CHEMBL5251 IC50
BioactivityChEMBL CHEMBL5251 IC50 bioactivity data
1743 compounds · Target: Tyrosine-protein kinase BTK ( CHEMBL5251 ↗ ) · UniProt: Q06187 ↗ · IC50
Tyrosine-protein kinase BTK, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
5378 ↗ |
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
4.00 | IC50 | CHEMBL1421 | ChEMBL ↗ |
|
5802 ↗ |
C=CC(=O)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)cn2)c1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
15.25 | IC50 | CHEMBL3290142 | ChEMBL ↗ |
|
5803 ↗ |
C=CC(=O)NCC(=O)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)cn2)c1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
13.00 | IC50 | CHEMBL3290148 | ChEMBL ↗ |
|
5862 ↗ |
Cc1cc(Nc2nc(Nc3ccccc3S(=O)(=O)C(C)C)c3c(C)[nH]nc3n2)c(OC(C)C)cc1C1CCN(C)CC1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
9.40×103 | IC50 | CHEMBL3651854 | ChEMBL ↗ |
|
5928 ↗ |
CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
1.88×103 | IC50 | CHEMBL3884319 | ChEMBL ↗ |
|
6217 ↗ |
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(OCc4ccccn4)c(Cl)c3)c3c(N)ncnc32)C1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
24.50 | IC50 | CHEMBL4068839 | ChEMBL ↗ |
|
6236 ↗ |
C=CS(=O)(=O)N1CCC[C@@H]1Cn1cc(-c2ccc3c(c2)OCO3)c2c(N)ncnc21
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
88.60 | IC50 | CHEMBL4095253 | ChEMBL ↗ |
|
6259 ↗ |
C=CC(=O)N[C@@H]1Cn2c(c(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1=C
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
400.00×10-3 | IC50 | CHEMBL4211949 | ChEMBL ↗ |
|
6303 ↗ |
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC)cc1N(C)CCN(C)C
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
2.00 | IC50 | CHEMBL4473365 | ChEMBL ↗ |
|
6316 ↗ |
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
290.00 | IC50 | CHEMBL4569508 | ChEMBL ↗ |
|
6347 ↗ |
COc1cc2nccc(Oc3ccc(C(=O)Nc4ccccn4)cc3)c2cc1NC(=O)C#CCCN1CCOCC1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
1.55 | IC50 | CHEMBL4755977 | ChEMBL ↗ |
|
6445 ↗ |
CC#CC(=O)N1CCC[C@H]1n1nc(-c2ccc(C(=O)Nc3ccccn3)cc2)c2c(N)ncnc21
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
5.10 | IC50 | CHEMBL5187554 | ChEMBL ↗ |
|
6453 ↗ |
C=CC(=O)N1CCC([C@@H]2CCNC3C(C(N)=O)C(c4ccc(Oc5ccccc5)cc4)=NN32)CC1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
500.00×10-3 | IC50 | CHEMBL5193128 | ChEMBL ↗ |
|
15948 ↗ |
O=C1/C(=C/c2ccc(O)c(O)c2)Oc2cc(O)ccc21
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
6.02×103 | IC50 | CHEMBL490355 | ChEMBL ↗ |
|
16199 ↗ |
Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
7.60×103 | IC50 | CHEMBL1614712 | ChEMBL ↗ |
|
16283 ↗ |
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
4.95×103 | IC50 | CHEMBL2006765 | ChEMBL ↗ |
|
16996 ↗ |
CNc1ncnc(-c2cccnc2Oc2ccc(F)c(C(=O)Nc3cc(C(F)(F)F)ccc3N(C)CCCN(C)C)c2)n1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
25.00×103 | IC50 | CHEMBL373882 | ChEMBL ↗ |
|
17017 ↗ |
Nc1ncnc2c1c(-c1cccc(O)c1)cn2[C@H]1C[C@@H](CN2CCC2)C1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
580.00 | IC50 | CHEMBL3787112 | ChEMBL ↗ |
|
17541 ↗ |
CC1(C)OCC(=O)Nc2cc(Nc3nc(NCC(F)(F)F)c4occc4n3)ccc21
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
5.02×103 | IC50 | CHEMBL4069365 | ChEMBL ↗ |
|
17726 ↗ |
CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
93.00 | IC50 | CHEMBL2010872 | ChEMBL ↗ |
|
17884 ↗ |
Oc1cccc(Nc2ccnc3cc(-c4cccc(CN5CCOCC5)c4)sc23)c1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
17.70 | IC50 | CHEMBL2336005 | ChEMBL ↗ |
|
17941 ↗ |
C=CC(=O)Nc1cccc(-n2c(=O)cnc3cnc(Nc4ccc(N5CCN(C)CC5)cc4)nc32)c1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
1.20 | IC50 | CHEMBL2437462 | ChEMBL ↗ |
|
17951 ↗ |
C=CC(=O)Nc1cccc(-n2c(=O)cnc3cnc(Nc4ccc(OC)cc4)nc32)c1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
1.80 | IC50 | CHEMBL2437479 | ChEMBL ↗ |
|
18132 ↗ |
C=CC(=O)Nc1cccc(CNc2nc(Nc3ccc(N4CCN(C)CC4)cc3OC)ncc2Cl)c1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
794.00 | IC50 | CHEMBL3601223 | ChEMBL ↗ |
|
18250 ↗ |
CN(C)CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
421.00 | IC50 | CHEMBL3745919 | ChEMBL ↗ |
|
18560 ↗ |
CC(C)(C)c1cc(NC(=O)Nc2ccc(-n3nc(-c4ccc(OCCN5CCOCC5)cc4)c4c(N)ncnc43)cc2)no1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
95.00 | IC50 | CHEMBL4101411 | ChEMBL ↗ |
|
18859 ↗ |
CN1CCC(Nc2ccc(C(=O)Nc3cc(-c4cc(C#N)cs4)n[nH]3)cc2)CC1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
1.61×103 | IC50 | CHEMBL4473820 | ChEMBL ↗ |
|
18950 ↗ |
Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
13.00×103 | IC50 | CHEMBL4552628 | ChEMBL ↗ |
|
21190 ↗ |
COc1ccccc1CNc1ncc(C(=O)NC2CCN(C)CC2)c(NC2CCCC2)n1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
30.00×103 | IC50 | CHEMBL2312645 | ChEMBL ↗ |
|
21191 ↗ |
CN1CCC(NC(=O)c2cnc(NCc3cc(Cl)ccc3Cl)nc2NC2CCCC2)CC1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
25.67×103 | IC50 | CHEMBL2312646 | ChEMBL ↗ |
|
21192 ↗ |
CN1CCC(NC(=O)c2cnc(Nc3cc(Cl)cc(Cl)c3)nc2NC2CCC(N(C)C)CC2)CC1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
30.00×103 | IC50 | CHEMBL2312649 | ChEMBL ↗ |
|
21193 ↗ |
CN1CCC(NC(=O)c2cnc(Nc3cc(Cl)cc(Cl)c3)nc2N[C@@H]2COC[C@H]2O)CC1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
30.00×103 | IC50 | CHEMBL2312652 | ChEMBL ↗ |
|
21194 ↗ |
Cc1cc(-c2cnc(Nc3cc(Cl)cc(Cl)c3)nc2NC2CCC(N(C)C)CC2)on1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
950.00 | IC50 | CHEMBL2312654 | ChEMBL ↗ |
|
21331 ↗ |
C=CC(=O)Nc1cccc(-n2c(=O)c(C)nc3cnc(Nc4ccc(OC)cc4)nc32)c1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
1.20 | IC50 | CHEMBL2437471 | ChEMBL ↗ |
|
21336 ↗ |
CCc1ccc2nc(Nc3cc(Cc4ccccc4)nc(N[C@H]4CC[C@H](O)CC4)n3)sc2c1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
316.23 | IC50 | CHEMBL2441273 | ChEMBL ↗ |
|
21780 ↗ |
CCn1nc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(C)CC4)c(C(F)(F)F)c3)ccc2C)c2c(N)ncnc21
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
67.00 | IC50 | CHEMBL3426225 | ChEMBL ↗ |
|
21928 ↗ |
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/[C@H]1CCCN1C
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
31.70 | IC50 | CHEMBL3647420 | ChEMBL ↗ |
|
22716 ↗ |
C=CC(=O)N1CCc2ccc(-n3c(=O)ccc4cnc5ccc(-c6cnn(C)c6)cc5c43)cc21
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
6.79 | IC50 | CHEMBL4077064 | ChEMBL ↗ |
|
22762 ↗ |
C=CC(=O)Nc1cc(Nc2cc(-c3cccc(NC(=O)c4ccc(N(C)C)cc4)c3C)cn(C)c2=O)ccc1C(=O)N1CCOCC1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
5.80 | IC50 | CHEMBL4085868 | ChEMBL ↗ |
|
22822 ↗ |
C=CC(=O)Nc1cc(Nc2cc(-c3cccc(NC(=O)c4cc5c(s4)CCCC5)c3C)cn(C)c2=O)ccc1C(=O)N1CCOCC1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
16.50 | IC50 | CHEMBL4096207 | ChEMBL ↗ |
|
22877 ↗ |
C=CC(=O)Nc1cccc(-n2c(=O)n(C)c(=O)c3cnc(Nc4ccc(N5CCSCC5)cc4OC)nc32)c1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
806.00 | IC50 | CHEMBL4125772 | ChEMBL ↗ |
|
22878 ↗ |
C=CC(=O)Nc1cccc(-n2c(=O)n(C(C)C)c(=O)c3cnc(Nc4ccc(N5CCN(C)CC5)c(OC)c4)nc32)c1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
1.20 | IC50 | CHEMBL4125940 | ChEMBL ↗ |
|
22879 ↗ |
C=CC(=O)Nc1cccc(-n2c(=O)n(CC)c(=O)c3cnc(Nc4ccc(N5CCC(N(C)C)CC5)cc4OC)nc32)c1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
396.00 | IC50 | CHEMBL4126358 | ChEMBL ↗ |
|
22880 ↗ |
C=CC(=O)Nc1cccc(-n2c(=O)n(C(C)C)c(=O)c3cnc(Nc4ccc(N5CCN(C)CC5)c(C)c4)nc32)c1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
800.00×10-3 | IC50 | CHEMBL4126630 | ChEMBL ↗ |
|
22881 ↗ |
C=CC(=O)Nc1cccc(-n2c(=O)n(C)c(=O)c3cnc(Nc4ccc(N5CCOCC5)cc4OC)nc32)c1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
852.00 | IC50 | CHEMBL4126654 | ChEMBL ↗ |
|
22882 ↗ |
C=CC(=O)Nc1cccc(-n2c(=O)n(C)c(=O)c3cnc(Nc4ccc(N5CCN(C(C)=O)CC5)cc4OC)nc32)c1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
718.00 | IC50 | CHEMBL4126797 | ChEMBL ↗ |
|
22883 ↗ |
C=CC(=O)Nc1cccc(-n2c(=O)n(C(C)C)c(=O)c3cnc(Nc4ccc(OCCN(C)C)cc4OC)nc32)c1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
349.00 | IC50 | CHEMBL4126986 | ChEMBL ↗ |
|
22884 ↗ |
C=CC(=O)Nc1cccc(-n2c(=O)n(C(C)C)c(=O)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
518.00 | IC50 | CHEMBL4127317 | ChEMBL ↗ |
|
22885 ↗ |
C=CC(=O)Nc1cccc(-n2c(=O)n(Cc3ccccc3)c(=O)c3cnc(Nc4ccc(N5CCC(N(C)C)CC5)cc4OC)nc32)c1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
248.00 | IC50 | CHEMBL4128415 | ChEMBL ↗ |
|
22886 ↗ |
C=CC(=O)Nc1cccc(-n2c(=O)n(CCc3ccccc3)c(=O)c3cnc(Nc4ccc(N5CCC(N(C)C)CC5)cc4OC)nc32)c1
|
CHEMBL5251 ↗
UniProt: Q06187 ↗ |
23.00 | IC50 | CHEMBL4128567 | ChEMBL ↗ |