CHEMBL5145 IC50
BioactivityChEMBL CHEMBL5145 IC50 bioactivity data
1638 compounds · Target: Serine/threonine-protein kinase B-raf ( CHEMBL5145 ↗ ) · UniProt: P15056 ↗ · IC50
Serine/threonine-protein kinase B-raf, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
5528 ↗ |
COc1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)cc(OC)c1OC
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
40.00×103 | IC50 | CHEMBL201511 | ChEMBL ↗ |
|
5671 ↗ |
O=C(NCCc1ccc(O)c(Br)c1)/C(Cc1cc(Br)c(O)c(Oc2ccc(CCNC(=O)/C(Cc3cc(Br)c(O)c(-c4cc(C/C(=N\O)C(=O)NCCc5ccc(O)c(Br)c5)cc(Br)c4O)c3)=N/O)cc2Br)c1)=N/O
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
1.70×103 | IC50 | CHEMBL2333163 | ChEMBL ↗ |
|
5682 ↗ |
O=C(NCCO)C1=Cc2c(ncnc2Nc2ccc(Oc3cccc4sccc34)c(Cl)c2)NCC1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
230.00 | IC50 | CHEMBL2348417 | ChEMBL ↗ |
|
5846 ↗ |
O=C1N/C=C/c2ccc(c(Br)c2)Oc2cc(cc(Br)c2O)CCNC(=O)/C(=N/O)Cc2ccc(c(Br)c2)Oc2cc(cc(Br)c2O)C/C1=N\O
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
4.40×103 | IC50 | CHEMBL360190 | ChEMBL ↗ |
|
5928 ↗ |
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
2.04×103 | IC50 | CHEMBL3884319 | ChEMBL ↗ |
|
5930 ↗ |
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
7.67 | IC50 | CHEMBL388978 | ChEMBL ↗ |
|
6315 ↗ |
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
19.00 | IC50 | CHEMBL4568087 | ChEMBL ↗ |
|
6316 ↗ |
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
550.00 | IC50 | CHEMBL4569508 | ChEMBL ↗ |
|
6386 ↗ |
Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
98.50 | IC50 | CHEMBL4798527 | ChEMBL ↗ |
|
6390 ↗ |
CC(C)Oc1cc(F)ccc1Nc1ncnc2ccc(-c3ccc(C(=O)N4CCNCC4)cc3)nc12
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
2.22×103 | IC50 | CHEMBL4869634 | ChEMBL ↗ |
|
6391 ↗ |
COc1cc(C2=C(c3cn(COC(C)(C)C)c4ccccc34)CNC2=O)cc(OC)c1OC
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
38.00×103 | IC50 | CHEMBL488646 | ChEMBL ↗ |
|
6393 ↗ |
N=C(N)SCCCn1c(=O)c2c(c1=O)n1c3ccccc3cc1c1cccc3ccn2c31
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
1.20×103 | IC50 | CHEMBL489083 | ChEMBL ↗ |
|
6407 ↗ |
O=C(NCCc1ccc(O)c(Br)c1)/C(Cc1cc(Br)c(O)c(-c2cc(C/C(=N/O)C(=O)NCCc3ccc(O)c(Br)c3)cc(Br)c2O)c1)=N\O
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
2.70×103 | IC50 | CHEMBL505637 | ChEMBL ↗ |
|
6570 ↗ |
O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
1.76×103 | IC50 | CHEMBL6246 | ChEMBL ↗ |
|
13340 ↗ |
O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
7.59×103 | IC50 | CHEMBL50 | ChEMBL ↗ |
|
16522 ↗ |
N#Cc1ccc(-c2cnc3ccc(NCc4ccccc4)nn23)cc1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
2.50×103 | IC50 | CHEMBL3582427 | ChEMBL ↗ |
|
16523 ↗ |
O=C(O)CN1CCN(c2cc(-c3cnc4ccc(N5CCC[C@@H]5c5cccc(F)c5)nn34)ccn2)CC1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
6.20×103 | IC50 | CHEMBL3582441 | ChEMBL ↗ |
|
16524 ↗ |
OC1CCN(c2cc(-c3cnc4ccc(N5CCC[C@@H]5c5cccc(F)c5)nn34)ccn2)CC1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
5.90×103 | IC50 | CHEMBL3582442 | ChEMBL ↗ |
|
17551 ↗ |
Nc1n[nH]c2cccc(-c3ccc(NC(=S)Nc4cc(Br)ccc4OC(F)(F)F)cc3)c12
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
20.00 | IC50 | CHEMBL4160854 | ChEMBL ↗ |
|
17553 ↗ |
C=CC(=O)Nc1ccc(-c2ccc(NC(=O)Nc3cccc(Cl)c3)cc2)cn1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
32.00 | IC50 | CHEMBL4171543 | ChEMBL ↗ |
|
17679 ↗ |
O=c1c(O)c(-c2cc(O)c(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
1.56×103 | IC50 | CHEMBL164 | ChEMBL ↗ |
|
18646 ↗ |
CNC(=O)c1cc(Oc2ccc(C3=NNC(c4cccc(Br)c4)C3)cc2)ccn1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
3.40×103 | IC50 | CHEMBL4217207 | ChEMBL ↗ |
|
18654 ↗ |
CNC(=O)c1ccc(Sc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)nc1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
25.00 | IC50 | CHEMBL4224704 | ChEMBL ↗ |
|
18655 ↗ |
CNC(=O)c1ccc(Sc2ccc(NC(=S)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)nc1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
27.50 | IC50 | CHEMBL4225772 | ChEMBL ↗ |
|
18656 ↗ |
CNC(=O)c1ccc(Sc2cccc(NC(=S)Nc3ccc(Cl)c(C(F)(F)F)c3)c2)nc1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
16.50 | IC50 | CHEMBL4225828 | ChEMBL ↗ |
|
18950 ↗ |
Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
1.10×103 | IC50 | CHEMBL4552628 | ChEMBL ↗ |
|
19103 ↗ |
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
957.00 | IC50 | CHEMBL4793380 | ChEMBL ↗ |
|
19105 ↗ |
Nc1n[nH]c2cccc(C#Cc3cccc(NC(=O)c4ccc(N5CCOCC5)c(C(F)(F)F)c4)c3)c12
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
122.00 | IC50 | CHEMBL4793906 | ChEMBL ↗ |
|
19206 ↗ |
c1ccc(COc2cccc(-c3nc4sccn4c3-c3ccncn3)c2)cc1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
1.29×103 | IC50 | CHEMBL4866102 | ChEMBL ↗ |
|
19320 ↗ |
COc1cc(C2=C(c3cn(C)c4ccccc34)C(=O)NC2)cc(OC)c1OC
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
50.00×103 | IC50 | CHEMBL509435 | ChEMBL ↗ |
|
21498 ↗ |
COc1cc2ncnc(Nc3ccc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)cc3)c2cc1OCCCN1CCOCC1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
455.00 | IC50 | CHEMBL3133751 | ChEMBL ↗ |
|
21499 ↗ |
COc1cc2ncnc(Nc3cccc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)c3)c2cc1OCCCN1CCOCC1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
135.00 | IC50 | CHEMBL3133752 | ChEMBL ↗ |
|
21500 ↗ |
COc1cc2ncnc(Nc3cccc(NC(=O)Nc4cccc(C)c4)c3)c2cc1OCCCN1CCOCC1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
86.50 | IC50 | CHEMBL3133754 | ChEMBL ↗ |
|
21501 ↗ |
O=C(Nc1cccc(Nc2ncnc3cc(OCCCN4CCOCC4)ccc23)c1)Nc1ccc(F)c(Cl)c1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
57.00 | IC50 | CHEMBL3133755 | ChEMBL ↗ |
|
21502 ↗ |
O=C(Nc1cccc(Nc2ncnc3cc(OCCCN4CCN(CCO)CC4)ccc23)c1)Nc1ccc(Cl)c(C(F)(F)F)c1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
79.50 | IC50 | CHEMBL3133756 | ChEMBL ↗ |
|
21503 ↗ |
CCN(CCO)CCCOc1ccc2c(Nc3cccc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)c3)ncnc2c1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
82.50 | IC50 | CHEMBL3133757 | ChEMBL ↗ |
|
21504 ↗ |
CCN(CCO)CCCOc1ccc2c(Nc3cccc(NC(=O)Nc4ccc(F)c(Cl)c4)c3)ncnc2c1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
17.50 | IC50 | CHEMBL3133758 | ChEMBL ↗ |
|
21553 ↗ |
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1NC(=O)c1cccnc1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
551.00 | IC50 | CHEMBL3234736 | ChEMBL ↗ |
|
21554 ↗ |
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1NC(=O)c1ccccn1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
573.00 | IC50 | CHEMBL3234737 | ChEMBL ↗ |
|
21555 ↗ |
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1NC(=O)c1cnccn1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
280.00 | IC50 | CHEMBL3234740 | ChEMBL ↗ |
|
21556 ↗ |
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1NC(=O)c1cncnc1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
670.00 | IC50 | CHEMBL3234741 | ChEMBL ↗ |
|
21557 ↗ |
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1NC(=O)c1cnc(N)nc1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
410.00 | IC50 | CHEMBL3234742 | ChEMBL ↗ |
|
21559 ↗ |
CNc1ncc(C(=O)Nc2cc(C(=O)Nc3ccc(CN4CCN(C)CC4)c(C(F)(F)F)c3)ccc2C)cn1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
290.00 | IC50 | CHEMBL3234744 | ChEMBL ↗ |
|
21560 ↗ |
CCNc1ncc(C(=O)Nc2cc(C(=O)Nc3ccc(CN4CCN(C)CC4)c(C(F)(F)F)c3)ccc2C)cn1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
510.00 | IC50 | CHEMBL3234745 | ChEMBL ↗ |
|
21561 ↗ |
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1NC(=O)c1cnc(NC(C)C)nc1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
340.00 | IC50 | CHEMBL3234746 | ChEMBL ↗ |
|
21562 ↗ |
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1NC(=O)c1cnc(NC2CC2)nc1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
390.00 | IC50 | CHEMBL3234747 | ChEMBL ↗ |
|
21563 ↗ |
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1NC(=O)c1cnc(NC2CCCC2)nc1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
230.00 | IC50 | CHEMBL3234748 | ChEMBL ↗ |
|
21564 ↗ |
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1NC(=O)c1cnc(NC2CCCCC2)nc1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
37.00 | IC50 | CHEMBL3234749 | ChEMBL ↗ |
|
21565 ↗ |
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1NC(=O)c1cnc(Nc2ccccc2)nc1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
210.00 | IC50 | CHEMBL3234750 | ChEMBL ↗ |
|
21566 ↗ |
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1NC(=O)c1cnc(N(C)C)nc1
|
CHEMBL5145 ↗
UniProt: P15056 ↗ |
300.00 | IC50 | CHEMBL3234751 | ChEMBL ↗ |