CHEMBL6136 IC50
BioactivityChEMBL CHEMBL6136 IC50 bioactivity data
1003 compounds · Target: Lysine-specific histone demethylase 1A ( CHEMBL6136 ↗ ) · UniProt: O60341 ↗ · IC50
Lysine-specific histone demethylase 1A, a molecular target studied in Homo sapiens.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
5831 ↗ |
C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
3.98×103 | IC50 | CHEMBL3353410 | ChEMBL ↗ |
|
9458 ↗ |
O=C(NO)c1ccc(CCCN2CCC(CN[C@H]3C[C@@H]3c3ccc(OCc4ccc(F)cc4)cc3)CC2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
4.00 | IC50 | CHEMBL4741826 | ChEMBL ↗ |
|
9459 ↗ |
COc1ccc([C@H]2C[C@@H]2NCC2CCN(CCCc3ccc(C(=O)NO)cc3)CC2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
6.00 | IC50 | CHEMBL4741936 | ChEMBL ↗ |
|
9466 ↗ |
O=C(NO)c1ccc(CCCN2CCc3cc(CN[C@H]4C[C@@H]4c4ccc(F)cc4)ccc3C2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
103.00 | IC50 | CHEMBL4744667 | ChEMBL ↗ |
|
9469 ↗ |
COc1ccc([C@H]2C[C@@H]2NCc2cn3c(n2)CN(CCCc2ccc(C(=O)NO)cc2)CC3)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
1.10×103 | IC50 | CHEMBL4745394 | ChEMBL ↗ |
|
9473 ↗ |
N#Cc1ccc(-c2ccc([C@H]3C[C@@H]3NCC3CCN(CCCc4ccc(C(=O)NO)cc4)CC3)cc2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
32.00 | IC50 | CHEMBL4746111 | ChEMBL ↗ |
|
9478 ↗ |
O=C(NO)c1ccc(CCCN2CCC(CN[C@H]3C[C@@H]3c3ccccc3)CC2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
5.50 | IC50 | CHEMBL4749146 | ChEMBL ↗ |
|
9488 ↗ |
O=C(NO)c1ccc(CCCN2CC(CN[C@H]3C[C@@H]3c3ccccc3)C2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
29.00 | IC50 | CHEMBL4750725 | ChEMBL ↗ |
|
9490 ↗ |
O=C(NO)c1ccc(CCN2CCC(CN[C@H]3C[C@@H]3c3ccccc3)CC2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
15.00 | IC50 | CHEMBL4750898 | ChEMBL ↗ |
|
9526 ↗ |
O=C(NO)c1ccc(CCCN2CCC(CN[C@@H]3C[C@H]3c3ccccc3)CC2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
4.00 | IC50 | CHEMBL4762346 | ChEMBL ↗ |
|
9530 ↗ |
CN(C)CCNC(=O)c1ccc([C@H]2C[C@@H]2NCC2CCN(CCCc3ccc(C(=O)NO)cc3)CC2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
22.00 | IC50 | CHEMBL4763662 | ChEMBL ↗ |
|
9535 ↗ |
O=C(NO)c1ccc(CCCN2CCC(CN[C@H]3C[C@@H]3c3ccc(C(=O)N4CCOCC4)cc3)CC2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
22.00 | IC50 | CHEMBL4777594 | ChEMBL ↗ |
|
9536 ↗ |
Cn1cc(-c2ccc([C@H]3C[C@@H]3NCC3CCN(CCCc4ccc(C(=O)NO)cc4)CC3)cc2)cn1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
43.00 | IC50 | CHEMBL4777609 | ChEMBL ↗ |
|
9544 ↗ |
Cc1noc(C)c1-c1ccc([C@H]2C[C@@H]2NCC2CCN(CCCc3ccc(C(=O)NO)cc3)CC2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
59.00 | IC50 | CHEMBL4780262 | ChEMBL ↗ |
|
9563 ↗ |
O=C(NO)c1ccc(CCCN2CCC(CN[C@H]3C[C@@H]3c3ccc(F)cc3)CC2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
6.00 | IC50 | CHEMBL4785144 | ChEMBL ↗ |
|
9578 ↗ |
O=C(NO)c1ccc(CCCN2CCC(CN[C@H]3C[C@@H]3c3ccc(-c4ccc(Cl)cc4)cc3)CC2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
2.00 | IC50 | CHEMBL4789904 | ChEMBL ↗ |
|
9579 ↗ |
O=C(NO)c1ccc(CCCN2CCC(CN[C@H]3C[C@@H]3c3ccc(-c4ccc(F)cc4)cc3)CC2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
821.00 | IC50 | CHEMBL4790127 | ChEMBL ↗ |
|
9586 ↗ |
O=C(NO)c1ccc(CCCN2CCC(CN[C@H]3C[C@@H]3c3ccc(C(=O)N4CCCCC4)cc3)CC2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
23.00 | IC50 | CHEMBL4791396 | ChEMBL ↗ |
|
9594 ↗ |
O=C(NO)c1ccc(CN2CCC(CN[C@H]3C[C@@H]3c3ccccc3)CC2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
11.00 | IC50 | CHEMBL4795265 | ChEMBL ↗ |
|
9599 ↗ |
O=C(NO)c1ccc(CCCN2CCC(CN[C@H]3C[C@@H]3c3ccc(-c4ccc(C(F)(F)F)nc4)cc3)CC2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
19.00 | IC50 | CHEMBL4796905 | ChEMBL ↗ |
|
9603 ↗ |
Cn1ccc(-c2ccc([C@H]3C[C@@H]3NCC3CCN(CCCc4ccc(C(=O)NO)cc4)CC3)cc2)cc1=O
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
21.00 | IC50 | CHEMBL4797928 | ChEMBL ↗ |
|
9607 ↗ |
O=C(NO)c1cnc(CCCN2CCC(CN[C@H]3C[C@@H]3c3ccccc3)CC2)s1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
22.00 | IC50 | CHEMBL4798455 | ChEMBL ↗ |
|
9866 ↗ |
O=C(NO)c1cccc(/C=C/c2ccnc(-c3ccccc3O)c2)c1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
2.26×103 | IC50 | CHEMBL5070176 | ChEMBL ↗ |
|
9875 ↗ |
O=C(NO)c1ccc(/C=C/c2ccnc(-c3ccccc3O)c2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
930.00 | IC50 | CHEMBL5075646 | ChEMBL ↗ |
|
9876 ↗ |
COc1ccc(-c2cc(/C=C/c3ccc(C(=O)NO)cc3)ccn2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
1.90×103 | IC50 | CHEMBL5075694 | ChEMBL ↗ |
|
9884 ↗ |
O=C(NO)c1ccc(/C=C/c2ccncc2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
850.00 | IC50 | CHEMBL5076948 | ChEMBL ↗ |
|
9904 ↗ |
COc1ccccc1-c1cc(/C=C/c2ccc(C(=O)NO)cc2)ccn1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
1.07×103 | IC50 | CHEMBL5081128 | ChEMBL ↗ |
|
9905 ↗ |
Cc1ccc(-c2cc(/C=C/c3ccc(C(=O)NO)cc3)ccn2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
2.70×103 | IC50 | CHEMBL5081200 | ChEMBL ↗ |
|
9906 ↗ |
O=C(NO)c1ccc(/C=C/c2ccnc(Br)c2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
1.02×103 | IC50 | CHEMBL5081459 | ChEMBL ↗ |
|
9908 ↗ |
O=C(NO)c1ccc(/C=C/c2ccnc(-c3cccc(O)c3)c2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
1.83×103 | IC50 | CHEMBL5081674 | ChEMBL ↗ |
|
9910 ↗ |
COc1ccc(F)cc1-c1cncc(/C=C/c2ccc(C(=O)NO)cc2)c1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
1.60×103 | IC50 | CHEMBL5081983 | ChEMBL ↗ |
|
9914 ↗ |
O=C(NO)c1ccc(/C=C/c2ccnc(-c3cccnc3)c2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
1.37×103 | IC50 | CHEMBL5083395 | ChEMBL ↗ |
|
9916 ↗ |
O=C(NO)c1cccc(/C=C/c2ccnc(-c3cc(F)ccc3O)c2)c1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
3.57×103 | IC50 | CHEMBL5084881 | ChEMBL ↗ |
|
9919 ↗ |
O=C(NO)c1ccc(/C=C/c2ccnc(-c3ccsc3)c2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
2.03×103 | IC50 | CHEMBL5085680 | ChEMBL ↗ |
|
9931 ↗ |
O=C(NO)c1ccc(/C=C/c2ccnc(-c3cccc(CO)c3)c2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
1.14×103 | IC50 | CHEMBL5087466 | ChEMBL ↗ |
|
9936 ↗ |
O=C(NO)c1ccc(/C=C/c2cccc(-c3ccccc3O)c2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
1.95×103 | IC50 | CHEMBL5087779 | ChEMBL ↗ |
|
9937 ↗ |
O=C(NO)c1ccc(/C=C/c2cccc(-c3cc(F)ccc3O)c2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
3.51×103 | IC50 | CHEMBL5087823 | ChEMBL ↗ |
|
9938 ↗ |
O=C(NO)c1ccc(/C=C/c2cncc(-c3ccccc3O)c2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
510.00 | IC50 | CHEMBL5087997 | ChEMBL ↗ |
|
9942 ↗ |
Cc1ccc(-c2cncc(/C=C/c3ccc(C(=O)NO)cc3)c2)c(F)c1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
3.06×103 | IC50 | CHEMBL5089538 | ChEMBL ↗ |
|
9954 ↗ |
O=C(NO)c1ccc(/C=C/c2cccc(-c3cccc(O)c3)c2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
3.65×103 | IC50 | CHEMBL5092482 | ChEMBL ↗ |
|
9962 ↗ |
Cc1ccc(-c2cc(/C=C/c3ccc(C(=O)NO)cc3)ccn2)c(F)c1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
1.64×103 | IC50 | CHEMBL5093633 | ChEMBL ↗ |
|
9967 ↗ |
O=C(NO)c1ccc(/C=C/c2ccnc(-c3cc(F)ccc3O)c2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
2.20×103 | IC50 | CHEMBL5094326 | ChEMBL ↗ |
|
13340 ↗ |
O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
1.26×103 | IC50 | CHEMBL50 | ChEMBL ↗ |
|
13930 ↗ |
Nc1ccccc1NC(=O)c1ccc(CNC2CC2c2ccccc2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
7.16×103 | IC50 | CHEMBL4162637 | ChEMBL ↗ |
|
13933 ↗ |
O=C(/C=C/c1ccc(CNC2CC2c2ccccc2)cc1)NO
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
2.21×103 | IC50 | CHEMBL4166084 | ChEMBL ↗ |
|
13940 ↗ |
O=C(NO)c1ccc(CNC2CC2c2ccccc2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
4.09×103 | IC50 | CHEMBL4169910 | ChEMBL ↗ |
|
13944 ↗ |
O=C(CCCCCCNC(=O)c1ccc(CNC2(c3ccccc3)CC2)cc1)NO
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
1.20×103 | IC50 | CHEMBL4173338 | ChEMBL ↗ |
|
13950 ↗ |
Nc1ccccc1NC(=O)/C=C/c1ccc(CNC2CC2c2ccccc2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
3.85×103 | IC50 | CHEMBL4176702 | ChEMBL ↗ |
|
13967 ↗ |
Cn1cc(-c2ccc(S(=O)(=O)n3ccc(/C=C/C(=O)Nc4ccccc4N)c3)cc2)cn1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
600.00 | IC50 | CHEMBL4283683 | ChEMBL ↗ |
|
14196 ↗ |
N[C@@H]1C[C@H]1c1ccc(OCC[C@H](NC(=O)c2ccccc2)C(=O)NCc2ccccc2)cc1
|
CHEMBL6136 ↗
UniProt: O60341 ↗ |
1.90×103 | IC50 | CHEMBL1215658 | ChEMBL ↗ |