CHEMBL5763 IC50
BioactivityChEMBL CHEMBL5763 IC50 bioactivity data
3379 compounds · Target: Cholinesterase ( CHEMBL5763 ↗ ) · UniProt: P81908 ↗ · IC50
Cholinesterase, a molecular target studied in Equus caballus.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
11396 ↗ |
CCCCCCOC(=O)[C@H](CCC(=O)NCCC1CCN(Cc2ccccc2)CC1)NC(=O)Cc1cc2ccc(Cl)cc2s1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
50.00 | IC50 | CHEMBL1076243 | ChEMBL ↗ |
|
11397 ↗ |
CCCCCCOC(=O)[C@H](CCC(=O)NCCC1CCN(Cc2ccccc2)CC1)NC(=O)c1cc2ccccc2s1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
550.00 | IC50 | CHEMBL1076259 | ChEMBL ↗ |
|
11398 ↗ |
CCCCCCOC(=O)[C@H](CCC(=O)NCCC1CCN(Cc2ccccc2)CC1)NC(=O)c1cc2cccnc2s1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
950.00 | IC50 | CHEMBL1076260 | ChEMBL ↗ |
|
11399 ↗ |
CCCCCCOC(=O)[C@H](CCC(=O)NCCC1CCN(Cc2ccccc2)CC1)NC(=O)c1cc2ccsc2s1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
700.00 | IC50 | CHEMBL1080274 | ChEMBL ↗ |
|
11401 ↗ |
CCCCCCOC(=O)[C@H](CCC(=O)NCCC1CCN(Cc2ccccc2)CC1)NC(=O)c1ccccc1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
1.50×103 | IC50 | CHEMBL1080631 | ChEMBL ↗ |
|
11402 ↗ |
CCCCCCOC(=O)[C@H](CCC(=O)NCCC1CCN(Cc2ccccc2)CC1)NC(=O)c1cccs1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
1.00×103 | IC50 | CHEMBL1080813 | ChEMBL ↗ |
|
11403 ↗ |
CCCCCCOC(=O)[C@H](CCC(=O)NCCC1CCN(Cc2ccccc2)CC1)NC(=O)c1cc(Br)cs1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
750.00 | IC50 | CHEMBL1080814 | ChEMBL ↗ |
|
11406 ↗ |
CCCCCCOC(=O)[C@H](CCC(=O)NCCC1CCN(Cc2ccccc2)CC1)NC(=O)OC(C)(C)C
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
3.50×103 | IC50 | CHEMBL1082081 | ChEMBL ↗ |
|
11407 ↗ |
CCCCCCOC(=O)[C@H](CCC(=O)NCCC1CCN(Cc2ccccc2)CC1)NC(=O)OCc1ccccc1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
750.00 | IC50 | CHEMBL1082082 | ChEMBL ↗ |
|
11419 ↗ |
CCN(CC)C(C)CN1c2ccccc2Sc2ccccc21
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
720.00 | IC50 | CHEMBL1206 | ChEMBL ↗ |
|
11430 ↗ |
C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
7.37×103 | IC50 | CHEMBL1294 | ChEMBL ↗ |
|
11447 ↗ |
COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3[N+](=O)[O-])CC1)C2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
31.10×103 | IC50 | CHEMBL145361 | ChEMBL ↗ |
|
11452 ↗ |
C[C@@H]1CC[C@H]2[C@H](C)[C@H]3CC[C@@]4(O)[C@@H]5CC(=O)[C@H]6CC(=O)CC[C@]6(C)[C@H]5C[C@H]4[C@@H]3CN2C1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
3.68×103 | IC50 | CHEMBL1512936 | ChEMBL ↗ |
|
11459 ↗ |
COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3cccc(C)c3)CC1)C2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
5.83×103 | IC50 | CHEMBL170946 | ChEMBL ↗ |
|
11460 ↗ |
COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccc([N+](=O)[O-])cc3)CC1)C2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
12.20×103 | IC50 | CHEMBL171048 | ChEMBL ↗ |
|
11542 ↗ |
Nc1c2c(nc3oc(-c4ccccc4)cc13)CCCC2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
3.60×103 | IC50 | CHEMBL1916766 | ChEMBL ↗ |
|
11543 ↗ |
Nc1c2c(nc3c1cc(-c1ccccc1)n3-c1ccccc1)CCCC2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
74.00 | IC50 | CHEMBL1916768 | ChEMBL ↗ |
|
11544 ↗ |
Cc1ccc(-c2cc3c(N)c4c(nc3o2)CCCC4)cc1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
2.90×103 | IC50 | CHEMBL1916770 | ChEMBL ↗ |
|
11545 ↗ |
Nc1c2c(nc3oc(-c4ccc(Cl)cc4)cc13)CCCC2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
23.00×103 | IC50 | CHEMBL1916927 | ChEMBL ↗ |
|
11550 ↗ |
C#CCN(C)Cc1cc2cc(OCCCC3CCN(Cc4ccccc4)CC3)ccc2n1C
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
460.00 | IC50 | CHEMBL1929421 | ChEMBL ↗ |
|
11629 ↗ |
O[C@H]1CCN2Cc3ccccc3N=C12
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
2.53×103 | IC50 | CHEMBL2163791 | ChEMBL ↗ |
|
11630 ↗ |
CCC1=C[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@](C(=O)OC)(C2)[C@@H]13
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
5.17×103 | IC50 | CHEMBL2163793 | ChEMBL ↗ |
|
11796 ↗ |
CCOC(=O)c1c(C)nc2nc3c(c(N)c2c1-c1ccccc1)CCCC3
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
5.01×103 | IC50 | CHEMBL253386 | ChEMBL ↗ |
|
11816 ↗ |
COc1ccc(COc2nn(CCN(C(C)C)C(C)C)c3ccccc23)cc1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
2.28×103 | IC50 | CHEMBL3116280 | ChEMBL ↗ |
|
11818 ↗ |
c1ccc2c(COc3nn(CCN4CCCC4)c4ccccc34)cccc2c1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
6.70×103 | IC50 | CHEMBL3116283 | ChEMBL ↗ |
|
11819 ↗ |
c1ccc2c(COc3nn(CCN4CCCCC4)c4ccccc34)cccc2c1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
910.00 | IC50 | CHEMBL3116284 | ChEMBL ↗ |
|
11820 ↗ |
c1ccc2cc(COc3nn(CCN4CCCCC4)c4ccccc34)ccc2c1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
1.40×103 | IC50 | CHEMBL3116286 | ChEMBL ↗ |
|
11822 ↗ |
O=[N+]([O-])c1ccc2c(c1)c(OCc1ccc3ccccc3c1)nn2CCN1CCCCC1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
2.07×103 | IC50 | CHEMBL3116294 | ChEMBL ↗ |
|
11824 ↗ |
Nc1ccc2c(c1)c(OCc1ccc3ccccc3c1)nn2CCN1CCCCC1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
1.50×103 | IC50 | CHEMBL3116300 | ChEMBL ↗ |
|
11890 ↗ |
CCN(CC)CCCCCCOc1ccc(CC2NCCc3cc(OC)c(OC)cc32)cc1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
4.95×103 | IC50 | CHEMBL3262658 | ChEMBL ↗ |
|
11891 ↗ |
COc1cc2c(cc1OC)C(Cc1ccc(OCCCCCCN(C)C)cc1)NCC2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
8.65×103 | IC50 | CHEMBL3262661 | ChEMBL ↗ |
|
11892 ↗ |
CCCN(CCC)CCCCCCOc1ccc(CC2NCCc3cc(OC)c(OC)cc32)cc1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
4.32×103 | IC50 | CHEMBL3262662 | ChEMBL ↗ |
|
11893 ↗ |
CCCCN(CCCC)CCCCCCOc1ccc(CC2NCCc3cc(OC)c(OC)cc32)cc1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
3.46×103 | IC50 | CHEMBL3262663 | ChEMBL ↗ |
|
11894 ↗ |
COc1cc2c(cc1OC)C(Cc1ccc(OCCCCCCN3CCCC3C)cc1)NCC2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
3.35×103 | IC50 | CHEMBL3262664 | ChEMBL ↗ |
|
11895 ↗ |
COc1cc2c(cc1OC)C(Cc1ccc(OCCCCCCN3CCCCC3C)cc1)NCC2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
3.13×103 | IC50 | CHEMBL3262665 | ChEMBL ↗ |
|
11896 ↗ |
COc1cc2c(cc1OC)C(Cc1ccc(OCCCCCCN3CCCCC3)cc1)NCC2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
2.51×103 | IC50 | CHEMBL3262666 | ChEMBL ↗ |
|
11897 ↗ |
COc1cc2c(cc1OC)C(Cc1ccc(OCCCCCCN3CCCC3)cc1)NCC2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
2.34×103 | IC50 | CHEMBL3262667 | ChEMBL ↗ |
|
11898 ↗ |
COc1cc2c(cc1OC)C(Cc1ccc(OCCCCCCN3CCC(O)CC3)cc1)NCC2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
14.16×103 | IC50 | CHEMBL3262668 | ChEMBL ↗ |
|
11899 ↗ |
COc1cc2c(cc1OC)C(Cc1ccc(OCCCCCCN3CCOCC3)cc1)NCC2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
13.01×103 | IC50 | CHEMBL3262669 | ChEMBL ↗ |
|
11900 ↗ |
COc1cc2c(cc1OC)C(Cc1ccc(OCCCCCCN3CCC(O)(Cc4ccccc4)CC3)cc1)NCC2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
12.83×103 | IC50 | CHEMBL3262670 | ChEMBL ↗ |
|
11901 ↗ |
COc1cc2c(cc1OC)C(Cc1ccc(OCCCCCCN3CCN(c4ccccc4)CC3)cc1)NCC2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
8.78×103 | IC50 | CHEMBL3262671 | ChEMBL ↗ |
|
11902 ↗ |
COc1cc2c(cc1OC)C(Cc1ccc(OCCCCCCN3CCN(Cc4ccccc4)CC3)cc1)NCC2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
10.53×103 | IC50 | CHEMBL3262672 | ChEMBL ↗ |
|
11903 ↗ |
COc1cc2c(cc1OC)C(Cc1ccc(OCCCCCCN3CCC(c4ccccc4)CC3)cc1)NCC2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
7.99×103 | IC50 | CHEMBL3262673 | ChEMBL ↗ |
|
11904 ↗ |
CC[C@H]1CN2CCc3c([nH]c4ccccc34)[C@H]2C[C@@H]1/C(=C\OC)C(=O)OC
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
4.97×103 | IC50 | CHEMBL327134 | ChEMBL ↗ |
|
11921 ↗ |
C#CCN(Cc1ccc(O)c2ncccc12)C(C#N)CCC1CCN(Cc2ccccc2)CC1
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
1.60×103 | IC50 | CHEMBL3291019 | ChEMBL ↗ |
|
12036 ↗ |
Cc1c(C)c2c(c(C)c1O)CCC(C)(C(=O)NCCNc1c3c(nc4ccccc14)CCCC3)O2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
41.30 | IC50 | CHEMBL3410951 | ChEMBL ↗ |
|
12037 ↗ |
Cc1c(C)c2c(c(C)c1O)CCC(C)(C(=O)NCCCCCCCCCCNc1c3c(nc4ccccc14)CCCC3)O2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
262.80 | IC50 | CHEMBL3410957 | ChEMBL ↗ |
|
12038 ↗ |
Cc1c(Cl)c(=O)oc2cc(OCCN3CCN(CCCNc4c5c(nc6ccccc46)CCCC5)CC3)ccc12
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
72.56 | IC50 | CHEMBL3417299 | ChEMBL ↗ |
|
12039 ↗ |
Cc1c(C)c2ccc(OCCN3CCN(CCCNc4c5c(nc6ccccc46)CCCC5)CC3)cc2oc1=O
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
80.72 | IC50 | CHEMBL3417300 | ChEMBL ↗ |
|
12040 ↗ |
COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccc(C)cc3)CC1)C2
|
CHEMBL5763 ↗
UniProt: P81908 ↗ |
6.67×103 | IC50 | CHEMBL354848 | ChEMBL ↗ |