CHEMBL4829 IC50
BioactivityChEMBL CHEMBL4829 IC50 bioactivity data
2525 compounds · Target: Acetyl-CoA carboxylase 2 ( CHEMBL4829 ↗ ) · UniProt: O00763 ↗ · IC50
Acetyl-CoA carboxylase 2, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
66901 ↗ |
CN(C)CCC1CCN(c2cc(C(=O)NC[C@H]3CC[C@H](CNC(=O)OCC(C)(C)C)CC3)c3ccccc3n2)CC1
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
130.00 | IC50 | CHEMBL1818303 | ChEMBL ↗ |
|
68334 ↗ |
CC(C)(C)n1cc2c(n1)C(=O)CC1(CCN(C(=O)c3ccc4[nH]ncc4c3)CC1)O2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
9.90 | IC50 | CHEMBL2419601 | ChEMBL ↗ |
|
68998 ↗ |
CC(C)(C)n1ncc2c1C(=O)CC1(CCN(C(=O)c3ccc4[nH]ncc4c3)CC1)C2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
17.00 | IC50 | CHEMBL3359261 | ChEMBL ↗ |
|
68999 ↗ |
CC(C)n1ncc2c1C(=O)CC1(CCN(C(=O)c3ccc4[nH]ncc4c3)CC1)C2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
30.00 | IC50 | CHEMBL3359262 | ChEMBL ↗ |
|
69000 ↗ |
CC(C)n1ncc2c1C(=O)CC1(CCN(C(=O)c3cnc4cc[nH]c4c3)CC1)C2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
23.00 | IC50 | CHEMBL3359264 | ChEMBL ↗ |
|
69001 ↗ |
Cc1nc2ccc(C(=O)N3CCC4(CC3)CC(=O)c3c(cnn3C(C)C)C4)cc2[nH]1
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
39.00 | IC50 | CHEMBL3359265 | ChEMBL ↗ |
|
177307 ↗ |
CC(=O)N1CCC(C(=O)N2CCC(N3CCN(C(=O)c4cc(-c5ccc(C)cc5)nc(-c5ccc(C)cc5)c4)CC3)CC2)CC1
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
23.00 | IC50 | CHEMBL1076223 | ChEMBL ↗ |
|
177308 ↗ |
Cc1cc(C(=O)N2CCC3(CC2)CC(=O)c2cc(-c4ccn(C)n4)ccc2O3)cc2cn[nH]c12
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
6.10 | IC50 | CHEMBL1088893 | ChEMBL ↗ |
|
177309 ↗ |
Cc1cc(-c2ccc3c(c2)C(=O)CC2(CCN(C(=O)c4cc(C)c5[nH]ncc5c4)CC2)O3)n[nH]1
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
7.60 | IC50 | CHEMBL1088894 | ChEMBL ↗ |
|
177310 ↗ |
COc1cccc2c1C(=O)CC1(CCN(C(=O)c3ccc4[nH]c(-c5ccccn5)nc4c3)CC1)O2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
12.00 | IC50 | CHEMBL1088921 | ChEMBL ↗ |
|
177311 ↗ |
Cc1cc(C(=O)N2CCC3(CC2)CC(=O)c2c(ccnc2OC(C)C)O3)cc2cn[nH]c12
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
4.50 | IC50 | CHEMBL1089181 | ChEMBL ↗ |
|
177312 ↗ |
COc1cccc2c1C(=O)CC1(CCN(C(=O)c3ccc4[nH]nnc4c3)CC1)O2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
505.00 | IC50 | CHEMBL1089206 | ChEMBL ↗ |
|
177313 ↗ |
CNC(=O)c1cc2cc(C(=O)N3CCC4(CC3)CC(=O)c3c(OC)cccc3O4)ccc2[nH]1
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
11.00 | IC50 | CHEMBL1089529 | ChEMBL ↗ |
|
177314 ↗ |
Cc1ncc(-c2ccc3c(c2)C(=O)CC2(CCN(C(=O)c4cc(C)c5[nH]ncc5c4)CC2)O3)o1
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
39.00 | IC50 | CHEMBL1089547 | ChEMBL ↗ |
|
177315 ↗ |
Cc1noc(C)c1-c1ccc2c(c1)C(=O)CC1(CCN(C(=O)c3cc(C)c4[nH]ncc4c3)CC1)O2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
6.40 | IC50 | CHEMBL1089877 | ChEMBL ↗ |
|
177316 ↗ |
Cn1cc(-c2cc3c(cn2)OC2(CCN(C(=O)c4ccc5[nH]c(-c6ccn(C)n6)nc5c4)CC2)CC3=O)cn1
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
210.00×10-3 | IC50 | CHEMBL1089882 | ChEMBL ↗ |
|
177317 ↗ |
Cc1cc(C(=O)N2CCC3(CC2)CC(=O)c2cc(-c4cnn(C)c4)ncc2O3)cc2cn[nH]c12
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
300.00×10-3 | IC50 | CHEMBL1089883 | ChEMBL ↗ |
|
177318 ↗ |
Cc1cc2c(cc1C)C(=O)CC1(CCN(C(=O)c3cccc4cn[nH]c34)CC1)O2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
400.00 | IC50 | CHEMBL1090120 | ChEMBL ↗ |
|
177319 ↗ |
Cc1ccc2c(c1)C(=O)CC1(CCN(C(=O)c3cccc4cn[nH]c34)CC1)O2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
641.00 | IC50 | CHEMBL1090121 | ChEMBL ↗ |
|
177320 ↗ |
COc1nc(C)cc2c1C(=O)CC1(CCN(C(=O)c3cc(C)c4[nH]ncc4c3)CC1)O2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
48.00 | IC50 | CHEMBL1090179 | ChEMBL ↗ |
|
177321 ↗ |
Cc1cc(C(=O)N2CCC3(CC2)CC(=O)c2c(ccnc2OCC(C)C)O3)cc2cn[nH]c12
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
98.00 | IC50 | CHEMBL1090180 | ChEMBL ↗ |
|
177322 ↗ |
Cc1nc(-c2ccc3c(c2)C(=O)CC2(CCN(C(=O)c4cc(C)c5[nH]ncc5c4)CC2)O3)co1
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
30.00 | IC50 | CHEMBL1090193 | ChEMBL ↗ |
|
177323 ↗ |
Cc1n[nH]c2c(C)cc(C(=O)N3CCC4(CC3)CC(=O)c3c(ccnc3OC(C)C)O4)cc12
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
20.00 | IC50 | CHEMBL1090200 | ChEMBL ↗ |
|
177324 ↗ |
Cc1cc(C(=O)N2CCC3(CC2)CC(=O)c2cc(-c4cc[nH]n4)ccc2O3)cc2cn[nH]c12
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
4.50 | IC50 | CHEMBL1090854 | ChEMBL ↗ |
|
177325 ↗ |
COc1cccc2c1C(=O)CC1(CCN(C(=O)c3cc(C)c4[nH]c(C(N)=O)cc4c3)CC1)O2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
16.00 | IC50 | CHEMBL1090862 | ChEMBL ↗ |
|
177326 ↗ |
COc1cccc2c1C(=O)CC1(CCN(C(=O)c3ccc4[nH]c(-c5ccccc5)nc4c3)CC1)O2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
16.00 | IC50 | CHEMBL1090863 | ChEMBL ↗ |
|
177327 ↗ |
COc1cccc2c1C(=O)CC1(CCN(C(=O)c3ccc4[nH]c(C(N)=O)nc4c3)CC1)O2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
16.00 | IC50 | CHEMBL1091186 | ChEMBL ↗ |
|
177328 ↗ |
COc1cccc2c1C(=O)CC1(CCN(C(=O)c3ccc4[nH]cnc4c3)CC1)O2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
111.00 | IC50 | CHEMBL1091187 | ChEMBL ↗ |
|
177329 ↗ |
Cc1cc2c(cc1C)C(=O)CC1(CCN(C(=O)c3cc(C)c4[nH]ncc4c3)CC1)O2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
48.00 | IC50 | CHEMBL1091588 | ChEMBL ↗ |
|
177330 ↗ |
COc1cccc2c1C(=O)CC1(CCN(C(=O)c3cc(C)c4[nH]ncc4c3)CC1)O2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
6.50 | IC50 | CHEMBL1091589 | ChEMBL ↗ |
|
177331 ↗ |
COc1cc2c(cn1)OC1(CCN(C(=O)c3cc(C)c4[nH]ncc4c3)CC1)CC2=O
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
310.00×10-3 | IC50 | CHEMBL1091996 | ChEMBL ↗ |
|
177332 ↗ |
Cc1n[nH]c2ccc(C(=O)N3CCC4(CC3)CC(=O)c3ncccc3O4)cc12
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
640.00 | IC50 | CHEMBL1092007 | ChEMBL ↗ |
|
177333 ↗ |
COc1cccc2c1C(=O)CC1(CCN(C(=O)c3ccc4c(C)n[nH]c4c3)CC1)O2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
164.00 | IC50 | CHEMBL1092296 | ChEMBL ↗ |
|
177334 ↗ |
COc1cccc2c1C(=O)CC1(CCN(C(=O)c3cc(C)c4[nH]nc(C)c4c3)CC1)O2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
11.00 | IC50 | CHEMBL1092308 | ChEMBL ↗ |
|
177335 ↗ |
CCc1cc(C(=O)N2CCC3(CC2)CC(=O)c2c(OC)cccc2O3)cc2cn[nH]c12
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
151.00 | IC50 | CHEMBL1092380 | ChEMBL ↗ |
|
177336 ↗ |
COc1cccc2c1C(=O)CC1(CCN(C(=O)c3ccc4[nH]c(-c5cccnc5)nc4c3)CC1)O2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
19.00 | IC50 | CHEMBL1092605 | ChEMBL ↗ |
|
177337 ↗ |
COc1cccc2c1C(=O)CC1(CCN(C(=O)c3ccc4[nH]c(-c5ccncc5)nc4c3)CC1)O2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
51.00 | IC50 | CHEMBL1092606 | ChEMBL ↗ |
|
177338 ↗ |
Cc1n[nH]c2c(C)cc(C(=O)N3CCC4(CC3)CC(=O)c3ncccc3O4)cc12
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
363.00 | IC50 | CHEMBL1093166 | ChEMBL ↗ |
|
177339 ↗ |
O=C1CC2(CCN(C(=O)c3cccc4cn[nH]c34)CC2)Oc2ccc(Cl)cc21
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
2.13×103 | IC50 | CHEMBL1093803 | ChEMBL ↗ |
|
177340 ↗ |
COc1cccc2c1C(=O)CC1(CCN(C(=O)c3cc(C)c4[nH]cnc4c3)CC1)O2
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
126.00 | IC50 | CHEMBL1093809 | ChEMBL ↗ |
|
177341 ↗ |
CC(C)(C)OC(=O)NC[C@H]1CC[C@H](CNC(=O)c2cc(-c3ccc(CN)cc3)nc3ccccc23)CC1
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
330.00 | IC50 | CHEMBL1615283 | ChEMBL ↗ |
|
177342 ↗ |
COC(=O)NC(C)CCc1ccc(Oc2ccc(OC(C)C)nc2)cc1
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
230.00 | IC50 | CHEMBL1629723 | ChEMBL ↗ |
|
177343 ↗ |
CC(=O)NCCCC1OCC(Cc2cccc(OCCC3CCCC3)c2)CO1
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
270.00 | IC50 | CHEMBL1630515 | ChEMBL ↗ |
|
177344 ↗ |
CC(=O)N[C@@H](C)C#Cc1cnc(Oc2ccc(OC(C)C)cc2)s1
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
60.00 | IC50 | CHEMBL1630516 | ChEMBL ↗ |
|
177345 ↗ |
CC(=O)NCCCC1OCC(c2cccc3cc(OC4CCCC4)ccc23)CO1
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
630.00 | IC50 | CHEMBL1630517 | ChEMBL ↗ |
|
177346 ↗ |
CC(=O)NCCCC1OCC(Cc2cccc(OCCC3CC3)c2)CO1
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
2.65×103 | IC50 | CHEMBL1630518 | ChEMBL ↗ |
|
177347 ↗ |
CC(=O)NCCCC1OCC(Cc2cccc(OCCc3ccccc3)c2)CO1
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
2.10×103 | IC50 | CHEMBL1630519 | ChEMBL ↗ |
|
177348 ↗ |
CC(=O)NCCCC1OCC(Cc2cccc(OCC3CCC3)c2)CO1
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
700.00 | IC50 | CHEMBL1630520 | ChEMBL ↗ |
|
177349 ↗ |
CC(CCc1ccc(Oc2ccc(OC(C)C)nc2)cc1)NC(=O)C1CC1
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
140.00 | IC50 | CHEMBL1630700 | ChEMBL ↗ |
|
177350 ↗ |
CC(C)Oc1ccc(Oc2ccc(CC[C@H](C)NC(=O)C3CC3)cc2)cn1
|
CHEMBL4829 ↗
UniProt: O00763 ↗ |
80.00 | IC50 | CHEMBL1630701 | ChEMBL ↗ |