CHEMBL4805 IC50
BioactivityChEMBL CHEMBL4805 IC50 bioactivity data
1303 compounds · Target: P2X purinoceptor 7 ( CHEMBL4805 ↗ ) · UniProt: Q99572 ↗ · IC50
P2X purinoceptor 7, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
49065 ↗ |
Cc1cccc2sc(NC(=O)CCN3CCN(c4ccccn4)CC3)nc12
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
1.40×103 | IC50 | CHEMBL5177298 | ChEMBL ↗ |
|
49101 ↗ |
Cc1cccc2sc(NC(=O)CCN3CCN(CCCN(C)C)CC3)nc12
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
18.10×103 | IC50 | CHEMBL5194197 | ChEMBL ↗ |
|
49125 ↗ |
Cc1cccc2sc(NC(=O)CCN3CCN(c4ccncc4)CC3)nc12
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
1.13×103 | IC50 | CHEMBL5206534 | ChEMBL ↗ |
|
49126 ↗ |
Cc1cccc2sc(NC(=O)CCN3CCN(c4ncccn4)CC3)nc12
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
1.33×103 | IC50 | CHEMBL5206663 | ChEMBL ↗ |
|
49127 ↗ |
Cc1cccc2sc(NC(=O)CCN3CCN(CCN(C)C)CC3)nc12
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
2.15×103 | IC50 | CHEMBL5207906 | ChEMBL ↗ |
|
66116 ↗ |
NS(=O)(=O)c1cc(NC(=O)Cc2ccccc2)ccc1Oc1cccc(Cl)c1
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
10.60×103 | IC50 | CHEMBL4521594 | ChEMBL ↗ |
|
69450 ↗ |
O=C(c1ccc(Cl)c(C(F)(F)F)c1)N1CCN(c2cc(=O)[nH]c(=O)n2Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)CC1
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
22.50 | IC50 | CHEMBL3741159 | ChEMBL ↗ |
|
97807 ↗ |
C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
5.00×103 | IC50 | CHEMBL10 | ChEMBL ↗ |
|
117798 ↗ |
CCN(CC)C(=O)N1c2ccccc2C=Cc2ccccc21
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
69.80×103 | IC50 | CHEMBL1483754 | ChEMBL ↗ |
|
117802 ↗ |
O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1ccc2ccccc2c1O
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
797.00 | IC50 | CHEMBL2338686 | ChEMBL ↗ |
|
117826 ↗ |
O=C(NC1CCCCC1)N1c2ccccc2C=Cc2ccccc21
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
40.80×103 | IC50 | CHEMBL3103369 | ChEMBL ↗ |
|
117830 ↗ |
CC(C)N(C(=O)N1c2ccccc2C=Cc2ccccc21)C(C)C
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
95.20×103 | IC50 | CHEMBL3103385 | ChEMBL ↗ |
|
118691 ↗ |
COc1ccc(-c2ccc3c(NC(=O)CC45CC6CC(CC(C6)C4)C5)cccc3n2)cc1
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
23.50 | IC50 | CHEMBL4159276 | ChEMBL ↗ |
|
118787 ↗ |
CN(C)c1ccc(C(=O)N2CCN(c3cc(=O)[nH]c(=O)n3Cc3ccc(OS(=O)(=O)c4cccc5cnccc45)cc3)CC2)cc1
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
1.43 | IC50 | CHEMBL4561852 | ChEMBL ↗ |
|
118805 ↗ |
CN(C)c1ccc(C(=O)N2CCC(n3cncc3-c3ccc(OS(=O)(=O)c4cccc(C(=O)NC5CC5)c4)cc3)CC2)cc1
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
760.00×10-3 | IC50 | CHEMBL4582650 | ChEMBL ↗ |
|
118911 ↗ |
Cc1nc(/N=N/c2ccc(S(=O)(=O)O)cc2S(=O)(=O)O)c(COP(=O)(O)O)c(C=O)c1O
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
1.18×103 | IC50 | CHEMBL69234 | ChEMBL ↗ |
|
131012 ↗ |
CC1=CCC(C(=O)/N=C2\CC=C(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c32)=C/C1=N/C(=O)C1=CC=C/C(=N\C(=O)/N=C2\C=CC=C(C(=O)/N=C3/CC(C(=O)/N=C4\CC=C(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c54)=CC=C3C)C2)C1
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
35.01×103 | IC50 | CHEMBL3040216 | ChEMBL ↗ |
|
172346 ↗ |
Cc1n[nH]c(C)c1CC(=O)NCc1ccc(F)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
19.95 | IC50 | CHEMBL1094106 | ChEMBL ↗ |
|
172347 ↗ |
O=C(NCC1(O)CCC(F)(F)CC1)c1cc(-c2ncc(F)cn2)ccc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
21.00 | IC50 | CHEMBL1094153 | ChEMBL ↗ |
|
172348 ↗ |
Cc1nc(-c2ccccc2)n(C)c1CC(=O)NCc1ccc(F)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
50.12 | IC50 | CHEMBL1094411 | ChEMBL ↗ |
|
172349 ↗ |
Cc1nn(-c2ccccc2)c(C)c1CC(=O)NCc1ccc(Cl)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
79.43 | IC50 | CHEMBL1094482 | ChEMBL ↗ |
|
172350 ↗ |
Cc1nn(-c2ccccc2)c(C)c1CC(=O)NCc1cccc(Cl)c1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
25.12 | IC50 | CHEMBL1094641 | ChEMBL ↗ |
|
172351 ↗ |
Cc1nn(-c2ccc(Cl)cc2)c(C)c1CC(=O)NCc1ccc(F)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
63.10 | IC50 | CHEMBL1094744 | ChEMBL ↗ |
|
172352 ↗ |
Cc1nn(-c2ccccc2)c(C)c1CC(=O)NCc1ccc(F)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
39.81 | IC50 | CHEMBL1095454 | ChEMBL ↗ |
|
172353 ↗ |
Cc1nn(Cc2ccccc2)c(C)c1CC(=O)NCc1ccc(F)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
316.23 | IC50 | CHEMBL1095731 | ChEMBL ↗ |
|
172354 ↗ |
Cc1nn(-c2ccccc2)c(C)c1CC(=O)NCc1ccccc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
1.00×103 | IC50 | CHEMBL1095774 | ChEMBL ↗ |
|
172355 ↗ |
Cc1nn(-c2ccccc2)c(C)c1NC(=O)NCc1ccc(F)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
251.19 | IC50 | CHEMBL1095783 | ChEMBL ↗ |
|
172356 ↗ |
Cc1c(CC(=O)NCc2ccc(F)cc2Cl)cnn1-c1ccccc1
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
158.49 | IC50 | CHEMBL1096029 | ChEMBL ↗ |
|
172357 ↗ |
Cc1nn(Cc2cccnc2)c(C)c1CC(=O)NCc1ccc(F)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
125.89 | IC50 | CHEMBL1096047 | ChEMBL ↗ |
|
172358 ↗ |
Cc1nn(CCO)c(C)c1CC(=O)NCc1ccc(F)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
199.53 | IC50 | CHEMBL1096048 | ChEMBL ↗ |
|
172359 ↗ |
Cc1nn(C)c(C)c1CC(=O)NCc1ccc(F)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
158.49 | IC50 | CHEMBL1096049 | ChEMBL ↗ |
|
172360 ↗ |
Cc1nn(-c2ccccc2)c(C)c1CC(=O)NC(C)(C)c1ccccc1
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
125.89 | IC50 | CHEMBL1096096 | ChEMBL ↗ |
|
172361 ↗ |
Cc1nn(-c2ccccc2)c(C)c1CC(=O)NC1CCCCCC1
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
158.49 | IC50 | CHEMBL1096097 | ChEMBL ↗ |
|
172362 ↗ |
Cc1nn(-c2ccccc2)c(C)c1Cc1nnc(Cc2ccc(Cl)cc2Cl)o1
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
1.26×103 | IC50 | CHEMBL1096099 | ChEMBL ↗ |
|
172363 ↗ |
Cc1nn(-c2ccccc2)cc1CC(=O)NCc1ccc(F)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
158.49 | IC50 | CHEMBL1096100 | ChEMBL ↗ |
|
172364 ↗ |
Cc1nn(-c2ncccn2)c(C)c1CC(=O)NCc1ccc(F)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
50.12 | IC50 | CHEMBL1096314 | ChEMBL ↗ |
|
172365 ↗ |
Cc1nn(CCN(C)C)c(C)c1CC(=O)NCc1ccc(F)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
316.23 | IC50 | CHEMBL1096660 | ChEMBL ↗ |
|
172366 ↗ |
COc1ccc(-n2nc(C)c(CC(=O)NCc3ccc(F)cc3Cl)c2C)cc1
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
100.00 | IC50 | CHEMBL1098722 | ChEMBL ↗ |
|
172367 ↗ |
Cc1nn(-c2ccc(C(N)=O)cc2)c(C)c1CC(=O)NCc1ccc(F)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
10.00 | IC50 | CHEMBL1098723 | ChEMBL ↗ |
|
172368 ↗ |
Cc1nc(/N=N/c2ccc(C(=O)O)cc2)c(COP(=O)(O)O)c(C=O)c1O
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
600.00 | IC50 | CHEMBL119235 | ChEMBL ↗ |
|
172369 ↗ |
Cc1n[nH]c(C)c1CC(=O)NCc1ccc(Cl)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
7.94 | IC50 | CHEMBL1210558 | ChEMBL ↗ |
|
172370 ↗ |
O=C(NCc1ccc(F)cc1Cl)[C@@H]1CCC(=O)N1C1CCCC1
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
501.19 | IC50 | CHEMBL1222519 | ChEMBL ↗ |
|
172371 ↗ |
O=C(NCc1ccc(F)cc1Cl)[C@@H]1CCC(=O)N1c1ccccc1
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
794.33 | IC50 | CHEMBL1222601 | ChEMBL ↗ |
|
172372 ↗ |
CN(C(=O)c1cc(Cl)c(=O)n(Cc2c(Cl)cccc2Cl)c1)c1ccccc1
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
125.89 | IC50 | CHEMBL1222602 | ChEMBL ↗ |
|
172373 ↗ |
CC(C)N1C(=O)CCC1C(=O)NCc1ccc(F)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
316.23 | IC50 | CHEMBL1222603 | ChEMBL ↗ |
|
172374 ↗ |
CC(C)N1C(=O)CC[C@H]1C(=O)NCc1ccc(F)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
100.00 | IC50 | CHEMBL1222604 | ChEMBL ↗ |
|
172375 ↗ |
CN1C(=O)CC[C@H]1C(=O)NCc1ccc(F)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
100.00 | IC50 | CHEMBL1222606 | ChEMBL ↗ |
|
172376 ↗ |
CCN1C(=O)CC[C@H]1C(=O)NCc1ccc(F)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
31.62 | IC50 | CHEMBL1222669 | ChEMBL ↗ |
|
172377 ↗ |
CCCN1C(=O)CC[C@H]1C(=O)NCc1ccc(F)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
158.49 | IC50 | CHEMBL1222670 | ChEMBL ↗ |
|
172378 ↗ |
CC(C)CN1C(=O)CC[C@H]1C(=O)NCc1ccc(F)cc1Cl
|
CHEMBL4805 ↗
UniProt: Q99572 ↗ |
398.11 | IC50 | CHEMBL1222671 | ChEMBL ↗ |