CHEMBL4792 Ki
BioactivityChEMBL CHEMBL4792 Ki bioactivity data
1494 compounds · Target: Orexin receptor type 2 ( CHEMBL4792 ↗ ) · UniProt: O43614 ↗ · Ki
Orexin receptor type 2, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
34507 ↗ |
COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
70.00×10-3 | Ki | CHEMBL3099899 | ChEMBL ↗ |
|
42407 ↗ |
COc1ccccc1OCCNC[C@@H](O)COc1cccc2[nH]c3ccccc3c12
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
1.40×103 | Ki | CHEMBL3798017 | ChEMBL ↗ |
|
65580 ↗ |
COc1c(F)cccc1C(=O)N1C[C@@H](C)CC[C@H]1CNc1ccc(Br)cn1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
63.10 | Ki | CHEMBL2413522 | ChEMBL ↗ |
|
69207 ↗ |
Cc1ncc(OC[C@@]2(c3ccccc3)C[C@H]2C(=O)Nc2ccc(F)cn2)c(C)n1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
7.00 | Ki | CHEMBL3585946 | ChEMBL ↗ |
|
69208 ↗ |
Cc1ncc(OC[C@@]2(c3ccccc3F)C[C@H]2C(=O)Nc2ccc(F)cn2)c(C)n1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
17.00 | Ki | CHEMBL3585953 | ChEMBL ↗ |
|
69209 ↗ |
Cc1ncc(OC[C@@]2(c3ccc(F)cc3)C[C@H]2C(=O)Nc2ccc(F)cn2)c(C)n1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
8.00 | Ki | CHEMBL3585954 | ChEMBL ↗ |
|
69210 ↗ |
Cc1ncc(OC[C@@]2(c3cc(F)cc(F)c3)C[C@H]2C(=O)Nc2ccc(F)cn2)c(C)n1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
3.00 | Ki | CHEMBL3585955 | ChEMBL ↗ |
|
69211 ↗ |
Cc1ncc(OC[C@@]2(c3ccc(F)c(F)c3)C[C@H]2C(=O)Nc2ccc(F)cn2)c(C)n1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
4.00 | Ki | CHEMBL3585956 | ChEMBL ↗ |
|
69213 ↗ |
Cc1cc(C)nc(N2C[C@H]3CN(C(=O)c4cccc(F)c4-n4nccn4)C[C@H]3C2)n1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
14.00 | Ki | CHEMBL3586433 | ChEMBL ↗ |
|
69214 ↗ |
Cc1cc(C)nc(N2C[C@H]3CN(C(=O)c4c(C)cccc4-n4nccn4)C[C@H]3C2)n1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
8.00 | Ki | CHEMBL3586440 | ChEMBL ↗ |
|
69215 ↗ |
COc1ccc(-n2nccn2)c(C(=O)N2C[C@@H]3CN(c4nc(C)cc(C)n4)C[C@@H]3C2)c1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
46.00 | Ki | CHEMBL3586441 | ChEMBL ↗ |
|
169800 ↗ |
C[C@H]1CCN(c2ncc3ccccc3n2)CCN1C(=O)c1ccccc1-n1nccn1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
8.50 | Ki | CHEMBL1082414 | ChEMBL ↗ |
|
169801 ↗ |
C[C@@H]1CCN(c2cnc3cc(F)c(F)cc3n2)CCN1C(=O)c1ccccc1-n1nccn1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
250.00×10-3 | Ki | CHEMBL1083041 | ChEMBL ↗ |
|
169802 ↗ |
Cc1ccc(-n2nccn2)c(C(=O)N2CCN(c3ncc4ccccc4n3)CC[C@H]2C)c1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
360.00×10-3 | Ki | CHEMBL1083357 | ChEMBL ↗ |
|
169803 ↗ |
C[C@@H]1CCN(c2ncc3c(n2)CCCC3)CCN1C(=O)c1ccccc1-n1nccn1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
280.00×10-3 | Ki | CHEMBL1083657 | ChEMBL ↗ |
|
169804 ↗ |
Cc1ccc(-n2nccn2)c(C(=O)N2CCN(c3nc4ccccc4o3)CC[C@H]2C)c1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
3.20 | Ki | CHEMBL1083658 | ChEMBL ↗ |
|
169805 ↗ |
C[C@@H]1CCN(c2ncc3ccccc3n2)CCN1C(=O)c1ccccc1-n1nccn1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
470.00×10-3 | Ki | CHEMBL1084949 | ChEMBL ↗ |
|
169806 ↗ |
Cc1cc(NC(=O)Nc2ccc(N(C)C)cc2)c2cc(F)cc(F)c2n1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
1.10×103 | Ki | CHEMBL1334465 | ChEMBL ↗ |
|
169807 ↗ |
COc1ccc(CCNC(=O)Cn2c(-c3nonc3N)nc3ccccc32)cc1OC
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
800.00 | Ki | CHEMBL1481561 | ChEMBL ↗ |
|
169808 ↗ |
CC1(C)OC[C@H](NC(=O)Nc2ccccc2-c2cccnc2)[C@H](c2ccccc2)O1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
316.23 | Ki | CHEMBL182269 | ChEMBL ↗ |
|
169809 ↗ |
Cc1ccc(Cl)c(NC(=O)N[C@H]2COC(C)(C)O[C@H]2c2ccccc2)c1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
63.10 | Ki | CHEMBL182473 | ChEMBL ↗ |
|
169810 ↗ |
CC1(C)OC[C@H](NC(=O)Nc2ccccc2-c2ccccc2)[C@H](c2ccccc2)O1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
100.00 | Ki | CHEMBL183421 | ChEMBL ↗ |
|
169811 ↗ |
Cc1ccc(NC(=O)N[C@H]2COC(C)(C)O[C@H]2c2ccccc2)c(C)c1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
125.89 | Ki | CHEMBL183576 | ChEMBL ↗ |
|
169812 ↗ |
CC1(C)OC[C@H](/N=C(\S)Nc2ccc(Cl)cc2Cl)[C@H](c2ccccc2)O1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
199.53 | Ki | CHEMBL183734 | ChEMBL ↗ |
|
169813 ↗ |
CC(C)c1ccccc1NC(=O)N[C@H]1COC(C)(C)O[C@H]1c1ccccc1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
2.51×103 | Ki | CHEMBL183786 | ChEMBL ↗ |
|
169814 ↗ |
CC1(C)OC[C@H](/N=C(\S)Nc2ccccc2Br)[C@H](c2ccccc2)O1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
398.11 | Ki | CHEMBL184303 | ChEMBL ↗ |
|
169815 ↗ |
COc1ccccc1NC(=O)N[C@H]1COC(C)(C)O[C@H]1c1ccccc1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
2.51×103 | Ki | CHEMBL184384 | ChEMBL ↗ |
|
169816 ↗ |
CC1(C)OC[C@H](NC(=O)Nc2ccccc2-c2ccsc2)[C@H](c2ccccc2)O1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
79.43 | Ki | CHEMBL184596 | ChEMBL ↗ |
|
169817 ↗ |
CC1(C)OC[C@H](NC(=O)Nc2ccc(Br)cc2)[C@H](c2ccccc2)O1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
251.19 | Ki | CHEMBL184936 | ChEMBL ↗ |
|
169818 ↗ |
Cc1ccc(/N=C(\NC#N)N[C@H]2COC(C)(C)O[C@H]2c2ccccc2)c(Br)c1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
1.26×103 | Ki | CHEMBL185005 | ChEMBL ↗ |
|
169819 ↗ |
CC1(C)OC[C@H](NC(=O)Nc2cccc(Br)c2)[C@H](c2ccccc2)O1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
1.00×103 | Ki | CHEMBL185080 | ChEMBL ↗ |
|
169820 ↗ |
CC1(C)OC[C@H](NC(=O)Nc2ccc(Br)cc2Cl)[C@H](c2ccccc2)O1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
6.31 | Ki | CHEMBL185088 | ChEMBL ↗ |
|
169821 ↗ |
Cc1cc(Br)ccc1NC(=O)N[C@H]1COC(C)(C)O[C@H]1c1ccccc1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
39.81 | Ki | CHEMBL185093 | ChEMBL ↗ |
|
169822 ↗ |
CC1(C)OC[C@H](NC(=O)Nc2ccccc2-c2cccc(Cl)c2)[C@H](c2ccccc2)O1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
79.43 | Ki | CHEMBL185131 | ChEMBL ↗ |
|
169823 ↗ |
CC1(C)OC[C@H](NC(=O)Nc2ccc(Cl)cc2Cl)[C@H](c2ccccc2)O1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
19.95 | Ki | CHEMBL185136 | ChEMBL ↗ |
|
169824 ↗ |
CC1(C)OC[C@H](NC(=O)c2ccc(Cl)cc2Cl)[C@H](c2ccccc2)O1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
199.53 | Ki | CHEMBL185324 | ChEMBL ↗ |
|
169825 ↗ |
CC1(C)OC[C@H](NC(=O)Nc2ccccc2I)[C@H](c2ccccc2)O1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
79.43 | Ki | CHEMBL185382 | ChEMBL ↗ |
|
169826 ↗ |
CC1(C)OC[C@H](NC(=O)Nc2ccccc2-c2cccs2)[C@H](c2ccccc2)O1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
50.12 | Ki | CHEMBL185424 | ChEMBL ↗ |
|
169827 ↗ |
CC1(C)OC[C@H](NC(=O)Nc2ccccc2Cl)[C@H](c2ccccc2)O1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
79.43 | Ki | CHEMBL185435 | ChEMBL ↗ |
|
169828 ↗ |
Cc1ccc(-c2ncccn2)c(C(=O)N2C[C@H](COc3ccc(F)cn3)CC[C@H]2C)c1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
249.75×10-3 | Ki | CHEMBL2107822 | ChEMBL ↗ |
|
169829 ↗ |
Cc1nc(C(=O)N2CCC[C@H]2Cc2nnc(-c3ccccc3)o2)c(-c2ccccc2F)s1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
129.00 | Ki | CHEMBL2110363 | ChEMBL ↗ |
|
169830 ↗ |
[3H]c1ccc(CN(CC)C(=O)CN(c2ccc(OC([3H])([3H])[3H])nc2)S(=O)(=O)c2ccccc2C)cn1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
1.10 | Ki | CHEMBL2385133 | ChEMBL ↗ |
|
169831 ↗ |
CCN(Cc1cccnc1)C(=O)CN(c1ccc(O[11CH3])nc1)S(=O)(=O)c1ccccc1C
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
1.10 | Ki | CHEMBL2385134 | ChEMBL ↗ |
|
169832 ↗ |
Cc1ccc(-n2nccn2)c(C(=O)N2CCC[C@@H](COc3nccc4ccccc34)[C@@H]2C)c1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
2.10 | Ki | CHEMBL2413365 | ChEMBL ↗ |
|
169833 ↗ |
Cc1ccc(-n2nccn2)c(C(=O)N2CCC[C@@H](COc3ccccn3)[C@@H]2C)c1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
39.00 | Ki | CHEMBL2413366 | ChEMBL ↗ |
|
169834 ↗ |
COc1ccc(C[C@H]2c3cc(OC)c(OC)cc3CCN2[C@@H](C(=O)NC(C)C)c2ccccc2)cc1OC
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
417.00 | Ki | CHEMBL2413367 | ChEMBL ↗ |
|
169835 ↗ |
O=C(c1cc(F)ccc1-n1nccn1)N1CC[C@H]2CN(c3cnc4ccccc4n3)[C@H]2C1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
40.00 | Ki | CHEMBL2413511 | ChEMBL ↗ |
|
169836 ↗ |
Cc1noc(-c2ccccc2CN2CCCC3(CCN(c4cnc5ccccc5n4)CC3)C2=O)n1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
25.00 | Ki | CHEMBL2413514 | ChEMBL ↗ |
|
169837 ↗ |
Cc1c(S(=O)(=O)Cc2ccc(F)cc2)c2ccccn2c1CC(=O)N(C)Cc1ccc(F)cc1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
5.70 | Ki | CHEMBL2413520 | ChEMBL ↗ |
|
169838 ↗ |
[3H]c1cccc([3H])c1-c1nnc(C[C@@H]2CCCN2C(=O)c2nc(C)sc2-c2ccccc2F)o1
|
CHEMBL4792 ↗
UniProt: O43614 ↗ |
129.00 | Ki | CHEMBL2413521 | ChEMBL ↗ |