CHEMBL4722 IC50
BioactivityChEMBL CHEMBL4722 IC50 bioactivity data
1709 compounds · Target: Aurora kinase A ( CHEMBL4722 ↗ ) · UniProt: O14965 ↗ · IC50
Aurora kinase A, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
2382 ↗ |
CCC(=O)N1CCN(S(=O)(=O)c2cccc(Nc3ncc4c(n3)N(C)c3ccc(C)cc3C(=O)N4C)c2)CC1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
110.00 | IC50 | CHEMBL3942643 | ChEMBL ↗ |
|
2384 ↗ |
Cc1ccc2c(c1)C(=O)N(C)c1cnc(Nc3cccc(S(=O)(=O)N4CCC(O)CC4)c3)nc1N2C
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
150.00 | IC50 | CHEMBL3959351 | ChEMBL ↗ |
|
2390 ↗ |
C=CC(=O)Nc1ccc(C(=O)Nc2ccc(Nc3ncc4c(n3)N(C)c3ccc(C)cc3C(=O)N4C)cc2)cc1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
44.00 | IC50 | CHEMBL3969370 | ChEMBL ↗ |
|
2394 ↗ |
C=CC(=O)N1CCN(S(=O)(=O)c2cccc(Nc3ncc4c(n3)N(C)c3ccc(C)cc3C(=O)N4C)c2)CC1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
59.00 | IC50 | CHEMBL3979343 | ChEMBL ↗ |
|
2803 ↗ |
CCC(=O)Nc1ccc(C(=O)Nc2ccc(Nc3ncc4c(n3)N(C)c3ccc(C)cc3C(=O)N4C)cc2)cc1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
52.00 | IC50 | CHEMBL4206831 | ChEMBL ↗ |
|
5372 ↗ |
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
3.80×103 | IC50 | CHEMBL1336 | ChEMBL ↗ |
|
5528 ↗ |
COc1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)cc(OC)c1OC
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
7.65×103 | IC50 | CHEMBL201511 | ChEMBL ↗ |
|
5671 ↗ |
O=C(NCCc1ccc(O)c(Br)c1)/C(Cc1cc(Br)c(O)c(Oc2ccc(CCNC(=O)/C(Cc3cc(Br)c(O)c(-c4cc(C/C(=N\O)C(=O)NCCc5ccc(O)c(Br)c5)cc(Br)c4O)c3)=N/O)cc2Br)c1)=N/O
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
2.60×103 | IC50 | CHEMBL2333163 | ChEMBL ↗ |
|
5672 ↗ |
O=C1NCCc2ccc(O)c(c2)Oc2c(Br)cc(cc2Br)CCNC(=O)/C(=N/O)Cc2cc(Br)c(O)c(c2)Oc2c(Br)cc(cc2Br)C/C1=N\O
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
1.30×103 | IC50 | CHEMBL2333164 | ChEMBL ↗ |
|
5780 ↗ |
Oc1cccc(Nc2ccnc3[nH]c4ccccc4c23)c1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
250.00 | IC50 | CHEMBL3133821 | ChEMBL ↗ |
|
5846 ↗ |
O=C1N/C=C/c2ccc(c(Br)c2)Oc2cc(cc(Br)c2O)CCNC(=O)/C(=N/O)Cc2ccc(c(Br)c2)Oc2cc(cc(Br)c2O)C/C1=N\O
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
3.90×103 | IC50 | CHEMBL360190 | ChEMBL ↗ |
|
6320 ↗ |
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
4.00 | IC50 | CHEMBL458997 | ChEMBL ↗ |
|
6391 ↗ |
COc1cc(C2=C(c3cn(COC(C)(C)C)c4ccccc34)CNC2=O)cc(OC)c1OC
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
30.00×103 | IC50 | CHEMBL488646 | ChEMBL ↗ |
|
6392 ↗ |
COc1cc(C2=C(c3cn(COc4ccccc4)c4ccccc34)CNC2=O)cc(OC)c1OC
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
6.50×103 | IC50 | CHEMBL488811 | ChEMBL ↗ |
|
6407 ↗ |
O=C(NCCc1ccc(O)c(Br)c1)/C(Cc1cc(Br)c(O)c(-c2cc(C/C(=N/O)C(=O)NCCc3ccc(O)c(Br)c3)cc(Br)c2O)c1)=N\O
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
100.00 | IC50 | CHEMBL505637 | ChEMBL ↗ |
|
6408 ↗ |
O=C1NCCc2cc(Br)c(O)c(c2)Oc2c(Br)cc(cc2Br)CCNC(=O)/C(=N/O)Cc2cc(Br)c(O)c(c2)Oc2c(Br)cc(cc2Br)C/C1=N\O
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
1.70×103 | IC50 | CHEMBL510730 | ChEMBL ↗ |
|
6570 ↗ |
O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
2.48×103 | IC50 | CHEMBL6246 | ChEMBL ↗ |
|
15948 ↗ |
O=C1/C(=C/c2ccc(O)c(O)c2)Oc2cc(O)ccc21
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
850.00 | IC50 | CHEMBL490355 | ChEMBL ↗ |
|
16281 ↗ |
CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)c(NC3CCOCC3)c2)CC1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
215.00 | IC50 | CHEMBL1983268 | ChEMBL ↗ |
|
16283 ↗ |
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
472.00 | IC50 | CHEMBL2006765 | ChEMBL ↗ |
|
16385 ↗ |
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ccc6c5)c4c3)cc2)CC1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
108.00 | IC50 | CHEMBL2436978 | ChEMBL ↗ |
|
16465 ↗ |
O=C1/C(=C\c2ccc(O)c(O)c2)Oc2ccccc21
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
1.34×103 | IC50 | CHEMBL3361128 | ChEMBL ↗ |
|
16520 ↗ |
CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
3.10 | IC50 | CHEMBL3545085 | ChEMBL ↗ |
|
16996 ↗ |
CNc1ncnc(-c2cccnc2Oc2ccc(F)c(C(=O)Nc3cc(C(F)(F)F)ccc3N(C)CCCN(C)C)c2)n1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
25.00×103 | IC50 | CHEMBL373882 | ChEMBL ↗ |
|
17017 ↗ |
Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
3.10×103 | IC50 | CHEMBL3787112 | ChEMBL ↗ |
|
17541 ↗ |
CC1(C)OCC(=O)Nc2cc(Nc3nc(NCC(F)(F)F)c4occc4n3)ccc21
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
4.05×103 | IC50 | CHEMBL4069365 | ChEMBL ↗ |
|
17609 ↗ |
CCc1cc(Nc2nc(N[C@@H](C)c3ccc(Cl)cn3)nc3cccc(OC)c23)n[nH]1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
22.00×103 | IC50 | CHEMBL4852125 | ChEMBL ↗ |
|
17610 ↗ |
CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)nc3cccc(OC)c23)n[nH]1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
860.00 | IC50 | CHEMBL4854871 | ChEMBL ↗ |
|
17612 ↗ |
CCc1cc(Nc2nc(NCc3ccc(Cl)cc3OC)nc3cccc(C)c23)n[nH]1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
1.20×103 | IC50 | CHEMBL4860332 | ChEMBL ↗ |
|
17615 ↗ |
CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)nc3cccc(C)c23)n[nH]1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
330.00 | IC50 | CHEMBL4875929 | ChEMBL ↗ |
|
17616 ↗ |
CCc1cc(Nc2nc(NCc3ccc(Cl)cc3OC)nc3cccc(OC)c23)n[nH]1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
8.90×103 | IC50 | CHEMBL4877302 | ChEMBL ↗ |
|
17628 ↗ |
Cn1ccc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2c1=O
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
36.62 | IC50 | CHEMBL5089164 | ChEMBL ↗ |
|
17630 ↗ |
CN(C)C(=O)c1ccc(Nc2ncc(C(F)(F)F)c(N[C@H]3CC[C@@H](N)CC3)n2)cc1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
56.38 | IC50 | CHEMBL5092606 | ChEMBL ↗ |
|
17639 ↗ |
COc1cc(C2=C(c3c[nH]c4ccccc34)CNC2=O)cc(OC)c1OC
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
16.00×103 | IC50 | CHEMBL529663 | ChEMBL ↗ |
|
17695 ↗ |
CN1CCN(c2ccc(C(=O)Nc3cc(-c4cccc(NS(=O)(=O)c5ccccc5)c4)n[nH]3)cc2)CC1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
340.00 | IC50 | CHEMBL1807392 | ChEMBL ↗ |
|
17697 ↗ |
CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(-c4cnn(C)c4)cc3c(=O)c2c1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
290.00 | IC50 | CHEMBL1822792 | ChEMBL ↗ |
|
17720 ↗ |
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cn[nH]c5)cnc(N)c34)cc2)c1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
357.20 | IC50 | CHEMBL1969102 | ChEMBL ↗ |
|
17725 ↗ |
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)(C)O)c5)cnc(N)c34)cc2)cc1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
3.62×103 | IC50 | CHEMBL2004290 | ChEMBL ↗ |
|
17726 ↗ |
CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
42.00 | IC50 | CHEMBL2010872 | ChEMBL ↗ |
|
17730 ↗ |
Cc1ccc(NC(=O)Nc2nnc(Sc3ncnc4cc(OCCCN5CCOCC5)ccc34)s2)cc1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
1.50×103 | IC50 | CHEMBL2046883 | ChEMBL ↗ |
|
17738 ↗ |
CN1CCN(c2ccc(C(=O)Nc3cc(-c4ccc(CNC(=O)OCc5ccccc5)cc4)n[nH]3)cc2)CC1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
880.00 | IC50 | CHEMBL2063323 | ChEMBL ↗ |
|
17740 ↗ |
O=C(NCc1ccc(-c2cc(NC(=O)c3ccc(OCCN4CCOCC4)cc3)[nH]n2)cc1)OCc1ccccc1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
590.00 | IC50 | CHEMBL2063326 | ChEMBL ↗ |
|
17748 ↗ |
CN1CCN(c2ccc(C(=O)Nc3cc(-c4ccc(CNS(=O)(=O)c5ccccc5)cc4)n[nH]3)cc2)CC1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
1.00×103 | IC50 | CHEMBL2063334 | ChEMBL ↗ |
|
17749 ↗ |
Cc1nc(Nc2cc(-c3ccc(CNC(=O)OCc4ccccc4)cc3)n[nH]2)cc(N2CCN(C)CC2)n1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
430.00 | IC50 | CHEMBL2063335 | ChEMBL ↗ |
|
17752 ↗ |
Cc1nc(Nc2cc(-c3ccc(CNC(=O)OCc4ccccc4)cc3)n[nH]2)cc(N2CCN(CCO)CC2)n1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
170.00 | IC50 | CHEMBL2063338 | ChEMBL ↗ |
|
17755 ↗ |
Cc1nc(Nc2cc(-c3ccc(CNC(=O)OCc4ccccc4)cc3)n[nH]2)cc(N2CCNCC2)n1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
350.00 | IC50 | CHEMBL2063436 | ChEMBL ↗ |
|
17760 ↗ |
Cn1cc(Nc2ncc(Br)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)cn1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
3.00 | IC50 | CHEMBL2071201 | ChEMBL ↗ |
|
17807 ↗ |
CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
1.39×103 | IC50 | CHEMBL215152 | ChEMBL ↗ |
|
17835 ↗ |
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
760.00 | IC50 | CHEMBL223360 | ChEMBL ↗ |
|
17851 ↗ |
c1cc2c(ncc3cnc(C4CCCCC4)n32)[nH]1
|
CHEMBL4722 ↗
UniProt: O14965 ↗ |
270.00 | IC50 | CHEMBL2322134 | ChEMBL ↗ |