CHEMBL6140 IC50
BioactivityChEMBL CHEMBL6140 IC50 bioactivity data
1032 compounds · Target: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A ( CHEMBL6140 ↗ ) · UniProt: Q9QYJ6 ↗ · IC50
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, a molecular target studied in Rattus norvegicus.
| ID ↑ | SMILES | Target | Activity (nM) | Type | Ref | Link | |
|---|---|---|---|---|---|---|---|
|
47752 ↗ |
COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
36.00 | IC50 | CHEMBL19224 | ChEMBL ↗ |
|
66032 ↗ |
Cc1cnc(COc2ccc(-c3nn(CCF)cc3-c3ccncc3)cc2)c(C)c1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
1.58 | IC50 | CHEMBL1915725 | ChEMBL ↗ |
|
66033 ↗ |
COc1ccc(COc2ccc(-c3nn(CCF)cc3-c3ccncc3)cc2)nc1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
3.16 | IC50 | CHEMBL1915726 | ChEMBL ↗ |
|
163010 ↗ |
COc1cc2nncc(-c3cnc(NC(C)C)c(C)c3)c2cc1OC
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
3.47 | IC50 | CHEMBL1956235 | ChEMBL ↗ |
|
163117 ↗ |
CCOC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4Cl)n3c2c1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
35.00 | IC50 | CHEMBL2311556 | ChEMBL ↗ |
|
163118 ↗ |
Cc1nc2ccc(CN3CCOCC3)cc2n2c(-c3ccccc3Cl)nnc12
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
35.00 | IC50 | CHEMBL2313234 | ChEMBL ↗ |
|
163119 ↗ |
Cc1nc2ccc(CN3CCN(C)CC3)cc2n2c(-c3ccccc3Cl)nnc12
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
74.00 | IC50 | CHEMBL2313236 | ChEMBL ↗ |
|
163120 ↗ |
Cc1nc2ccc(NC3CCOCC3)cc2n2c(-c3ccccc3Cl)nnc12
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
51.00 | IC50 | CHEMBL2313237 | ChEMBL ↗ |
|
163121 ↗ |
Cc1nc2ccc(N[C@H]3CC[C@H](O)CC3)cc2n2c(-c3ccccc3Cl)nnc12
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
52.00 | IC50 | CHEMBL2313238 | ChEMBL ↗ |
|
163122 ↗ |
Cc1nc2ccc(CN3CCC(O)CC3)cc2n2c(-c3ccccc3Cl)nnc12
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
39.00 | IC50 | CHEMBL2313240 | ChEMBL ↗ |
|
163123 ↗ |
CCNC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4Cl)n3c2c1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
74.00 | IC50 | CHEMBL2313247 | ChEMBL ↗ |
|
163124 ↗ |
CCNC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4OC)n3c2c1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
51.00 | IC50 | CHEMBL2313248 | ChEMBL ↗ |
|
163125 ↗ |
CCNC(=O)c1ccc2nc(C)c3nnc(-c4ccccc4F)n3c2c1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
52.00 | IC50 | CHEMBL2313249 | ChEMBL ↗ |
|
163126 ↗ |
CCNC(=O)c1ccc2nc(C)c3nnc(-c4ccccn4)n3c2c1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
39.00 | IC50 | CHEMBL2313251 | ChEMBL ↗ |
|
163127 ↗ |
CCNC(=O)c1ccc2nc(C)c3nnc(-c4cccnc4OC)n3c2c1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
35.00 | IC50 | CHEMBL2313256 | ChEMBL ↗ |
|
163128 ↗ |
Cc1nc2ccc(C(=O)NCc3ccccc3)cc2n2c(-c3ccccc3Cl)nnc12
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
74.00 | IC50 | CHEMBL2313258 | ChEMBL ↗ |
|
163129 ↗ |
Cc1nc2ccc(C(=O)N(C)Cc3ccccc3)cc2n2c(-c3ccccc3Cl)nnc12
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
51.00 | IC50 | CHEMBL2313259 | ChEMBL ↗ |
|
163130 ↗ |
Cc1nc2ccc(C(=O)NCCc3ccccc3)cc2n2c(-c3ccccc3Cl)nnc12
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
52.00 | IC50 | CHEMBL2313260 | ChEMBL ↗ |
|
163131 ↗ |
Cc1nc2ccc(C(=O)NCCN3CCCC3)cc2n2c(-c3ccccc3Cl)nnc12
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
39.00 | IC50 | CHEMBL2313262 | ChEMBL ↗ |
|
163192 ↗ |
c1ccc(Nc2ccc(Oc3nccnc3N3CCOCC3)cc2)nc1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
38.00 | IC50 | CHEMBL3086089 | ChEMBL ↗ |
|
163207 ↗ |
Cc1nc2ccncc2n2c(-c3ccccc3Cl)nnc12
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
480.00 | IC50 | CHEMBL3092559 | ChEMBL ↗ |
|
163310 ↗ |
Cn1cc(-c2cccc(Oc3nccc(-c4cn[nH]c4)n3)c2)c2nc3ccccc3cc21
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
122.40 | IC50 | CHEMBL3315031 | ChEMBL ↗ |
|
163313 ↗ |
Cn1cc(-c2cccc(Oc3nccc(-c4cncnc4)n3)c2)c2nc3ccccc3cc21
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
90.30 | IC50 | CHEMBL3315034 | ChEMBL ↗ |
|
163314 ↗ |
Cn1cc(-c2cccc(Oc3nccc(N4CCOCC4)n3)c2)c2nc3ccccc3cc21
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
166.90 | IC50 | CHEMBL3315035 | ChEMBL ↗ |
|
163315 ↗ |
Cn1cc(-c2cccc(Oc3nccnc3-c3cncnc3)c2)c2nc3ccccc3cc21
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
1.45×103 | IC50 | CHEMBL3315036 | ChEMBL ↗ |
|
163317 ↗ |
COc1ccc(-c2nccnc2Oc2ccc(-c3cn(C)c4cc5ccccc5nc34)cc2)cc1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
132.20 | IC50 | CHEMBL3315038 | ChEMBL ↗ |
|
163318 ↗ |
Cn1cc(-c2ccc(Oc3nccnc3-c3ccncc3)cc2)c2nc3ccccc3cc21
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
29.40 | IC50 | CHEMBL3315039 | ChEMBL ↗ |
|
163319 ↗ |
Cn1cc(-c2ccc(Oc3nccnc3-c3cncnc3)cc2)c2nc3ccccc3cc21
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
31.10 | IC50 | CHEMBL3315040 | ChEMBL ↗ |
|
163321 ↗ |
Cn1cc(-c2ccc(Oc3nccnc3-c3ccncc3)cc2)c2ncccc21
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
16.10 | IC50 | CHEMBL3315042 | ChEMBL ↗ |
|
163322 ↗ |
Cn1cc(-c2ccc(Oc3nccnc3-c3ccncc3)cc2)c2ncc(Cl)cc21
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
141.40 | IC50 | CHEMBL3315043 | ChEMBL ↗ |
|
163323 ↗ |
Cn1cc(-c2ccc(Oc3ncccc3-c3ccncc3)cc2)c2ncccc21
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
5.80 | IC50 | CHEMBL3315044 | ChEMBL ↗ |
|
163324 ↗ |
Cc1cnc2c(-c3ccc(Oc4ncccc4-c4ccncc4)cc3)cn(C)c2c1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
800.00×10-3 | IC50 | CHEMBL3315045 | ChEMBL ↗ |
|
163325 ↗ |
Cn1cc(-c2ccc(Oc3ncccc3-c3ccncc3)cc2)c2ncc(Cl)cc21
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
7.10 | IC50 | CHEMBL3315046 | ChEMBL ↗ |
|
163326 ↗ |
Cn1cc(C2=CCC(Oc3nccnc3-c3cncnc3)CC2)c2ncccc21
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
552.20 | IC50 | CHEMBL3315047 | ChEMBL ↗ |
|
163327 ↗ |
Cn1cc(C2CCC(Oc3nccnc3-c3cncnc3)CC2)c2ncccc21
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
371.70 | IC50 | CHEMBL3315048 | ChEMBL ↗ |
|
163343 ↗ |
c1ccc2nc(N3CC(Oc4nccnc4N4CCOCC4)C3)ccc2c1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
48.30 | IC50 | CHEMBL3352859 | ChEMBL ↗ |
|
163345 ↗ |
OCC1CCN(c2nccnc2OC2CN(c3cnc4ccccc4n3)C2)CC1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
37.80 | IC50 | CHEMBL3356307 | ChEMBL ↗ |
|
163346 ↗ |
OCC1CCN(c2nccnc2OC2CN(c3ncc4ccccc4n3)C2)CC1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
14.00 | IC50 | CHEMBL3356308 | ChEMBL ↗ |
|
163347 ↗ |
OCC1CCN(c2nccnc2O[C@@H]2CCN(c3ccc4ccccc4n3)C2)CC1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
167.00 | IC50 | CHEMBL3356647 | ChEMBL ↗ |
|
163348 ↗ |
OCC1CCN(c2nccnc2O[C@H]2CCN(c3ccc4ccccc4n3)C2)CC1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
78.00 | IC50 | CHEMBL3356648 | ChEMBL ↗ |
|
163350 ↗ |
OCCC1CCN(c2nccnc2OC2CN(c3ccc4ccccc4n3)C2)CC1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
12.40 | IC50 | CHEMBL3356653 | ChEMBL ↗ |
|
163351 ↗ |
OC1CCN(c2nccnc2OC2CN(c3ccc4ccccc4n3)C2)CC1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
26.10 | IC50 | CHEMBL3356654 | ChEMBL ↗ |
|
163352 ↗ |
OC1CN(c2nccnc2OC2CN(c3ccc4ccccc4n3)C2)C1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
94.70 | IC50 | CHEMBL3356655 | ChEMBL ↗ |
|
163353 ↗ |
OCC1CCN(c2nccnc2OC2CN(c3ccc4ccccc4n3)C2)C1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
43.40 | IC50 | CHEMBL3356656 | ChEMBL ↗ |
|
163354 ↗ |
COCC1CCN(c2nccnc2OC2CN(c3ccc4ccccc4n3)C2)CC1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
27.60 | IC50 | CHEMBL3356657 | ChEMBL ↗ |
|
163355 ↗ |
c1ccc2nc(N3CC(Oc4nccnc4N4CCCCC4)C3)ccc2c1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
39.70 | IC50 | CHEMBL3356658 | ChEMBL ↗ |
|
163356 ↗ |
CC1CCN(c2nccnc2OC2CN(c3ccc4ccccc4n3)C2)CC1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
124.00 | IC50 | CHEMBL3356659 | ChEMBL ↗ |
|
163357 ↗ |
CN(C)C1CCN(c2nccnc2OC2CN(c3ccc4ccccc4n3)C2)CC1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
520.00 | IC50 | CHEMBL3356660 | ChEMBL ↗ |
|
163359 ↗ |
NC(=O)C1CCN(c2nccnc2OC2CN(c3ccc4ccccc4n3)C2)CC1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
9.68 | IC50 | CHEMBL3356662 | ChEMBL ↗ |
|
163360 ↗ |
OCc1ccc(-c2nccnc2OC2CN(c3ccc4ccccc4n3)C2)cc1
|
CHEMBL6140 ↗
UniProt: Q9QYJ6 ↗ |
10.50 | IC50 | CHEMBL3356663 | ChEMBL ↗ |