2ccc(NC(=O)c3cccc(Cl)c3)cc2)CCC1
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
9.27 | IC50 | CHEMBL4636709 | ChEMBL ↗ |
|
71180 ↗ |
C[C@@H](NC(=O)c1ccc(Cl)cc1)c1ccc2c(c1)OCCN2C(=O)c1cccc(Cl)c1
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
3.00 | IC50 | CHEMBL4744926 | ChEMBL ↗ |
|
71194 ↗ |
Cc1cc(N2CCCc3nc([C@@H](C)NC(=O)c4ccc(F)cc4)ccc32)ccn1
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
89.00 | IC50 | CHEMBL4747474 | ChEMBL ↗ |
|
71196 ↗ |
COC(=O)N1CCCc2nc([C@@H](C)NC(=O)c3ccc(F)cc3)ccc21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
22.00 | IC50 | CHEMBL4747995 | ChEMBL ↗ |
|
71199 ↗ |
CC(C)CC(=O)N1CCCc2cc(CNC(=O)c3ccc(Cl)cc3)ccc21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
16.00 | IC50 | CHEMBL4748177 | ChEMBL ↗ |
|
71212 ↗ |
C[C@@H](NC(=O)c1ccc(F)cc1)c1ccc2c(n1)CCCN2c1ncccn1
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
24.00 | IC50 | CHEMBL4750629 | ChEMBL ↗ |
|
71248 ↗ |
C[C@@H](NC(=O)c1ccc(Cl)cc1)c1ccc2c(n1)CCCN2C(=O)c1cccc(Cl)c1
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
1.60 | IC50 | CHEMBL4755227 | ChEMBL ↗ |
|
71310 ↗ |
C[C@@H](NC(=O)c1ccc(F)cc1)c1ccc2c(n1)CCCN2C(=O)OC1CCC1
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
800.00×10-3 | IC50 | CHEMBL4764710 | ChEMBL ↗ |
|
71335 ↗ |
C[C@@H](NC(=O)c1ccc(Cl)cc1)c1cc2c(cn1)N(C(=O)c1cccc(Cl)c1)CCC2
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
7.80 | IC50 | CHEMBL4777831 | ChEMBL ↗ |
|
71351 ↗ |
C[C@@H](NC(=O)c1ccc(F)cc1)c1ccc2c(n1)CCCN2c1ccncn1
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
1.70 | IC50 | CHEMBL4779920 | ChEMBL ↗ |
|
71404 ↗ |
C[C@H](NC(=O)c1ccc(Cl)cc1)c1ccc2c(c1)CCCN2C(=O)c1cccc(Cl)c1
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
25.00 | IC50 | CHEMBL4788204 | ChEMBL ↗ |
|
71407 ↗ |
CCOC(=O)N1CCCc2nc([C@@H](C)NC(=O)c3ccc(F)cc3)ccc21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
3.00 | IC50 | CHEMBL4788473 | ChEMBL ↗ |
|
71423 ↗ |
O=C(NCc1ccc2c(c1)CCCN2C(=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
9.00 | IC50 | CHEMBL4791214 | ChEMBL ↗ |
|
71469 ↗ |
C[C@@H](NC(=O)c1ccc(Cl)cc1)c1ccc2c(c1)CCCN2C(=O)c1cccc(Cl)c1
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
5.00 | IC50 | CHEMBL4799004 | ChEMBL ↗ |
|
71498 ↗ |
O=C(N[C@H](C1CC1)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(F)c(F)cc43)C[C@@H]21)c1ccc(Cl)cc1
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
3.60 | IC50 | CHEMBL4846356 | ChEMBL ↗ |
|
71500 ↗ |
C[C@@H](NC(=O)c1ccc(C#N)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(F)c(F)cc43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
33.00 | IC50 | CHEMBL4846783 | ChEMBL ↗ |
|
71507 ↗ |
CC[C@@H](NC(=O)c1ccc(OC)nc1)[C@H]1CC[C@@H](c2ccnc(OC)c2C(F)F)CC1
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
2.15 | IC50 | CHEMBL4848094 | ChEMBL ↗ |
|
71510 ↗ |
CC[C@@H](NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4ccc(C#N)cc43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
8.80 | IC50 | CHEMBL4848514 | ChEMBL ↗ |
|
71513 ↗ |
C[C@@H](NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(F)c(F)cc43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
5.30 | IC50 | CHEMBL4849414 | ChEMBL ↗ |
|
71515 ↗ |
CCC(c1nc2cc(Cl)ccc2[nH]1)[C@H]1[C@@H]2C[C@@H](c3ccnc4ccc(F)cc34)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
920.00×10-3 | IC50 | CHEMBL4849690 | ChEMBL ↗ |
|
71533 ↗ |
CCC(NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(F)cc(F)c43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
6.20 | IC50 | CHEMBL4852566 | ChEMBL ↗ |
|
71535 ↗ |
CCC(NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4ncc(C#N)cc43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
357.00 | IC50 | CHEMBL4853456 | ChEMBL ↗ |
|
71536 ↗ |
CC[C@@H](NC(=O)c1ccc(C#N)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(F)c(F)cc43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
4.40 | IC50 | CHEMBL4853672 | ChEMBL ↗ |
|
71552 ↗ |
CCC(NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4ccc(F)c(F)c43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
4.00 | IC50 | CHEMBL4856417 | ChEMBL ↗ |
|
71558 ↗ |
CCC(NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(F)c(F)cc43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
4.60 | IC50 | CHEMBL4858219 | ChEMBL ↗ |
|
71561 ↗ |
CC[C@@H](NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4ccc(F)cc43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
2.50 | IC50 | CHEMBL4859064 | ChEMBL ↗ |
|
71563 ↗ |
CC[C@@H](NC(=O)C12CC(F)(C1)C2)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(F)c(F)cc43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
426.00 | IC50 | CHEMBL4859674 | ChEMBL ↗ |
|
71572 ↗ |
CCC(NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(F)cnc43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
19.00 | IC50 | CHEMBL4861936 | ChEMBL ↗ |
|
71575 ↗ |
CCC(NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(Cl)c(Cl)cc43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
12.00 | IC50 | CHEMBL4862584 | ChEMBL ↗ |
|
71577 ↗ |
O=C(NC[C@@H]1[C@H]2C[C@H](n3cnc4cc(F)c(F)cc43)C[C@@H]12)c1ccc(Cl)cc1
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
19.00 | IC50 | CHEMBL4862755 | ChEMBL ↗ |
|
71578 ↗ |
CC[C@@H](NC(=O)c1ccc(C#N)cc1)[C@@H]1[C@@H]2C[C@@H](n3cnc4ccc(C#N)cc43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
35.00 | IC50 | CHEMBL4863103 | ChEMBL ↗ |
|
71579 ↗ |
CC[C@@H](NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4ccc(Cl)cc43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
3.40 | IC50 | CHEMBL4863359 | ChEMBL ↗ |
|
71586 ↗ |
CCC(NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4ccncc43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
30.00 | IC50 | CHEMBL4865106 | ChEMBL ↗ |
|
71590 ↗ |
CCC(NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(F)ccc43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
2.60 | IC50 | CHEMBL4866113 | ChEMBL ↗ |
|
71593 ↗ |
CCC(NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4cccc(F)c43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
5.20 | IC50 | CHEMBL4866916 | ChEMBL ↗ |
|
71594 ↗ |
CCC(NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4ccc(F)cc43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
2.60 | IC50 | CHEMBL4866976 | ChEMBL ↗ |
|
71602 ↗ |
CC[C@@H](NC(=O)c1ccc(Cl)c(F)c1)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(F)c(F)cc43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
3.90 | IC50 | CHEMBL4869547 | ChEMBL ↗ |
|
71607 ↗ |
CCC(NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4cc(C#N)ccc43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
73.00 | IC50 | CHEMBL4870583 | ChEMBL ↗ |
|
71615 ↗ |
CC[C@H](NC(=O)c1ccc(Cl)cc1)[C@@H]1[C@@H]2C[C@@H](n3cnc4ccc(F)cc43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
8.40 | IC50 | CHEMBL4871068 | ChEMBL ↗ |
|
71617 ↗ |
CCC(NC(=O)c1ccc(Cl)cc1)[C@H]1[C@@H]2C[C@@H](n3cnc4c(F)cc(F)cc43)C[C@@H]21
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
7.00 | IC50 | CHEMBL4872039 | ChEMBL ↗ |
|
71629 ↗ |
Fc1cc2ncn([C@H]3C[C@@H]4[C@@H](CNC(c5ccc(Cl)cc5)C(F)(F)F)[C@@H]4C3)c2cc1F
|
CHEMBL4685 ↗
UniProt: P14902 ↗ |
520.00×10-3 | IC50 | CHEMBL4873747 | ChEMBL ↗ |