CHEMBL5658 IC50
BioactivityChEMBL CHEMBL5658 IC50 bioactivity data
1028 compounds · Target: Prostaglandin E synthase ( CHEMBL5658 ↗ ) · UniProt: O14684 ↗ · IC50
Prostaglandin E synthase, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
8041 ↗ |
Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
482.50 | IC50 | CHEMBL118 | ChEMBL ↗ |
|
14286 ↗ |
COc1cc(/C=C/C(=O)CC(=O)/C=C/c2ccc(O)c(OC)c2)ccc1O
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
210.00 | IC50 | CHEMBL140 | ChEMBL ↗ |
|
20752 ↗ |
CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1OC1CCCCC1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
20.00×103 | IC50 | CHEMBL7162 | ChEMBL ↗ |
|
20840 ↗ |
COc1cc(/C=C/C(=O)/C=C(O)/C=C/c2ccc(O)c(OC)c2)ccc1O
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
900.00 | IC50 | CHEMBL116438 | ChEMBL ↗ |
|
44725 ↗ |
O=C(O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
1.80×103 | IC50 | CHEMBL297453 | ChEMBL ↗ |
|
49347 ↗ |
CC(C)=CCC1=C(O)[C@@]2(C(=O)C(C)C)C(=O)[C@](CC=C(C)C)(C[C@H](CC=C(C)C)[C@@]2(C)CCC=C(C)C)C1=O
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
1.00×103 | IC50 | CHEMBL1237210 | ChEMBL ↗ |
|
58493 ↗ |
O=C(Nc1ccc(-c2ccccc2)cc1)C1=C(O)c2ccccc2S(=O)(=O)N1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
4.93×103 | IC50 | CHEMBL1076742 | ChEMBL ↗ |
|
58526 ↗ |
O=C(Nc1ccc(-c2cccc(Cl)c2Cl)cc1)C1=C(O)c2ccccc2S(=O)(=O)N1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
38.00 | IC50 | CHEMBL1086757 | ChEMBL ↗ |
|
58529 ↗ |
O=C(Nc1cccc(C(=O)c2ccc(Cl)cc2)c1)C1=C(O)c2ccccc2S(=O)(=O)N1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
3.04×103 | IC50 | CHEMBL1088301 | ChEMBL ↗ |
|
58539 ↗ |
CCCCC(Sc1nc(OCCC2CCCCC2)cc(OCCC2CCCCC2)n1)C(=O)O
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
2.40×103 | IC50 | CHEMBL1171834 | ChEMBL ↗ |
|
58555 ↗ |
CC(=O)c1c(O)cc(O)c(C/C=C(\C)CCC=C(C)C)c1O
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
3.50×103 | IC50 | CHEMBL1242095 | ChEMBL ↗ |
|
58979 ↗ |
O=C(N[C@H]1CCC[C@@H]1COc1ccccc1)C1CCN(c2nc3cc(Cl)ccc3o2)CC1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
34.00 | IC50 | CHEMBL2315856 | ChEMBL ↗ |
|
58980 ↗ |
O=C(NC1CCCC1)C1CCN(c2nc3cc(Cl)ccc3o2)CC1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
851.50 | IC50 | CHEMBL2315877 | ChEMBL ↗ |
|
59150 ↗ |
CC(C)c1ccc2c(c1)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n2Cc1ccc(Cl)cc1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
2.26×103 | IC50 | CHEMBL29097 | ChEMBL ↗ |
|
59156 ↗ |
CC1(C)Cc2c(-c3ccccc3)c(-c3ccc(Cl)cc3)c(CC(=O)O)n2C1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
6.35×103 | IC50 | CHEMBL300982 | ChEMBL ↗ |
|
59302 ↗ |
COc1cc(/C=C/c2cc(/C=C/c3cc(CC=C(C)C)c(O)c(OC)c3)[nH]n2)cc(CC=C(C)C)c1O
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
13.00 | IC50 | CHEMBL3290441 | ChEMBL ↗ |
|
64149 ↗ |
CCCC/C(=C\c1cc(OCc2ccc3nc(C(F)(F)F)cc(OC)c3c2)ccc1OCc1ccc(C(F)(F)F)cc1)C(=O)O
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
3.00×103 | IC50 | CHEMBL3397721 | ChEMBL ↗ |
|
64739 ↗ |
Cc1cccc(Nc2cc(Cl)nc(SC(C(=O)O)c3cccc4ccccc34)n2)c1C
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
5.10×103 | IC50 | CHEMBL455936 | ChEMBL ↗ |
|
64743 ↗ |
CCCCCCC(Sc1nc(Cl)cc(Nc2ccc(-c3ccc(C#N)cc3)cc2)n1)C(=O)O
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
1.70×103 | IC50 | CHEMBL456792 | ChEMBL ↗ |
|
64871 ↗ |
CCCCCCC(Sc1nc(Cl)cc(Nc2cccc(C)c2C)n1)C(=O)O
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
3.65×103 | IC50 | CHEMBL518038 | ChEMBL ↗ |
|
72220 ↗ |
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
40.60×103 | IC50 | CHEMBL6 | ChEMBL ↗ |
|
74958 ↗ |
COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
18.10×103 | IC50 | CHEMBL603 | ChEMBL ↗ |
|
74969 ↗ |
CC(c1cc2ccccc2s1)N(O)C(N)=O
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
600.00 | IC50 | CHEMBL93 | ChEMBL ↗ |
|
114668 ↗ |
CCCCC(Sc1nc(OCCc2ccc(C(F)(F)F)cc2)cc(OCCc2ccc(C(F)(F)F)cc2)n1)C(=O)O
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
1.90×103 | IC50 | CHEMBL1170264 | ChEMBL ↗ |
|
114890 ↗ |
C/C=C/c1ccc2oc(-c3ccc(O)cc3O)cc2c1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
7.40×103 | IC50 | CHEMBL2147420 | ChEMBL ↗ |
|
114891 ↗ |
C/C=C/c1ccc2oc(-c3ccc(O)cc3)cc2c1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
5.30×103 | IC50 | CHEMBL2147422 | ChEMBL ↗ |
|
114892 ↗ |
C/C=C/c1ccc2oc(-c3ccc(O)cc3OC)cc2c1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
13.50×103 | IC50 | CHEMBL2147423 | ChEMBL ↗ |
|
115298 ↗ |
O=[N+]([O-])c1cc([N+](=O)[O-])c(-c2ccccc2COc2cccc(C(F)(F)F)c2)cc1F
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
540.00 | IC50 | CHEMBL4293214 | ChEMBL ↗ |
|
115341 ↗ |
CCCCC(Sc1nc(OCCc2ccccc2)cc(OCCc2ccccc2)n1)C(=O)O
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
1.20×103 | IC50 | CHEMBL461883 | ChEMBL ↗ |
|
115345 ↗ |
C/C=C/c1ccc2oc(-c3ccc(O)cc3)c(C)c2c1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
11.00×103 | IC50 | CHEMBL463574 | ChEMBL ↗ |
|
130430 ↗ |
COc1ccc(Sc2cccc(CN(C)c3cc(C(=O)O)nc4cc(Cl)cc(Cl)c34)c2)cc1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
3.00×103 | IC50 | CHEMBL1774309 | ChEMBL ↗ |
|
137572 ↗ |
COC(=O)c1c(C)cc(OC(=O)c2c(C)cc(O)c(C=O)c2O)c(C)c1O
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
1.15×103 | IC50 | CHEMBL173395 | ChEMBL ↗ |
|
184477 ↗ |
Oc1ccc(Nc2nc(-c3ccc4ccccc4c3)cs2)cc1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
58.00 | IC50 | CHEMBL1076559 | ChEMBL ↗ |
|
184478 ↗ |
O=C(CNS(=O)(=O)c1ccccc1CO)Nc1ccc(-c2ccc(Cl)c(Cl)c2)cc1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
29.60×103 | IC50 | CHEMBL1076568 | ChEMBL ↗ |
|
184479 ↗ |
O=C(Nc1ccc(-c2ccc(Cl)c(Cl)c2)cn1)C1=C(O)c2ccccc2S(=O)(=O)N1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
65.60×103 | IC50 | CHEMBL1080509 | ChEMBL ↗ |
|
184480 ↗ |
O=C(Nc1ccc(-c2ccc(Cl)cc2Cl)cn1)C1=C(O)c2ccccc2S(=O)(=O)N1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
11.70×103 | IC50 | CHEMBL1080851 | ChEMBL ↗ |
|
184481 ↗ |
COc1ccc2c(c1)C(O)=C(C(=O)Nc1ccc(-c3ccc(Cl)c(Cl)c3)cc1)NS2(=O)=O
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
990.00 | IC50 | CHEMBL1080852 | ChEMBL ↗ |
|
184482 ↗ |
COc1ccc2c(c1)S(=O)(=O)NC(C(=O)Nc1ccc(-c3ccc(Cl)c(Cl)c3)cc1)=C2O
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
3.05×103 | IC50 | CHEMBL1081034 | ChEMBL ↗ |
|
184483 ↗ |
COc1ccc(-c2ccc(NC(=O)C3=C(O)c4ccccc4S(=O)(=O)N3)cc2)cc1OC
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
32.20×103 | IC50 | CHEMBL1082014 | ChEMBL ↗ |
|
184484 ↗ |
O=C(Nc1ccc(-c2ccc(Cl)c(Cl)c2)cc1)C1=C(O)c2ccc(O)cc2S(=O)(=O)N1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
180.00 | IC50 | CHEMBL1082145 | ChEMBL ↗ |
|
184485 ↗ |
O=C(Nc1ccc(-c2ccc(Cl)nc2)cc1)C1=C(O)c2ccccc2S(=O)(=O)N1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
12.70×103 | IC50 | CHEMBL1082180 | ChEMBL ↗ |
|
184486 ↗ |
O=C(Nc1ccc(-c2ccc(Cl)cc2Cl)cc1)C1=C(O)c2ccccc2S(=O)(=O)N1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
43.00 | IC50 | CHEMBL1086883 | ChEMBL ↗ |
|
184487 ↗ |
Cc1ccc(-c2ccc(NC(=O)C3=C(O)c4ccccc4S(=O)(=O)N3)cc2)cc1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
2.24×103 | IC50 | CHEMBL1087143 | ChEMBL ↗ |
|
184488 ↗ |
O=C(Nc1ccccc1CCc1ccc(Cl)c(Cl)c1)C1=C(O)c2ccccc2S(=O)(=O)C1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
2.54×103 | IC50 | CHEMBL1087254 | ChEMBL ↗ |
|
184489 ↗ |
N#Cc1ccc(-c2ccc(NC(=O)C3=C(O)c4ccccc4S(=O)(=O)N3)cc2)cc1
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
3.96×103 | IC50 | CHEMBL1087266 | ChEMBL ↗ |
|
184490 ↗ |
COc1cc(/C=C/C(=O)CC(=O)/C=C/c2ccc(OCC=C(C)C)c(OC)c2)ccc1O
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
930.00 | IC50 | CHEMBL1087690 | ChEMBL ↗ |
|
184491 ↗ |
COc1cc(/C=C/C(=O)CC(=O)/C=C/c2ccc(OCC=C(C)C)c(OC)c2)ccc1OCC=C(C)C
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
2.00×103 | IC50 | CHEMBL1087807 | ChEMBL ↗ |
|
184492 ↗ |
CCCCC(Sc1nc(OCCc2ccc([N+](=O)[O-])cc2)cc(OCCc2ccc([N+](=O)[O-])cc2)n1)C(=O)O
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
3.70×103 | IC50 | CHEMBL1171652 | ChEMBL ↗ |
|
184493 ↗ |
CCCCC(Sc1nc(OCCc2ccc(C#N)cc2)cc(OCCc2ccc(C#N)cc2)n1)C(=O)O
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
5.90×103 | IC50 | CHEMBL1171831 | ChEMBL ↗ |
|
184494 ↗ |
CCCCC(Sc1nc(OCCc2ccsc2)cc(OCCc2ccsc2)n1)C(=O)O
|
CHEMBL5658 ↗
UniProt: O14684 ↗ |
6.50×103 | IC50 | CHEMBL1171832 | ChEMBL ↗ |